Leptin and its potential interest in assisted reproduction cycles

Catteau, A.; Caillon, Hélène; Barrière, P.; Denis, Manon; Masson, David; Fréour, Thomas

doi:10.1093/humupd/dmv057

Cited by 61 publications

(41 citation statements)

References 138 publications

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“…The potential pharmacological use of leptin to improve or reduce the impact on obese male fertility has been already suggested and although their potential use in clinical practice is promising, the data are still limited and need further confirmation (Alves et al ., ). Interestingly, previous studies suggested also the potential clinical use of leptin as a biomarker in IVF cycles, considering that high serum and/or follicular fluid leptin concentrations have correlated negatively with cycle outcome (Catteau et al ., ).…”

Section: Discussionmentioning

confidence: 97%

Genetic variation in leptin and leptin receptor genes as a risk factor for idiopathic male infertility

et al. 2016

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SUMMARYThe aim of this study was to examine whether there is an association among genetic variability in leptin (LEP) and leptin receptor (LEPR) genes and male infertility. We performed a case-control study and were searching for an association between polymorphisms of LEP and LEPR genes and male infertility. The study group consisted of 317 patients with idiopathic infertility and a control group of 241 fertile men from Slovenia. Four single nucleotide polymorphisms (SNPs) in LEP gene and four single nucleotide polymorphisms (SNPs) in LEPR gene were chosen and genotyped. Statistically significant SNP was further validated in additional 255 infertile patients and 168 controls from Serbia and Macedonia. In the Slovenian population, we found a statistically significant difference in genotype distribution for rs10244329 polymorphism in LEP gene (recessive genotype model, p value = 0.048). The trend toward statistically significant difference in genotype distribution for rs10244329 polymorphism was confirmed in the Serbian and Macedonian populations (p value = 0.07). Our data suggest that genetic variability in the LEP gene might be associated with male infertility warranting further confirmation and mechanistic investigations.

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Section: Discussionmentioning

confidence: 97%

Genetic variation in leptin and leptin receptor genes as a risk factor for idiopathic male infertility

et al. 2016

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“…OB‐R belongs to class I cytokine superfamily, and there are at least six different isoforms, named OB‐R a , OB‐R b , OB‐R c , OB‐R d , OB‐R e , OB‐R f . The six isoforms are divided into three categories: short (OB‐R a , OB‐R c , OB‐R d , OB‐R f ), long (OB‐R b ) and soluble (OB‐R e ) forms (Catteau et al., ; Wauman, Zabeau, & Tavernier, ). (Figure ) Different OB‐R activation conveys different biological activities of leptin.…”

Section: Structure and Expression Of Leptin And Leptin Receptormentioning

confidence: 99%

Review of the role of leptin in the regulation of male reproductive function

Zhang

Gong

2018

Andrologia

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Since discovered in 1994, leptin has been thought to be a pleiotropic hormone that regulates food intake, controls energy balance in the body and influences multiple tissues in the body. Leptin plays an important mediating role in the regulation of neuroendocrine and can transmit the nutritional status signals to the reproductive-related central nervous system. Many studies have shown that leptin may play an important role in the control of reproductive function. Leptin can act on all levels of the hypothalamus-pituitary-gonadal (HPG) axis and may have local effects on the function of testis and spermatogenesis. Leptin is critical for puberty initiation and can also modulate testosterone synthesis by downregulating cAMP-dependent activation of steroidogenic genes expressions. Leptin is found to be higher in infertile men than in normal subjects. Yet, the exact role of leptin in the regulation of male reproductive function remains incomplete. The purpose of this review was to summarise the recent research about the biological effects of leptin on male reproductive system. In-depth study of leptin in reproductive system will help to reveal the pathogenesis of infertility and provide new treatment ideas for human assisted reproductive technology.

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“…Leptin is an adipocyte hormone and is also called as the master hormone of the body which is produced mostly by adipocytes and by granulosa, theca cells and cumulus cells of ovarian follicles (Kamyabi and Gholamalizade, 2015;Catteau et al, 2016). It is a 16-kDa protein of 167 amino acids plays a crucial role in the regulation of energy balance and body weight control (Farhood et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…Circulating leptin binds to leptin receptor and functions as part of a signalling pathway, including Janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3), insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase (PI3K), mitogen-activated protein kinase (MAPK), and 5' adenosine monophosphate-activated protein kinase (AMPK)/ acetyl-CoA carboxylase (ACC). Among these, the JAS/STAT3 plays an important role in the regulation of energy homeostasis (Catteau et al, 2016). In human beings, leptin and leptin receptor genes are present at chromosomal locations 7q32.1 and 1p31.3 respectively.…”

Section: Introductionmentioning

confidence: 99%

Insights into the putative role of leptin in various traversing stages of women: A narrative review

2018

J App Pharm Sci

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From adolescence to adulthood, a woman goes through distinct phases in her life. The role of leptin in this journey is very crucial, as it supports her to cross different milestones in time. Leptin is an indispensable factor in the metabolic control of puberty, fertility, and pregnancy. Puberty is a chronic biological process that helps transform a child into an adult. In this process, sufficient amount of leptin is necessary for the initiation of puberty in girls. Apart from maintaining the energy homeostasis by regulating the food intake and energy expenditure, it also regulates various other hormones required for reproduction and regulation of the endocrine system. Malfunction of leptin alters the neuroendocrine pathways and causes a detrimental effect on reproductive disorders, such as PCOS, obesity, diabetes, anorexia, and infertility which are the most important intimation for female reproductive health worldwide. In this article, we aim to provide a synoptic view on the roles of leptin in the metabolic regulation of the reproductive axis, its hormonal regulations, permissive role for the onset of puberty, continuity of menstrual cycle and the putative roles of leptin during gestation, including its potential function as placental hormone in a female.

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Leptin and its potential interest in assisted reproduction cycles

Cited by 61 publications

References 138 publications

Genetic variation in leptin and leptin receptor genes as a risk factor for idiopathic male infertility

Genetic variation in leptin and leptin receptor genes as a risk factor for idiopathic male infertility

Review of the role of leptin in the regulation of male reproductive function

Insights into the putative role of leptin in various traversing stages of women: A narrative review

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