Lessons Learned From the First Quadruple Extremity Transplantation in the World

Nasır, Serdar; Kilic, Yakup; Karaaltın, Mehmet Veli; Erdem, Yunus

doi:10.1097/sap.0000000000000279

Cited by 32 publications

(26 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…All transplanted patients reached protective sensation, 91% of them tactile sensation and 82% a certain degree of discriminative sensation. Patients regained independence in daily activities, such as dressing, shaving, driving, riding motorcycles, writing and some of them returned to work [5][6][7][8][9][10][11][12][13][14][15][16].…”

Section: Hand and Upper Extremity Transplantationmentioning

confidence: 99%

Vascularized composite allotransplantation - a Council of Europe position paper

et al. 2018

View full text Add to dashboard Cite

Summary After more than 120 hand‐upper extremity and 37 face transplant procedures performed worldwide, vascularized composite allotransplantation (VCA) now falls under the scope of organ transplant legislation in Europe and the United States. While in the USA, VCA has been considered as standard care since 2014, VCA in Europe is still performed through clinical research trials, except in United Kingdom. However, after two decades of favourable experience with upper extremity transplantation (UET), professionals in Europe are proposing hand allotransplantation as “controlled standard” care, as opposed to face transplantation (FT), which is still a challenging activity. The European Committee on Organ Transplantation (CD‐P‐TO) has elaborated a position paper to provide recommendations concerning regulatory aspects for UET and FT. It is aimed at Health Authorities in charge of the oversight – and coordination – of organ donation and transplantation, and at professional groups to help them manage such complex and costly programs dedicated to properly selected patients.

show abstract

Section: Hand and Upper Extremity Transplantationmentioning

confidence: 99%

Vascularized composite allotransplantation - a Council of Europe position paper

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Erdem et al first attempted quadruple extremity transplantation on a 27 year old man who lost his limbs due to electrocution. The patient developed cardiac arrest intra-operatively due to metabolic derangement [5]. He died on post-operative day five.…”

Section: Discussionmentioning

confidence: 99%

“…In the second case described by Cavadas et al even though the patient was able to mobilise with partial weight bearing, the limb had to be amputated because the patient developed a complication due to long term immuno-suppression (lymphoma) [3]. In the fourth case described by Erdem et al it appears that due to practical problems of performing all 4 limb transplants together, it was difficult to maintain the metabolic balance of the patient during surgery which resulted in his death [5].…”

Section: Discussionmentioning

confidence: 99%

Trans-femoral lower limb transplantation in a Sri Lankan patient: a case report and surgical technique

Arudchelvam¹,

Ratnayake²,

Wijesinghe³

et al. 2018

Ceylon Med. J.

View full text Add to dashboard Cite

“…În anul 2012, au mai fost efectuate în Turcia transplanturi de membre pelvine asociate cu alotransplant bilateral de membre superioare la doi pacienţi, la ambii apărând complicaţii ce au dus la deces [63,64]. După cum s-a observat în urma eşecurilor acestor proceduri, sunt o serie de aspecte ce constituie limitări în utilizarea pe scară largă a acestora: recuperarea funcţională variabilă, dependentă de sediul şi mecanismul amputaţiei, fiind şanse ca regenerarea nervoasă aşteptată în transplanturile proximale să nu fie satisfăcătoare; problemele hemodinamice generate de transplantarea unei mase mari de ţesut, determinând redistribuţia volumului sangvin, impunându-se un suport important de reanimare, complicaţiile terapiei imunosupresoare.…”

Section: Alotransplantul De Membre Pelvineunclassified

Current status of vascularized composite allografts transplant

Grosu-Bularda¹,

Lascăr²,

Teodoreanu³

2019

Ro J Med Pract.

View full text Add to dashboard Cite

RezumatIntroducere. După anul 1998, când a fost efectuat primul transplant de mână în Franţa, la Lyon, s-a produs o dezvoltare neaşteptată a chirurgiei reconstructive de transplant. Transplanturile alogrefelor vascularizate compozite (VCA) se adresează unor pacienţi atent selectionaţi, în instituţii acreditate, pentru îmbunătăţirea prognosticului funcţional şi a calitaţii vieţii acestora. Scopul acestei lucrari este trecerea în revistă a rezultatelor clinice obţinute în transplantul vascularizat compozit la nivel mondial. Metodă. Au fost analizate publicaţiile relevante în domeniul alotransplantului vascularizat compozit, inclusiv datele din cadrul Registrului Internaţional de Transplant de Mână şi Ţesuturi Compozite (International Registry on Hand and Composite Tissue Transplantation:IRHCTT), resursă de mare importanţă în evaluarea globală a transplanturilor tisulare compozite. Rezultate şi discuţii. Până în prezent, au fost efectuate la nivel mondial peste 200 de astfel de proceduri, cu numeroase aplicaţii clinice, incluzând transplanturi ale membrelor toracice uni sau bilaterale, transplant de faţă, laringe, trahee, perete abdominal, membru pelvin, uter şi penis. Având o experienţă clinică de aproape două decenii, cu standardizarea indicaţiilor şi protocoalelor chirurgicale, singurele limitări în ceea ce priveşte utilizarea pe scară largă a alogrefelor vascularizate compozite sunt aspectele imunologice: fiind proceduri non-vitale, devine discutabilă expunerea pacienţilor la terapie imunosupresoare pentru tot restul vieţii, cu efectele adverse legate de administrarea acesteia. Concluzii. Chirurgia reconstructivă de transplant are potenţial să devină un standard terapeutic, fiind unica soluţie reconstructivă în cazul anumitor defecte tisulare complexe, implicând multiple structuri cu importanţă funcţională, imposibil de reparat utilizând tehnicile chirurgicale convenţionale. Rezultatele favorabile atestând fezabilitatea acestor tehnici, depăşirea dilemelor etice, elaborarea unor protocoale chirurgicale şi imunologice standardizate asigură extinderea utilizării alotransplanturilor vascularizate compozite în practica clinică. Cuvinte cheie: transplant, alogrefe vascularizate compozite (VCA), transplant de mână, transplant de faţă, imunosupresie Abstract Introduction. The field of composite tissue allotransplatation became a clinical reality since first hand transplant performed in 1998 at Lyon, France and has been progressing over the past two decades. Vascularized composite allotransplantation (VCA) is now performed for life enhancing indications in a selected group of patients under institutional protocols.Aim. This paper is an attempt to review the outcomes of VCA to date. Method. Analysis of relevant publications of composite tissue allotransplantation was performed, including the International Registry on Hand and Composite Tissue Transplantation (IRHCTT).Results and discussion. To date, there are more than 200 composite tissue allograft transplants performed worldwide, including upper limb, face, larynx, tr...

show abstract

Lessons Learned From the First Quadruple Extremity Transplantation in the World

Cited by 32 publications

References 18 publications

Vascularized composite allotransplantation - a Council of Europe position paper

Vascularized composite allotransplantation - a Council of Europe position paper

Trans-femoral lower limb transplantation in a Sri Lankan patient: a case report and surgical technique

Current status of vascularized composite allografts transplant

Contact Info

Product

Resources

About