Levamisole in the treatment of ascariasis in children

Lionel, N. D. W.; Mirando, E. H.; Nanayakkara, J; Soysa, Preethi

doi:10.1136/bmj.4.5679.340

Cited by 31 publications

(7 citation statements)

References 2 publications

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“…This fact was confirmed by GATTI et al (1969), LIONEL et al (1969, and DDRR (1969 todes and known to be a highly efficient individual and industrial dewormer in pig farms, was of itself a candidate for use in humans (BRUGMANS et al 1971). It was the more so that this drug, poorly absorbed from the intestinal tract, was almost pharmacologically inert.…”

Section: State Of the Artsupporting

confidence: 65%

Chemotherapy of Gastrointestinal Nematodiasis in Man

Janssens¹

1985

Chemotherapy of Gastrointestinal Helminths

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Section: State Of the Artsupporting

confidence: 65%

Chemotherapy of Gastrointestinal Nematodiasis in Man

Janssens¹

1985

Chemotherapy of Gastrointestinal Helminths

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“…Reported adverse reactions include occasional vomiting (5%), dizziness (3%), headache (3%), and weakness (2%); all such reactions were mild and transient [37]–[39]. No abnormalities in haematological laboratory tests have been detected with a single dose calculated on the basis of weight (2.5 mg/kg).…”

Section: Use Of Anthelminthics In Children Undermentioning

confidence: 99%

“…No literature was found specifically on the use of levamisole in PSAC; however, levamisole has been used for mass administration in China, Iran, Vietnam, Brazil, Kenya, and Nigeria. Reported adverse reactions include occasional vomiting (5%), dizziness (3%), headache (3%), and weakness (2%); all such reactions were mild and transient [37] – [39] . No abnormalities in haematological laboratory tests have been detected with a single dose calculated on the basis of weight (2.5 mg/kg).…”

Section: Use Of Anthelminthics In Children Undermentioning

confidence: 99%

Controlling Soil-Transmitted Helminthiasis in Pre-School-Age Children through Preventive Chemotherapy

et al. 2008

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Pre-school age children account for 10%–20% of the 2 billion people worldwide who are infected with soil-transmitted helminths (STHs): Ascaris lumbricoides (roundworm), Trichuris trichiura (whipworm), and Ancylostoma duodenale/Necator americanus (hookworms). Through a systematic review of the published literature and using information collated at World Health Organization headquarters, this paper summarizes the available evidence to support the recommendation that pre-school children should be included in regular deworming programmes. The first section describes the burden of STH disease in this age group, followed by a summary of how infection impacts iron status, growth, vitamin A status, and cognitive development and how STHs may exacerbate other high mortality infections. The second section explores the safety of the drugs themselves, given alone or co-administered, drug efficacy, and the importance of safe administration. The third section provides country-based evidence to demonstrate improved health outcomes after STH treatment. The final section provides country experiences in scaling up coverage of pre-school children by using other large scale public health interventions, including vitamin A programmes, immunization campaigns, and Child Health days. The paper concludes with a number of open research questions and a summary of some of the operational challenges that still need to be addressed.

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“…Levamisole (Lms) is a synthetic thiazole, originally used as an anti-helminthic drug (Lionel et al ., 1969; Scherb, 1969). Also, scientists have shown its use as an immunomodulatory agent with beneficial or harmful outcomes, depending on the dose regimen, the timing of the treatment and the immune status of the patient (Brunner and Muscoplat, 1980).…”

Section: Introductionmentioning

confidence: 99%

Impact of levamisole in co-administration with benznidazole on experimental Chagas disease

et al. 2019

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Levamisole (Lms) is an anthelminthic drug with immunomodulatory activity. Chagas disease (CD) is caused by Trypanosoma cruzi and there is very low access to the drugs available, benznidazole (Bz) and nifurtimox, both far from ideal. In a drug-repurposing strategy to test potential activity as antiparasitic and immunomodulatory agent for CD, Lms was assayed on acute T. cruzi murine infection, alone and in co-administration with Bz. During protocol standardization, 100 and 10 mpk of Bz given for five consecutive days resulted in parasitaemia suppression and 100% animal survival only with the highest dose. Flow cytometry showed that both optimal (100 mpk) and suboptimal (10 mpk) doses of Bz equally decreased the plasma levels of cytokines commonly elevated in this acute infection model. Lms alone (10–0.5 mpk) did not decrease parasitaemia nor mortality rates. Co-administration was investigated using the suboptimal dose of Bz and different doses of Lms. While Bz 10 mpk did not alter parasitaemia, the combo partially reduced it but only slightly promoted animal survival. This effect could be related to Th1-response modulation since interleukin-6 and interferon-γ were higher after treatment with the combo.

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Levamisole in the treatment of ascariasis in children

Cited by 31 publications

References 2 publications

Chemotherapy of Gastrointestinal Nematodiasis in Man

Chemotherapy of Gastrointestinal Nematodiasis in Man

Controlling Soil-Transmitted Helminthiasis in Pre-School-Age Children through Preventive Chemotherapy

Impact of levamisole in co-administration with benznidazole on experimental Chagas disease

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