Leukocyte Motility in Acne conglobata

Abstract

Leukocytes derived from the peripheral blood of 10 patients with acne conglobata demonstrated enhanced chemotactic and random migratory activities in comparison with leukocytes from 10 healthy subjects. This enhancement is most probably secondary to the state of chronic infection and inflammation. These findings probably rule out a defect in leukocyte motility as a cause of the severity of the lesions in acne conglobata.

An in vitro assessment of certain cellular and humoral immune functions in patients with chronic acne. improved leukocyte function and moderate clinical improvement following propranolol therapy in an uncontrolled trial

“…Seven patients had impaired neutrophil chemotactic responsiveness to EAS and of these only one had a markedly increased serum IgE level and two had moderately raised levels. These results differ from the report of Wahba (1978) who foimd increased PMN random and directed migration in ten patients with acne conglobata. These findings may be explained by variations in methodology since the assay used by Wahba (1978) was different from that used in the present study.…”

“…These results differ from the report of Wahba (1978) who foimd increased PMN random and directed migration in ten patients with acne conglobata. These findings may be explained by variations in methodology since the assay used by Wahba (1978) was different from that used in the present study. PMN random migration was not assessed in this project.…”

Neutrophil Functions in Acne conglobata

“…It seems likely that the increased leukotactic responsiveness reported by Wahba [8] may reflect a different technical approach in assessing neutrophil migration in vitro. Besides, our results exclude also any consistent abnormality in the process of ingestion and in the burst of metabolic activity associated with the neutrophil phagocytosis.…”

“…Recently, it has been reported [8] that the circulating neutrophils of patients with acne conglobata are hyperactive in their response to chemotactic stimulation as well as in their random migration, ruling out a defect in neutrophil motility as a possible cause of that chronic disease.…”

Neutrophil Chemotaxis in Patients with Pustulotic Arthro-Osteitis

“…The directed migration of cells along a chemical gradient is termed chemotaxis. The activation of this process appears to be an important mechanism by which immune effector cells settle at sites of inflammation [1], The chemotactic activity of PMNs from peripheral blood was found to be normal in patients with systemic lupus erythematosus [2,3], normal or reduced in patients with rheumatoid arthritis [3][4][5][6], but increased or normal in patients with ankylosing spondylitis, and reactive arthri tis [7][8][9], and in healthy persons with HLA-B27 [7,9], Increased PMN chemotaxis may also occur in patients wdth psoriasis vulgaris [10][11][12], pustular psoriasis [12], pustulosis palmoplantaris (PPP) [13] and severe or sys temic acne [14], The presence of arthropathy does not seem to be associated with en hanced chemotactic activity of PMNs in pa tients with psoriasis vulgaris or pustular psoriasis [11,12]. Investigations on the in fluence of arthropathy in patients with PPP [15,16] and acne [17] have not been per formed.…”