Leiomyoma of the breast parenchyma: a case report and review of the literature

Abstract

INTRODUCTION: Benign tumors are often seen in breast screening examinations. However, the differential diagnosis is not always simple because of radiological similarity between the different benign lesions. CASE REPORT: We present a rare case report of leiomyoma of the breast parenchyma in a 68-year-old asymptomatic patient. The mammographic and ultrasonographic findings were similar to those observed in benign lesions. CONCLUSION: The histopathological diagnosis requires careful differentiation from lesions that have smooth muscle proliferation, especially leiomyosarcoma. The most commonly performed treatment is resection of the lesion with free margins. Although breast leiomyoma is rare, it should be considered among the differential diagnoses for breast nodules of benign appearance. Resection with safety margins proved to be the only treatment needed.

Chromosomal Translocation t(5;12)(p13;q14) Leading to Fusion of High-mobility Group AT-hook 2 Gene With Intergenic Sequences From Chromosome Sub-Band 5p13.2 in Benign Myoid Neoplasms of the Breast: A Second Case

“…Leiomyomas in the former location were first described by Virchow in 1854 and, since then, 50-60 cases have been reported (36,37). Leiomyomas of mammary parenchyma were first described by Strong in 1913, and approximately 30 cases have since been reported (31,32,35,39), one of them in a male patient (40). Whereas leiomyomas in the nippleareola complex are thought to arise from the dartoic muscles of the nipple (36,37), the histogenesis and origin of other breast leiomyomas remains unclear [see (31,39,41) and references therein].…”

“…Leiomyomas are common in some organs, primarily the uterus, but rare in the breast. They may be found either in the nipple-areola complex or in the mammary parenchyma (31)(32)(33)(34)(35)(36)(37)(38). Leiomyomas in the former location were first described by Virchow in 1854 and, since then, 50-60 cases have been reported (36,37).…”

A giant leiomyoma of the breast

“…The first description of parenchymal leiomyoma of the breast was made by Strong in 1913 [4]. Since then, no more than 33 cases have been published [2,3]. We report the 34 th case of breast leiomyoma, applying a series of macroscopic imaging to routine mammography and histological examination for the 1 st time.…”

“…Leiomyoma of the breast parenchyma in the absence of periareolar lesions is uncommon. To date, 33 cases of parenchymal leiomyoma of the breast have been reported [2,3]. As the initial diagnosis, a needle biopsy reveals a benign mesenchymal lesion, but the dilemma between leiomyoma and fibromatosis remains.…”

A case report of rare intraparenchymal leiomyoma of the breast – diagnostic and histopathological features

“…Leiomyomas usually appear as well-circumscribed lesions on mammography and ultrasonography. On mammography, the lesion is either isodense or hyperdense with no radial extensions, and no microcalcification (6,8). Sonographic criteria are nonspecific and include hypoechoic lesion with or without decreased posterior acoustic shadowing (9,10).…”