Leptin-induced matrix metalloproteinase-2 secretion is suppressed by trans-10,cis-12 conjugated linoleic acid

Moon, Hee Sun; Lee, Hong Gu; Seo, Ji‐Hyun; Chung, Chung Soo; Guo, Dandan; Kim, Tae Gyu; Choi, Yun Jaie; Cho, Chong Su

doi:10.1016/j.bbrc.2007.03.068

Cited by 23 publications

(16 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…MMP2 is produced by synovial fibroblasts (79,81,82), by macrophages, particularly after stimulation with LPS (83), and by endothelial cells (84,85), particularly after stimulation with TGF-ß1 (86) or LPS (87). MMP2 is also produced by adipocytes (88). In our experiment, all agents tested, that is LPS, TNF, IL-4 and TGF-ß1, decreased the expression of MMP2 mRNA ( Fig.…”

Section: Discussionsupporting

confidence: 57%

Influence of LPS, TNF, TGF-ï¿½1 and IL-4 on the expression of MMPs, TIMPs and selected cytokines in rat synovial membranes incubated in vitro

Hyc

Osiecka-Iwan²,

Niderla-Bielińska

et al. 2010

Int J Mol Med

View full text Add to dashboard Cite

Abstract. Synovial membranes are formed by four main types of cells, i.e. fibroblasts, macrophages, epitheliocytes and adipocytes. To study the combined effect of various factors on these cell populations, synovial membranes dissected from rat knee joints were incubated in control medium or medium with lipopolysaccharide (LPS), TNF, TGF-ß1 or IL-4 for 12 h. LPS stimulated TNF secretion and both agents stimulated secretion of IL-6. TGF-ß1 slightly increased IL-6 secretion. LPS increased the mRNA levels of IL-6, IL-1ß, TGF-ß1, MMP1a, MMP1b, MMP3, MMP9, MMP13, MMP14, TIMP1 and TIMP3 while the mRNA levels of MMP2, TIMP2 and TIMP4 were significantly decreased. Expression of IL-1ß, MMP1a, MMP1b, MMP3, MMP9, MMP13 and TIMP1 increased after TNF treatment, while mRNA levels of MMP2, MMP14, TIMP2, TIMP3 and TIMP4 were decreased. TGF-ß1 decreased the mRNA levels of IL-1ß, all MMPs, TIMP1, TIMP2, TIMP4 and increased mRNA levels of itself and TIMP3. IL-4 decreased mRNA levels of IL-1ß, TGF-ß1, MMP2, MMP9, MMP13 and all TIMPs. Only LPS decreased the amount and activity of MMP2. The effect of LPS and cytokines on most of the MMPs and TIMPs produced by whole synovial membrane was in good agreement with previous studies on their action on similar types of cells as those present in synovial membranes, but originating from other tissues. All tested agents decreased MMP2 mRNA expression levels and in the case of LPS also the protein level and its activity determined by zymography, contrary to previous observations on isolated cell populations. This indicates that the response of the organized tissue is an interplay of all components and cannot be deduced from the individual reactions.

show abstract

Section: Discussionsupporting

confidence: 57%

Influence of LPS, TNF, TGF-ï¿½1 and IL-4 on the expression of MMPs, TIMPs and selected cytokines in rat synovial membranes incubated in vitro

Hyc

Osiecka-Iwan²,

Niderla-Bielińska

et al. 2010

Int J Mol Med

View full text Add to dashboard Cite

show abstract

“…Tolylsam treatment was associated with significantly reduced levels of leptin, which correlate positively with body fat mass and adipocyte size [5,18]. Leptin contributes to enhanced MMP-2 levels in different cell types [7][8][9][10][11][12]. In vascular smooth muscle cells leptin induces MMP-2 expression via protein kinase C-dependent activation of NAD(P)H oxidase with subsequent activation of the ERK1/2/NF-kappa B pathways [8].…”

Section: Metabolic Parametersmentioning

confidence: 99%

“…It is well known that leptin, the product of the ob gene, is an endocrine hormone that regulates adipose tissue mass. In addition several in vitro and in vivo studies have revealed that leptin induces MMP-2 expression and activity [7][8][9][10][11][12]. This raises the question whether the marked effect of gelatinase inhibition by Tolylsam in a murine model of nutritionally induced obesity may be due not only to direct MMP inhibition, but also to an indirect effect via reduction of leptin and associated decrease in MMP-2 levels.…”

mentioning

confidence: 99%

Matrix metalloproteinase inhibition impairs murine adipose tissue development independently of leptin

Hul

Lijnen

2011

Endocr J

View full text Add to dashboard Cite

“…Of these proteins, adiponectin, which is exclusively secreted from adipose tissue, has insulin-sensitizing properties that enhance fatty acid oxidation, liver insulin action, and glucose uptake and positively affect serum triglyceride levels (12)(13)(14)(15). Adiponectin exists as both low-molecular weight (LMW) oligomers and high-molecular weight (HMW) multimers (15)(16)(17). HMW adiponectin is reported to be more active and correlates with glucose and insulin levels when compared with both LMW and total adiponectin (16,18,19).…”

mentioning

confidence: 99%

L-4F treatment reduces adiposity, increases adiponectin levels, and improves insulin sensitivity in obese mice

Peterson

Drummond

Kim

et al. 2008

Journal of Lipid Research

149

167

View full text Add to dashboard Cite

We hypothesized that the apolipoprotein mimetic peptide L-4F, which induces arterial anti-oxidative enzymes and is vasoprotective in a rat model of diabetes, would ameliorate insulin resistance and diabetes in obese mice. L-4F (2 mg/kg/d) administered to ob/ob mice for 6 weeks limited weight gain without altering food intake, decreased visceral (P , 0.02) and subcutaneous (P , 0.045) fat content, decreased plasma IL-1b and IL-6 levels (P , 0.05) and increased insulin sensitivity, resulting in decreased glucose (P , 0.001) and insulin (P , 0.036) levels. In addition, L-4F treatment increased aortic and bone marrow heme oxygenase (HO) activity and decreased aortic and bone marrow superoxide production (P , 0.001). L-4F treatment increased serum adiponectin levels (P , 0.037) and decreased adipogenesis in mouse bone marrow (P , 0.039) and in cultures of human bone marrow-derived mesenchymal stem cells (P , 0.022). This was manifested by reduced adiposity, improved insulin sensitivity, improved glucose tolerance, increased plasma adiponectin levels, and reduced IL-1b and IL-6 levels in obese mice. This study highlights the existence of a temporal relationship between HO-1 and adiponectin that is positively affected by L-4F in the ob/ob mouse model of diabetes, resulting in the amelioration of the deleterious effects of diabetes.-Peterson,

show abstract

Leptin-induced matrix metalloproteinase-2 secretion is suppressed by trans-10,cis-12 conjugated linoleic acid

Cited by 23 publications

References 39 publications

Influence of LPS, TNF, TGF-ï¿½1 and IL-4 on the expression of MMPs, TIMPs and selected cytokines in rat synovial membranes incubated in vitro

Influence of LPS, TNF, TGF-ï¿½1 and IL-4 on the expression of MMPs, TIMPs and selected cytokines in rat synovial membranes incubated in vitro

Matrix metalloproteinase inhibition impairs murine adipose tissue development independently of leptin

L-4F treatment reduces adiposity, increases adiponectin levels, and improves insulin sensitivity in obese mice

Contact Info

Product

Resources

About