Left Ventricular Function by Echocardiography, Tissue Doppler Imaging, and Carotid Intima-Media Thickness in Obese Adolescents With Nonalcoholic Fatty Liver Disease

Sert, Ahmet; Aypar, Ebru; Pirgon, Özgür; Yılmaz, Hakan; Odabaş, Dursun; Tolu, İsmet

doi:10.1016/j.amjcard.2013.03.056

Cited by 49 publications

(42 citation statements)

References 25 publications

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“…To date, a number of case-control studies have demonstrated that nondiabetic patients with NAFLD, both adults and children/adolescents, have echocardiographic features of early LVDD compared with their counterparts without NAFLD [9,[31][32][33][34][35][36][37]. These myocardial functional abnormalities appear to be independent of multiple cardio-metabolic risk factors.…”

Section: Discussionmentioning

confidence: 99%

Nonalcoholic fatty liver disease is independently associated with early left ventricular diastolic dysfunction in patients with type 2 diabetes

Mantovani

Pernigo

Bergamini

et al. 2015

Digestive and Liver Disease

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Section: Discussionmentioning

confidence: 99%

Nonalcoholic fatty liver disease is independently associated with early left ventricular diastolic dysfunction in patients with type 2 diabetes

Mantovani

Pernigo

Bergamini

et al. 2015

Digestive and Liver Disease

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“…While, the association between NAFLD and atherosclerosis could be easily explained by the abundance of circulating lipids present in obese children with NAFLD, it is more difficult to explain the relationship between NAFLD and cardiac function and geometry[14,15]. It has been reported that adolescents with NAFLD show an impaired systolic and diastolic function and an increased left ventricular mass compared to both healthy controls and age and gender matched obese adolescents without NAFLD[14,15] (Table 1).…”

Section: Cardiac Abnormalitiesmentioning

confidence: 99%

From the liver to the heart: Cardiac dysfunction in obese children with non-alcoholic fatty liver disease

Sessa¹,

Umano²,

Giudice³

et al. 2017

WJH

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In the last decades the prevalence of non-alcoholic fatty liver disease (NAFLD) has increased as a consequence of the childhood obesity world epidemic. The liver damage occurring in NAFLD ranges from simple steatosis to steatohepatitis, fibrosis and cirrhosis. Recent findings reported that fatty liver disease is related to early atherosclerosis and cardiac dysfunction even in the pediatric population. Moreover, some authors have shown an association between liver steatosis and cardiac abnormalities, including rise in left ventricular mass, systolic and diastolic dysfunction and epicardial adipose tissue thickness. In this editorial, we provide a brief overview of the current knowledge concerning the association between NAFLD and cardiac dysfunction.

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“…There are a few published articles on the influence of the NAFLD on LV diastolic dysfunction [18][19][20][21]. These studies demonstrated that diabetic and non-diabetic patients with NAFLD had early alterations in LV diastolic function as detected by tissue Doppler imaging [18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

“…These studies demonstrated that diabetic and non-diabetic patients with NAFLD had early alterations in LV diastolic function as detected by tissue Doppler imaging [18][19][20][21]. Fotbolcu et al [20] showed that normotensive and non-diabetic NAFLD patients have impaired LV diastolic dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…Bonapace et al [18] studied patients with Type 2 diabetes and NAFLD, and demonstrated early features of LV diastolic dysfunction in the presence of preserved systolic function. Recently published study found that obese adolescents with NAFLD had LV diastolic dysfunction detected by TDI (tissue Doppler imaging) [21]. In these studies, patients with NAFLD were enrolled according to US criteria.…”

Section: Discussionmentioning

confidence: 99%

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Left atrial deformation parameters in patients with non-alcoholic fatty liver disease: a 2D speckle tracking imaging study

et al. 2013

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The presence of the metabolic syndrome is a strong predictor for the presence of NASH (non-alcoholic steatohepatitis) in patients with NAFLD (non-alcoholic fatty liver disease). In the present study, we assessed LA (left atrial) deformation parameters in patients with NAFLD using 2D-STE (speckle tracking echocardiography) and to investigate if any changes exist between subgroups of the NAFLD. A total of 55 NAFLD patients and 21 healthy controls were included in the study. The diagnosis of NAFLD was based on liver biopsy. After patients were categorized into groups according to histopathological analysis (simple steatosis, borderline NASH, definitive NASH), all patients underwent echocardiography with Doppler examination. In the 2D-STE analysis of the left atrium, LA-Res (peak LA strain during ventricular systole), LA-Pump (peak LA strain during atrial systole), LA-SR(S) (peak LA strain rate during ventricular systole), LA-SR(E) (peak LA strain rate during early diastole) and LA-SR(A) (peak LA strain rate during atrial systole) were obtained. LA-Res, LA-Pump and LA-SR(A) were lower in the NAFLD group than in the control group. LA-Res was found to be significantly lower in NAFLD subgroups compared with healthy subjects (43.9±14.2 in healthy controls compared with 31.4±8.3 with simple steatosis, 32.8±12.8 with borderline NASH and 33.8±9.0 with definitive NASH). LA-Pump was significantly lower in the NAFLD group (18.2±3.1 in healthy controls compared with 13.3±4.7 with borderline NASH and 14.4±4.7 with definitive NASH). There were significant differences in LA-SR(A) between healthy controls compared with simple steatosis and borderline NASH (-1.56±0.36 compared with 1.14±0.38 and 1.24±0.32 respectively). Correlation analysis showed significant correlation of LA-Res values with E (early diastolic peak velocity)/E(m) (early diastolic mitral annular velocity) ratio (r=-0.50, P≤0.001), with LAVI (LA volume index; r=-0.45, P≤0.001) and with V(p) (propagation velocity; r=0.39, P≤0.001). 2D-STE-based LA deformation parameters are impaired in patients with NAFLD with normal systolic function. Although LA-Res and pump function parameters might be useful in estimating LV (left ventricular) filling pressure in the NAFLD patient group, it could not be used for differentiating the subgroups.

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Left Ventricular Function by Echocardiography, Tissue Doppler Imaging, and Carotid Intima-Media Thickness in Obese Adolescents With Nonalcoholic Fatty Liver Disease

Cited by 49 publications

References 25 publications

Nonalcoholic fatty liver disease is independently associated with early left ventricular diastolic dysfunction in patients with type 2 diabetes

Nonalcoholic fatty liver disease is independently associated with early left ventricular diastolic dysfunction in patients with type 2 diabetes

From the liver to the heart: Cardiac dysfunction in obese children with non-alcoholic fatty liver disease

Left atrial deformation parameters in patients with non-alcoholic fatty liver disease: a 2D speckle tracking imaging study

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