Leptin-induced increase in blood pressure and markers of endothelial activation during pregnancy in Sprague Dawley rats is prevented by resibufogenin, a marinobufagenin antagonist

Hassan, M; Bakar, Nor Salmah; Aziz, Mardiana Abdul; Basah, Norizan Kamal; Singh, Harbindar Jeet Singh Gurcharan

doi:10.1016/j.repbio.2020.03.004

Cited by 9 publications

(6 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…33 Furthermore, leptin is also shown to activate sympathetic nervous system. 35 Leptin injection significantly increased systolic blood pressure (SBP) in Sprague-Dawley rats 36 but had no effect in humans. 37 Furthermore, leptin is reported to have a positive correlation with kisspeptin in human subjects.…”

Section: Introductionmentioning

confidence: 99%

Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects

Chatree

Sitticharoon

Maikaew

et al. 2020

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

Obesity is one of major risk factors increasing chronic diseases including type II diabetes, cardiovascular diseases, and hypertension. The effects of epigallocatechin gallate (EGCG), the major active compound in green tea, on reduced obesity and improved metabolic profiles are still controversial. Furthermore, the effects of EGCG on human adipocyte lipolysis and browning of white adipocytes have not been elucidated. This study aimed to investigate the effects of EGCG on obesity, lipolysis, and browning of human white adipocytes. The results showed that, when compared to the baseline values, EGCG significantly decreased fasting plasma triglyceride levels ( P < 0.05), systolic blood pressure ( P < 0.05), diastolic blood pressure ( P < 0.05), and serum kisspeptin levels ( P < 0.05) after 8 weeks of supplement. On the other hand, supplement of EGCG in obese human subjects for 4 or 8 weeks did not decrease body weight, body mass index, waist and hip circumferences, nor total body fat mass or percentage when compared to their baseline values. The study in human adipocytes showed that EGCG did not increase the glycerol release when compared to vehicle, suggesting that it had no lipolytic effect. Furthermore, treatment of EGCG did not enhance uncoupling protein 1 ( UCP1) mRNA expression in human white adipocytes when compared with treatment of pioglitazone, the peroxisome proliferator-activated receptor γ (PPAR-γ) agonist, suggesting that EGCG did not augment the browning effect of PPAR-γ on white adipocytes. This study revealed that EGCG reduced 2 metabolic risk factors which are triglyceride and blood pressure in the human experiment. We also showed a novel evidence that EGCG decreased kisspeptin levels. However, EGCG had no effects on obesity reduction in humans, lipolysis, nor browning of human white adipocytes. Impact statement Obesity has become the worldwide problem that causes adverse health consequences in individuals. The effects of EGCG on decreased obesity and improved metabolic profiles are still inconclusive. This study revealed that EGCG decreased 2 metabolic risk factors including blood pressure and triglyceride in human obese subjects but had no effect on obesity reduction. This study also showed a novel finding that EGCG decreased kisspeptin levels in human obese subjects. The study in human adipocytes showed that EGCG had no effects on lipolysis nor browning of human white adipocytes. These findings might suggest that EGCG treatment ameliorated metabolic parameters but did not reduce obesity in obese humans. However, further studies are required to explore the relationship between the effect of EGCG on reduction of blood pressure and kisspeptin levels.

show abstract

Section: Introductionmentioning

confidence: 99%

Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects

Chatree

Sitticharoon

Maikaew

et al. 2020

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

show abstract

“…VcAM-1 is an important adhesion molecule associated with Ec activation (21,22). The induced expression of VcAM-1 has been reported to increase the adhesion of leukocytes expressing the counter receptor, integrin α4β1 (23,24).…”

Section: Ho-1 Knockdown Upregulates the Expression Of Vcam-1 To Induce Neutrophil Recruitment During Renal Ischemia-reperfusion Injurymentioning

confidence: 99%

HO‑1 knockdown upregulates the expression of VCAM‑1 to induce neutrophil recruitment during renal ischemia‑reperfusion injury

Yao

et al. 2021

Int J Mol Med

View full text Add to dashboard Cite

“…З іншого боку, збільшення експресії лептину під час вагітності, ускладненій ГГ та переклампсією, може бути результатом інших подразників. Показано, що материнська гіперлептинемія посилює гіпертензію через здатність лептину активувати симпатичну нервову систему та стимулювати секрецію катехоламінів [14]. У нашій роботі продемонстровано позитивний кореляційний зв'язок між концентрацією лептину, ГЗМТ та відсотком ЖМТ у вагітних з ГГ та прееклампсією вже в другому триместрі.…”

Section: проблеми ендокринної патології № 3 2021unclassified

“…Гестаційна гіпертензія (ГГ) виникла у 29 (15,3 %), прееклампсія у 39 (20,5 %) випадків, а 122 (64,2 %) осіб були нормотензивні. Рекомендоване ГЗМТ (11,(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16),0 кг) виявлено у 133 (70,0 %), надлишкове у 57 (30,0 %) пацієнток. У вагітних з надлишковим ГЗМТ частота виникнення ГГ у 2,2 раза (р < 0,05) та прееклампсії у 4,2 раза (р < 0,001) більша порівняно з пацієнтками з рекомендованим ГЗМТ.…”

unclassified

The Role of Hyperleptinemia in the Genesis of Gestational Hypertension and Preeclampsia

Ostafiichuk

Drohomyretska

Motsyuk

et al. 2021

PEP

View full text Add to dashboard Cite

The aim of the study was to determine the association of serum leptin levels in pregnant women with the risk of hypertensive disorders depending on gestational weight gain (GWG). We have studied 190 pregnant women with a normal pre-pregnancy body mass index, who were registered at the City Clinical Perinatal Center, Ivano-Frankivsk, Ukraine. Quantitative determination of leptin in serum was performed by ELISA Kit (CAN-L-4260, Canada). Statistical analyses based on Microsoft Excel statistical analysis package and Statistica 6.0. Gestational hypertension (GH) has developed in 29 (15.3 %), preeclampsia in 39 (20.5 %) cases and 122 (64.2%) pregnant were normotensive. The recommended GWG (11.5-16.0 kg) was diagnosed in 133 (70.0 %), excessive in 57 (30.0 %) patients. The frequency of GH was 2.2-fold (p<0.05) and preeclampsia was 4.2-fold (p<0.001) higher in pregnant with excessive GWG, compared to patients with the recommended GWG. Leptin concentrations in pregnant with GH were 1.5-fold in the third trimester (p<0.01), and with preeclampsia 1.1-fold in the second (p<0.01) and 1.5-fold in the third (p<0.01) trimesters higher compared to normotensive women. Serum leptin concentrations of pregnant with GH and preeclampsia were significantly higher in the group with excessive GWG compared to the recommended, which were detected in the second trimester. A high degree of risk of hyperleptinemia in the groups of pregnant with GH (OR=3.50; 95%CI: 1.48-9.33; p<0.05), and with preeclampsia (6.01; 2.43-15.02) was found in women with excessive GWG. A positive correlation was found between leptin concentration, GWG and body fat percentage in pregnant with GH and preeclampsia in the second and third trimesters. Thus, leptin can be considered a marker of the association between pathological GWG and hypertensive disorders in pregnancy

show abstract

Leptin-induced increase in blood pressure and markers of endothelial activation during pregnancy in Sprague Dawley rats is prevented by resibufogenin, a marinobufagenin antagonist

Cited by 9 publications

References 57 publications

Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects

Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects

HO‑1 knockdown upregulates the expression of VCAM‑1 to induce neutrophil recruitment during renal ischemia‑reperfusion injury

The Role of Hyperleptinemia in the Genesis of Gestational Hypertension and Preeclampsia

Contact Info

Product

Resources

About