Lens thickness and insulin dependent diabetes mellitus: a population based twin study.

Løgstrup, Niels; Sjølie, Anne Katrin; Kyvik, Kirsten Ohm; Green, A

doi:10.1136/bjo.80.5.405

Cited by 19 publications

(13 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Duration of IDDM has earlier been shown to have a clear influence on lens thickness25-27 confirmed in our own twin study 28. Whether the increased lens thickness is responsible for the observed higher prevalence of low degree myopia among diabetics remains unclear, especially as the refractive index of the lens is altered at the same time.…”

supporting

confidence: 58%

Long term influence of insulin dependent diabetes mellitus on refraction and its components: a population based twin study

Løgstrup

Sjølie

Kyvik

et al. 1997

British Journal of Ophthalmology

View full text Add to dashboard Cite

Aim-To study whether refraction of the eye, or some of its components is influenced by duration of insulin dependent diabetes mellitus. Methods-From the young cohort of the population based Danish Twin Register, containing 20 888 twin pairs born between 1953 and 1982, all twin pairs having one or both partners aVected with IDDM were searched. Autorefraction, autokeratometry, and ultrasonic biometric measurements were carried out on 45 twin pairs: 16 monozygotic (MZ) twin pairs, 14 dizygotic twin pairs of same sex (DZss), and 15 dizygotic twin pairs of opposite sex (DZos). To obtain an estimate of the influence of duration of diabetes, the intrapair diVerences in duration of diabetes were correlated with intrapair diVerences in refraction and each of its components. Results-Refraction was statistically significantly negatively correlated with duration of diabetes in the DZss group, and axial length correspondingly positively correlated. Surprisingly, refraction and axial length in the MZ group, adjusted for confounding factors, were correlated with diabetes duration in the opposite direction than in the DZss group, although not reaching statistical significance. Lens thickness was statistically significantly positively correlated with duration of diabetes in both MZ and DZ twins. Anterior chamber depth was negatively correlated with duration of diabetes in all the zygosity groups. Conclusions-Studies of relations between refraction and duration of diabetes show diverging results. In the MZ group, a tendency to reduced axial length and corresponding hyperopia with increasing duration of diabetes was found. However, in the DZ group of same sex the opposite tendency was found. Increasing lens thickness and decreasing anterior chamber depth with increasing duration of diabetes have been confirmed in this study. (Br J Ophthalmol 1997;81:343-349) Refraction and its components are influenced by both environmental and inherited factors. Twin studies have earlier described the importance of genes in refraction, by high concordance rates of refraction in monozygotic twins compared with dizygotic twins.

show abstract

supporting

confidence: 58%

Long term influence of insulin dependent diabetes mellitus on refraction and its components: a population based twin study

Løgstrup

Sjølie

Kyvik

et al. 1997

British Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…Diabetics are known to have thicker lenses. [6][7][8]16 Therefore, to remove the confounding effect of diabetes on lens thickness, diabetics were excluded. Peripheral cortical spokes can be missed in the non-dilated pupil.…”

Section: Discussionmentioning

confidence: 99%

“…3 The thickness of the human lens has been found to be related to age, sex, cataract type, and diabetic status. [4][5][6][7][8][9] The primary objective of our observational study was to compare lens thickness measurements in eyes with a clear lens to eyes with different types of isolated cataract (nuclear, cortical, and posterior subcapsular (PSC)); the influence of age groups and axial length (AL) categories on lens thickness; and the impact of lens thickness on anterior chamber depth (ACD) in individuals with cataract and clear lens.…”

Section: Introductionmentioning

confidence: 99%

Lens thickness of Indian eyes: impact of isolated lens opacity, age, axial length, and influence on anterior chamber depth

Praveen

Vasavada

Shah

et al. 2008

Eye

View full text Add to dashboard Cite

Purpose To report relationship of age group and axial length (AL) category to lens thickness values in eyes with a clear lens or different types of isolated cataract (nuclear, cortical, and posterior subcapsular (PSC)). Further, we evaluated lens thickness values on anterior chamber depth (ACD) in these eyes. Design Observational clinic-based study. Methods An observational study of 1442 eyes of 1442 individuals (816 eyes with isolated cataract and 626 eyes with clear lens) of those above 25 years of age was evaluated. AL and lens thickness were performed with an A-scan ultrasound after dilatation of the pupil, and manual optical pachymetry was used to measure ACD after dilatation of the pupil. Main outcome measures: Lens thickness. Results Multiple regression analysis revealed that with each decade of advancement in age, the lens thickness increased by 0.155 mm (Po0.001). The difference in lens thickness after adjusting for age group and AL category was less in cortical cataract by À0.25 mm (Po0.001) and PSC by À0.29 mm (Po0.001); With advancement in AL category, lens thickness decreased by 0.004 mm (Po0.001). After adjusting for all the parameters/variables, regression analysis revealed that as lens thickness increased, there was a significant decrease in ACD (mean À0.44 mm; Po0.001). Conclusions Lens thickness was significantly greater in clear lenses when compared with isolated cataractsFgreatest with nuclear cataract and least with PSC. Age group and AL category had a significant impact on the lens thickness of both cataract and clear lens. A significant decrease in ACD was found with the increase in lens thickness.

show abstract

“…In patients with DM, the lens has been found thicker and more convex compared with healthy subjects. [54][55][56] Wiemer et al 57 observed an increase in the average lens thickness of 0.2 mm and a significant decrease in equivalent refractive index with age in both diabetic patients and control subjects, the greater decrease corresponded, however, to patients with type 1 DM. The fact that crystalline lens is thicker in people with DM might be due to not only an abnormality in the growth of the lens, greater cortical thickness, or osmotic swelling but also as a result of an increase in cell membrane permeability or deficiency in the ions pump.…”

Section: Crystalline Lensmentioning

confidence: 99%

“…72 There are factors that may contribute to the change in aberrations, such as ageing, [73][74][75][76][77] accommodation, 78 photoreceptors, 73 pupil size, 71,[79][80][81][82] refractive surgery, 76,[83][84][85] and tear film. 86,87 Even though there are no studies evaluating the impact that these factors could have on HOAs in people with DM, these do have a thicker and more convex lens, [54][55][56] can develop premature cataracts, [9][10][11] and suffer a series of changes associated with lachrymal gland dysfunction and dry eye syndrome. [16][17][18][19][20][21][22][23][24][25][26] Patients with DM who undergo laser-assisted in situ keratomileusis are also at a significantly higher risk of developing postoperative epithelial complications, and refractive results tend to be worse compared with healthy people.…”

Section: Aberrationsmentioning

confidence: 99%

Optical quality of the diabetic eye: a review

Calvo-Maroto

Pérez-Cambrodí²,

Albarán-Diego

et al. 2014

Eye

View full text Add to dashboard Cite

Diabetes mellitus is a metabolic disorder characterized by the presence of chronic hyperglycaemia. Several structural, morphological, and physiological changes in each of ocular component have been described in detail during the past decades. Due to these abnormalities, the diabetic patient undergoes a degradation of the retinal image by an increase of higher ocular aberrations and ocular scattering coming from mainly tear film, cornea, and crystalline lens. This review aims to provide an overview of current knowledge about the effects of diabetes mellitus in these optical phenomena and its consequence on the visual quality of the diabetic patient.

show abstract

Lens thickness and insulin dependent diabetes mellitus: a population based twin study.

Abstract: (BrJ Ophthalmol 1996; 80: 405-408)

Cited by 19 publications

References 20 publications

Long term influence of insulin dependent diabetes mellitus on refraction and its components: a population based twin study

Long term influence of insulin dependent diabetes mellitus on refraction and its components: a population based twin study

Lens thickness of Indian eyes: impact of isolated lens opacity, age, axial length, and influence on anterior chamber depth

Optical quality of the diabetic eye: a review

Contact Info

Product

Resources

About