Leukoplakia of the labial commissure

Hogewind, W.F.C.; Waal, I. van der

doi:10.1016/0266-4356(88)90008-3

Cited by 7 publications

(5 citation statements)

References 11 publications

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“…The significantly higher percentage of smokers in the patients of the present study compared to the control group (77% vs 28%) is in accordance with other studies (6,13) where up to 100% of patients with chronic hyperplastic candidosis were stnokers (12). Previous studies have found a high proportion of denture wearers in patients with chronic hyperplastic candidosis (12)(13)(14) and there is good evidence that dentures form a reservoir for candidal infection (15). In addition, the lack of a real pattern of hematologic or nutdtional deficiency or significant undedying systemic disease in the patient group tends to emphasise the importance of local factors.…”

Section: Discussionsupporting

confidence: 93%

Chronic hyperplastic candidosis and secretor status

Darwazeh

Muirhead

et al. 1991

J Oral Pathology Medicine

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A prospective study was undertaken of 22 patients with chronic hyperplastic candidosis and 50 age and sex matched individuals with no evidence of oral mucosal disease. Specifically the relationship between the inherited ability to secrete blood group antigens in saliva and chronic hyperplastic candidosis was investigated. The proportion of non-secretors of blood group antigens was significantly higher in patients with chronic hyperplastic candidosis (68%) compared to the control subjects (38%). The inability to secrete blood group antigens in saliva may therefore be a risk factor in the development of, or persistence of chronic hyperplastic candidosis.

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Section: Discussionsupporting

confidence: 93%

Chronic hyperplastic candidosis and secretor status

Darwazeh

Muirhead

et al. 1991

J Oral Pathology Medicine

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“…The results obtained in the present study are comparable with the study of Cynthia Jane et al in 2007 [15] which clearly show the raise in CIC levels from, NormalcontrolsOral LeukoplakiaOral Submucous Fibrosis.…”

Section: Discussionsupporting

confidence: 92%

“…In the present study oral leukoplakia was completely seen in males only, with 25 subjects (100%) which is exactly matching with the study done by Hogewind WFC and Van Der I in 1989 (100%) [15].…”

Section: Discussionsupporting

confidence: 92%

Estimation of Circulating Immune Complexes in patients with Oral Leukoplakia and Oral Submucous Fibrosis: A Case Control Study

Maheswari¹

2014

JCDR

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“…However, there are surprisingly few systematic histologic investigations of the different variants of oral candidiasis either in immunocompetent or immunocompromized hosts. These include histopathologic studies of candidal leukoplakia in immunocompetent individuals (Cawson, 1966;Cawson and Lehner, 1968;Hogewind and van der Waal, 1988;Williams et al, 1997), the histopathology of Candida-induced denture stomatitis (Budtz-Jörgensen, 1990) and ultrastructural findings in Candida-infected oral mucosa (Nagai et al, 1992).…”

Section: Clinical and Histopathologic Features Of Oral Candidiasismentioning

confidence: 99%

“…Another type of oral candidiasis which may manifest in both the immunocompetent (Hogewind and van der Waal, 1988;Williams et al, 1997) and the immunocompromised (Schmidt-Westhausen et al, 1999), has been variously termed as candidal leukoplakia, hyperplastic candidiasis, Candida-associated leukoplakia or Candida leukoplakia (van der Waal, 1997). It is characterised by a non-homogeneous leukoplakia, the surface of which is usually heavily infiltrated by Candida albicans.…”

Section: Candidal Leukoplakiamentioning

confidence: 99%

Pathology and clinical correlates in oral candidiasis and its variants: a review

2000

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Although Candida albicans is well recognised as the major agent of oral candidiasis, it is not clear why several variants such as pseudomembranous (PC), erythematous (EC) and hyperplastic candidiasis (HC) manifest in different individuals, sometimes singly and on other occasions, in combination. The present review focuses on recent histopathologic and immunocytochemical studies as well as the pathogenic attributes of the yeast, in an attempt to address the following queries. (1) Do histopathologic studies of the different variants of candidiasis in immunocompetent and immunocompromised individuals help explain these varying manifestations? (2) Under what circumstances does oral candidiasis manifest as a pseudomembranous rather than an erythematous lesion or vice versa? (3) Are there differences in immunoreactivity in closely adjacent mucosae so that the variable presentation of such lesions reflect differences in the local mucosal immune system? Recent studies of PC, EC and HC offer some insights into the pathogenic mechanisms involved. Histopathologic and immunohistochemical finding in cases of PC and EC in HIV-infected patients and controls appear to be comparable, with a marked reduction or even an absence of CD4+ cells. The latter phenomenon is marked in PC compared with the EC, and explicable in terms of a breakdown of the local immune response in the former, and a hypersensitivity reaction against Candida antigens in the latter. Hyperplastic candidiasis on the other hand could be considered a superficial cellular reaction against the pathogen, which cannot entirely be eradicated by the systemic or local host immune response. The virulent attributes of theCorrespondence: Peter A Reichart, Abteilung für Oralchirurgie und Zahnärztliche Röntgenologie, Zentrum für Zahnmedizin, Campus Virchow-Klinikum, Universitätsklinikum Charité, Medizinische fungus, such as the production of extracellular proteinases, do significantly differ within and between species and thereby play a contributory role in the genesis of the clinical variants. Although the available data do give a tantalising glimpse of the contributory mechanisms for the aetiopathology of PC, EC and HC, further research is warranted to elucidate response of the host to this ubiquitous fungal pathogen. Oral Diseases (2000) 6, 85-91

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Leukoplakia of the labial commissure

Cited by 7 publications

References 11 publications

Chronic hyperplastic candidosis and secretor status

Chronic hyperplastic candidosis and secretor status

Estimation of Circulating Immune Complexes in patients with Oral Leukoplakia and Oral Submucous Fibrosis: A Case Control Study

Pathology and clinical correlates in oral candidiasis and its variants: a review

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