п е р с о н и ф и ц и р о в а н н ы е п о д х о д ы к в ы б о р у р е ж и м а х и м и о т е р а п и и т у б е р к у л е з а о р г а н о в д ы х а н и я у д е т е й и з э п и д е м и ч е с к и х о ч а г о в т у б е р к у л е з а с м н о ж е с т в е н н о й л е к а р с т в е н н о й у с т о й ч и в о с т ь ю в о з б у д и т е л я

The objective: to analyze the course of the new coronavirus infection (COVID-19) in children with active respiratory tuberculosis. Subjects and methods. The article describes results of retrospective analysis of the course of the new coronavirus infection in 25 children (3-12 years old) with active respiratory tuberculosis during the outbreak of COVID-19 in an in-patient TB unit.Results. 24 (96%) persons got infected after the close exposure to the coronavirus infection, and 1 (4%) child didn't get infected. The diagnosis was verified by polymerase chain reaction (detection of RNK of SARS-CoV-2) in 33.3%, by enzyme immunoassay (detection of IgG antibodies to SARS-CoV-2 in 1 month after quarantine removal) in 100%. 58.3% of children with respiratory tuberculosis (14 people) infected with coronavirus infection had minimal respiratory symptoms, that did not differ from signs of other respiratory viral infections; clinical manifestations of the disease were completely absent in 41.7% (10) patients. Coronavirus pneumonia was diagnosed in 4 (16.7%) children who suffered from COVID-19, they had no clinical signs of lower respiratory tract disorders and no body temperature increase; 3 patients had no signs of respiratory viral infection; in all cases, the lung damage detected by computed tomography didn't exceed 10%. In 2 months after the removal of quarantine, no IgG antibodies to SARS-CoV-2 were detected in 2 out of 10 examined children (20.0%), thus there was a chance for re-infection. No mutual aggravating effect of coronavirus infection and tuberculosis was revealed in their combination over the entire observation period (4 months).

The objective of the article: to demonstrate the peculiarities of tuberculosis in young children and the high probability of the transition of primary tuberculosis in a child from a sociopathic family to a chronic process due to the absence of medical supervision after chemotherapy. The article describes a clinical case demonstrating the influence of dysfunctional social risk factors on the development of chronic primary tuberculosis in a child. The authors provide a detailed information of medical care to the child, including surgery.