Legg-Calvé-Perthes disease

Abstract

Current knowledge of the causes and risk factors of Legg-Calvé-Perthesdisease (LCPD) does not allow effective preventive strategies. The outcome in adulthood is usually good. Hip osteoarthritis rarely develops before 50 years of age. The risk of osteoarthrosis depends chiefly on the final degree of joint incongruence. Age at onset and the lateral pillar classification are the two main outcome predictors and serve to guide the surgical indications based on the studies by Herring's group. Non-operative treatment is not effective. In contrast, femoral varus osteotomy and Salter's innominate osteotomy provide good outcomes. In severe forms, however, combining these two techniques or performing a triple pelvic osteotomy seem preferable. Surgery is now performed considerably less often than in the past, as it is effective only in patients with lateral pillar group B or B/C disease with onset after eight years of age. In other situations, therapeutic abstention is recommended.

The role and underlying mechanisms of microRNA‑214 in Legg‑Calv�‑Perthes disease

“…legg-calvé-Perthes disease (lcPd) is a pediatric form of femoral head osteonecrosis that mainly affects children between the ages of 2-12 years; lcPd is characterized by painful synovitis in the knees, avascular necrosis of the femoral head, and deformities of the femoral head and acetabulum (1)(2)(3). The disease typically leads to deformities, physical dysfunction and lifelong disability in children (4,5). at present, the main therapy for lcPd is surgical treatment; however, long-term (1.5-2 months) use of a brace is required to improve the state of the hip, resulting in a certain degree of limited hip joint activity (6,7).…”

Association of MTHFR and TNF-α genes polymorphisms with susceptibility to Legg-Calve-Perthes disease in Iranian children: A case-control study

“…2 Although the extensive literature pertaining to LCPD, there is still a gap in our knowledge about its risk factors, etiology and preventive strategies. 1,3,4 LCPD is a multifactorial disorder and apparently both genetic and environmental factors have been implicated in its etiopathogenic mechanisms. 2 However, a few familial cases with autosomal dominant inheritance due to mutations in a single gene such as COL2A1 have been reported.…”

The Imaging of Legg-Calve-Perthes Disease

“…(7) It is difficult to determine the risk groups for this disease; there are no pathognomonic clinical signs, so the patients often seek medical attention at the clinical stage with considerable bone destruction. (8) The onset of the disease usually occurs at the age of 4 to 12, with the highest incidence in 4-to 8-year-old children, though it may happen in adolescence. Boys suffer 3-5 times more often than girls.…”