Leucocyte and Tissue Groups^1

Dausset, J

doi:10.1159/000465121

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…Included were examples of antiserums for the 1, 3, 7, 8 and 9 antigens [4], antiserums defining the 4a, 4b, 5a, 5b, 6a, 6b, 7a, 7b, 7c, 7d, 8a and 9a antigenic deter minants [3] and Ke, DeR, and Pa serums Suspensions of red blood cells (RBC) were prepared from citrated whole blood. Thirty-one blood specimens, obtained from persons whose leukocytes (WBC) had been typed previously, were mailed to New York from Paris and Leiden.…”

Section: Methodsmentioning

confidence: 99%

“…Twenty-six examples of anti-leukocyte and two examples of antineutrophile serums were used in this study. Included were examples of antiserums for the 1,3,7,8 and 9 antigens [4], antiserums defining the 4a, 4b, 5a, 5b, 6a, 6b, 7a, 7b, 7c, 7d, 8a and 9a antigenic determinants [3] Prior t o testing with anti-leukocyte serums, RBC were freed of WBC by washing 10 times with 0.9% NaCl solution. The top layer of the packed RBC was carefully removed after each centrifugation.…”

Section: Methodsmentioning

confidence: 99%

“…Isoantigenic variation in human leukocytes, and specific serums defining several leukocyte antigen systems, have been described [3,4,6,10]. Most of these antigens have been found to occur on the cells of several different organs [1,2,7], some have been limited in their distribution to a specific cell strain [6], but until now none have been demonstrated on erythrocytes.…”

mentioning

confidence: 99%

“…

Isoantigenic variation in human leukocytes, and specific serums defining several leukocyte antigen systems, have been described [3,4,6, 101. Most of these antigens have been found to occur on the cells of several different organs [l, 2, 71, some have been limited in their distribution t o a specific cell strain [6], but until now none have been demonstrated on erythrocytes.This preliminary report will describe hemagglutinating activity of anti-leukocyte serums, the specificity of which differs from that of antibodies defining known red cell blood types.

Methods and MaterialsTwenty-six examples of anti-leukocyte and two examples of antineutrophile serums were used in this study.

…”

mentioning

confidence: 99%

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Hemagglutination by Human Anti-Leukocyte Serums

Rosenfield¹,

Rubinstein²,

Lalezar³

et al. 1967

Vox Sanguinis

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

“…

Methods and MaterialsTwenty-six examples of anti-leukocyte and two examples of antineutrophile serums were used in this study.

…”

mentioning

confidence: 99%

See 2 more Smart Citations

Hemagglutination by Human Anti-Leukocyte Serums

Rosenfield¹,

Rubinstein²,

Lalezar³

et al. 1967

Vox Sanguinis

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Mechanisms of Disease: alloimmunization in renal diseases

2006

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Graft rejection has long been considered the paradigm of renal diseases induced by alloimmunization, particularly alloimmunization directed against HLA antigens. Accumulating evidence indicates that non-HLA immunity also has an important role in clinical transplantation. Targets of alloimmunization include antigens of tubular basement membrane, tubular epithelial cells and endothelial cells. They can be polymorphic allovariants (as shown in the rat) or 'hidden' antigens exposed when the graft is damaged. Alloimmunization can also occur when a person genetically deficient in a renal protein (e.g. the alpha5 (IV) collagen chain in X-linked Alport's syndrome or nephrin in Finnish-type nephrotic syndrome) is transplanted to treat end-stage renal failure. The non-mutated protein in the donor kidney is recognized as a foreign antigen, and the resulting alloimmune response can damage the graft. We have demonstrated that alloimmunity can also affect the native kidney. We have characterized a novel fetomaternal disease in which a genetic defect in the MME gene encoding neutral endopeptidase (NEP) in the mother leads to the development of membranous nephropathy in her fetus (maternal anti-NEP antibodies bind to NEP on fetal podocytes). Our findings raise the possibility that mutations or genetic polyporphisms in MME or other genes expressed by the podocyte are involved in alloimmune-mediated development of membranous nephropathy after kidney or bone marrow transplantation.

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Tissue Alloantigens Present in Human Leukocytes*

Dausset

Iványi

1966

Annals of the New York Academy of Sciences

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Leucocyte and Tissue Groups^1

Cited by 4 publications

References 14 publications

Hemagglutination by Human Anti-Leukocyte Serums

Hemagglutination by Human Anti-Leukocyte Serums

Mechanisms of Disease: alloimmunization in renal diseases

Tissue Alloantigens Present in Human Leukocytes*

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