On February 24, 2022, Russia attacked its neighboring country of Ukraine. From the early days of what Russian President Putin called a special military operation, fears mounted that the conflict may grow into World War III, effectively ending the world in nuclear Armageddon. This study compares the current views of American and Russian youths on the issues of global nuclear war and nuclear weapons, as well as explores their inclinations toward supporting a first nuclear strike, nuclear retaliation, and their willingness to make personal sacrifices in the event of a nuclear conflict. Drawing upon the theoretical framework of co-orientation theory, the study methodically assesses the levels of agreement, congruency, and accuracy for the populations of both countries on the issues related to the nuclear conflict. The results show that American and Russian youths are currently in a state of imbalanced co-orientation—a newly defined state in the co-orientation theory—when it comes to their opinions on nuclear war and nuclear weapons. In conclusion, the study underscores the urgent need to address this lack of alignment between the two countries, given the potentially catastrophic consequences of nuclear warfare. Therefore, the study draws upon the co-orientation theory’s insights and formulates strategic public diplomacy recommendations, designed to cultivate mutual understanding, and promote constructive dialogue between the people of the United States of America and the Russian Federation.