Level of Uric Acid in Blood Serum of New Pulmonary Tuberculosis Patients With Multiple Drug Resistance

Абдуллаев, Р. Ю.; Komissarova, Oksana; Chumakova, Elena; Odinets, V.S.

doi:10.21292/2075-1230-2017-95-4-31-36

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…It has been reported that patients with TB tend to exhibit increased levels of CRP, erythrocyte sedimentation rate (ESR), and UA, and low levels of Hb (25). An increased UA level was observed in 28.2% of men and 37.5% of women prior to chemotherapy, and more often during the first 2 months of treatment both in men and women, which suffered from multiple drug-resistant pulmonary TB (26). In the present study, serum UA was revealed to be at a significantly higher level in TB (FDR <0.001), with an OR value of 0.36 (P=2.5E-05) compared with PN (Table II), indicating that it may be a specific protective factor in patients with TB.…”

Section: Discussionmentioning

confidence: 99%

Construction of a risk model and deep learning network based on patients with active pulmonary tuberculosis and pulmonary inflammation

Zeng

Xie

et al. 2023

Biomed Rep

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Most patients with active pulmonary tuberculosis (TB) are difficult to be differentiated from pneumonia (PN), especially those with acid-fast bacillus smear-negative (AFB -) and interferon-γ release assay-positive (IGRA + ) results. Thus, the aim of the present study was to develop a risk model of low-cost and rapid test for the diagnosis of AFB -IGRA + TB from PN. A total of 41 laboratory variables of 204 AFB -IGRA + TB and 156 PN participants were retrospectively analyzed. Candidate variables were identified by t-statistic test and univariate logistic model. The logistic regression analysis was used to construct the multivariate risk model and nomogram with internal and external validation. A total of 13 statistically differential variables were compared between AFB -IGRA + TB and PN by false discovery rate (FDR) and odds ratio (OR). By integrating five variables, including age, uric acid (UA), albumin (ALB), hemoglobin (Hb) and white blood cell counts (WBC), a multivariate risk model with a concordance index (C-index) of 0.7 (95% CI: 0.61, 0.8) was constructed. The nomogram showed that UA and Hb acted as protective factors with an OR <1, while age, WBC and ALB were risk factors for TB occurrence. Internal and external validation revealed that nomogram prediction was consistent with the actual observations. Collectively, it was revealed that an integration of five biomarkers (age, UA, ALB, Hb and WBC) may be used to quickly predict TB in AFB -IGRA + clinical samples from PN.

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Section: Discussionmentioning

confidence: 99%

Construction of a risk model and deep learning network based on patients with active pulmonary tuberculosis and pulmonary inflammation

Zeng

Xie

et al. 2023

Biomed Rep

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“…При лечении туберкулеза важно не только достичь эффективного результата, но и снизить вероятность развития нежелательных побочных реакций. Ряд работ посвящен изучению переносимости как отдельных противотуберкулезных препаратов, так и их комбинаций, а также способам мониторирования и коррекции нежелательных побочных эффектов [1,3,4,8,9,10]. Вопросы переносимости противотуберкулезных препаратов при проведении химиотерапии у детей с множественной и широкой лекарственной устойчивостью (МЛУ/ШЛУ) M. tuberculosis (МБТ) в литературе мало освещены несмотря на важность этого вопроса [2,7].…”

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Tolerability of individual chemotherapy regimens in children suffering from respiratory tuberculosis and exposed to multiple and extensive drug resistant tuberculosis

Губкина¹,

Хохлова²,

Петракова³

et al. 2021

Tuberk. bolezni lëgk.

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The objective of the study: to assess the tolerability of anti-tuberculosis drugs (TB drugs) in children with respiratory tuberculosis and exposure to multiple and extensive drug resistant tuberculosis treated by individual chemotherapy (CT) regimens.Subjects and methods: Totally, 89 children (2-12 years old) with respiratory tuberculosis, they all were exposed to multiple and extensive drug resistant tuberculosis. Patients were divided into three groups: Group 1 (17 patients) – minor forms, the chemotherapy regimen consisted of 3 TB drugs, Group 2 (35 patients) – limited lesions, the chemotherapy regimen consisted of 4 TB drugs, Group 3 (37 patients) – the disseminated disease, the chemotherapy regimen consisted of 5 TB drugs. The following TB drugs were used in Group 1: Pto ‒ in 94.1%, Z ‒ in 76.5%, PAS ‒ in 76.5%, Am – in 35.3%, E – in 17.6%, and Cs – in 5.9% of cases. In Group 2: PAS – in 94.3%, Z – in 80.0%, Pto – in 68.6%, Am – in 48.6% and Fq – in 45.7%, Cs ‒ in 37.1%, and E – in 25.7% of cases. In Group 3: Z – in 97.3%, PAS – in 89.2%, Pto – in 81.1%, Fq ‒ in 73.0%, Am – in 70.3%, Cs – in 51.4%, and E – in 37.8% of cases.Results. In general, chemotherapy was well tolerated by 50.6% (45 people) of children, and poorly - by 49.4% (44 people), p> 0.05. Toxic reactions were observed statistically significantly more often versus allergic ones: 63.6 ± 7.3% (28 persons) and 36.4 ± 7.3% (16 persons), p < 0.05. The culprits drugs causing toxic reactions were prothionamide (24 patients), pyrazinamide (2 patients), cycloserine (1 patients), and levofloxacin (1 patients), toxic reactions - amikacin (16 patients). Adverse reactions statistically significantly more often occurred when five-component regimen (67.6 ± 7.7%) was used versus three- and four-component regimens (29.4 ± 11.4 and 40.0 ± 8.3%, respectively), p <0.05.

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Nephrotoxic Characteristics of Anti-Tuberculosis Drugs

Можокина¹,

Samoilova²,

ZАNGIEVА³

2019

TIBL

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ФГБУ «Национальный медицинский исследовательский центр фтизиопульмонологии и инфекционных заболеваний» МЗ РФ, Москва, РФ В обзоре представлен анализ данных литературы о частоте нежелательных реакций со стороны почек при химиотерапии больных туберкулезом. Рассмотрены наиболее значимые патофизиологические механизмы развития лекарственной нефротоксичности. Показаны особенности нефротоксического действия аминогликозидов, капреомицина, рифампицина, пиразинамида, фторхинолонов, линезолида. Сделано заключение о необходимости регулярного клинико-лабораторного мониторинга функции почек для своевременного выявления нефротоксических реакций.

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Level of Uric Acid in Blood Serum of New Pulmonary Tuberculosis Patients With Multiple Drug Resistance

Cited by 5 publications

References 7 publications

Construction of a risk model and deep learning network based on patients with active pulmonary tuberculosis and pulmonary inflammation

Construction of a risk model and deep learning network based on patients with active pulmonary tuberculosis and pulmonary inflammation

Tolerability of individual chemotherapy regimens in children suffering from respiratory tuberculosis and exposed to multiple and extensive drug resistant tuberculosis

Nephrotoxic Characteristics of Anti-Tuberculosis Drugs

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