Levels of dimethylarginines and cytokines in mild and severe preeclampsia

Ellis, Joy; Wennerholm, Ulla‐Britt; Bengtsson, Anders; Lilja, Håkan; Pettersson, Anders; Sultan, Bo; Wennergren, Margareta; Hagberg, Henrik

doi:10.1034/j.1600-0412.2001.800703.x

Cited by 63 publications

(45 citation statements)

References 36 publications

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“…In pregnant SLE women, IL-6 serum concentrations were higher than in controls with a peak in the first trimester, 43 while IL-10 resulted persistently higher in patients with SLE, both before and during pregnancy. 47,48 In conclusion, the present findings showed an increased cytokine profile in pregnant women with SLE, with high levels of Th17 and activin A suggesting a possible contribution of placenta to immune adaptation in the pregnant SLE women. 47,48 In conclusion, the present findings showed an increased cytokine profile in pregnant women with SLE, with high levels of Th17 and activin A suggesting a possible contribution of placenta to immune adaptation in the pregnant SLE women.…”

Section: Discussionsupporting

confidence: 58%

High Levels of Maternal Serum IL‐17 and Activin A in Pregnant Women Affected by Systemic Lupus Erythematosus

Torricelli

Bellisai

Novembri

et al. 2011

American J Rep Immunol

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Section: Discussionsupporting

confidence: 58%

High Levels of Maternal Serum IL‐17 and Activin A in Pregnant Women Affected by Systemic Lupus Erythematosus

Torricelli

Bellisai

Novembri

et al. 2011

American J Rep Immunol

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“…That ADMA levels are higher than normal in preeclamptic patients supports this idea. 12,13 Our findings differ from those of Holden et al," who reported that during a normal pregnancy maternal plasma ADMA reaches a minimum by the end of the first trimester, then increases with increasing gestational age. In addition, they found that the plasma ADMA concentration correlated significantly with blood pressure at all stages of normal pregnancy and that changes in the level of circulating ADMA contribute significantly to the changes in blood pressure seen in both normal and preeclamptic pregnancies.…”

Section: Discussioncontrasting

confidence: 99%

Asymmetric Dimethylarginine, an Endogenous Inhibitor of Nitric Oxide Synthase, in Maternal and Fetal Circulation

Maeda

Yoshimura

Okamura

2003

Journal of the Society for Gynecologic Investigation

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Pronounced dilation of the maternal vasculature occurs during normal pregnancy. Likewise, low resistance characterizes the fetoplacental circulation. Nitric oxide released by endothelial cells is a potent vasodilator known to be a key modulator of both maternal and fetal vascular tone. However, the mechanisms underlying the maternal circulatory adaptations and the low resistance of the fetal circulation remain unknown. The aim of the present study was to compare levels of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, in the maternal and fetal circulations. High performance liquid chromatography was used to measure asymmetric ADMA in the maternal and umbilical venous plasma. Plasma ADMA levels during the first trimester were 0.29 +/- 0.05, the third trimester before term 0.29 +/- 0.05, and at term 0.32 +/- 0.05 nmol/mL, which were significantly (P <.05) lower than the levels measured in nonpregnant women (0.41 +/- 0.06 nmol/mL). By contrast, ADMA levels in umbilical venous plasma averaged 1.02 +/- 0.18 nmol/mL, significantly (P <.005) higher than maternal levels. Unlike ADMA, levels of plasma L-arginine, the nitric oxide precursor, did not significantly differ among nonpregnant and pregnant women and the fetus.During pregnancy, maternal hemodynamics are modulated, at least in part, by a reduction in ADMA. Conversely, the low resistance to umbilical blood flow is maintained despite substantially higher fetal ADMA levels. Thus, the predominant mechanisms regulating the maternal and fetal circulation apparently differ.

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“…Increase of ADMA in endothelium-dependent vascular dysfunction was detected in diabetic, hypertensive, and hypercholesterolemic patients [20, 47, 48]. It is reported that ADMA may decrease at the beginning of normal pregnancy [49], but under the preeclampsia condition its concentration increases [50–52], which may be associated with the disease intensity [50]. It seems that ADMA is involved in preeclampsia pathogenesis because inhibition of NO synthesis in rodents during pregnancy produces signs similar to those of preeclampsia [53–55].…”

Section: Discussionmentioning

confidence: 99%

Serum Levels of Asymmetric Dimethylarginine, Vascular Endothelial Growth Factor, and Nitric Oxide Metabolite Levels in Preeclampsia Patients

Noorbakhsh

Kianpour

Nematbakhsh

2013

ISRN Obstetrics and Gynecology

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Background. Hypertensive disorder generally complicates 5–10 percent of all pregnancies. Angiogenic growth factors may be helpful for the diagnosis and prediction of preeclampsia. Therefore, in this study we attempted to determine the serum levels of asymmetric dimethylarginine (ADMA), vascular endothelial growth factor (VEGF), and nitric oxide (NO) metabolite (nitrite) in preeclampsia patients and compared the levels with those obtained from normal pregnant women. Methods. Ninety pregnant women (19–33 years old) in two groups of preeclampsia and normal were considered during 2012. The levels of ADMA, VEGF, and nitrite were measured in maternal serum samples using ELISA kits. Results. Significant increase of VEGF and nitrite levels was observed in preeclampsia patients when compared with other groups (P < 0.05). The serum level of ADMA demonstrated a similar increased trend in preeclampsia patients; however, the increase was not statistically significant (P = 0.08). Conclusion. The findings reveal that the elevation of serum levels of VEGF and nitrite and possibly ADMA may be involved in the pathogenesis of preeclampsia.

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Levels of dimethylarginines and cytokines in mild and severe preeclampsia

Cited by 63 publications

References 36 publications

High Levels of Maternal Serum IL‐17 and Activin A in Pregnant Women Affected by Systemic Lupus Erythematosus

High Levels of Maternal Serum IL‐17 and Activin A in Pregnant Women Affected by Systemic Lupus Erythematosus

Asymmetric Dimethylarginine, an Endogenous Inhibitor of Nitric Oxide Synthase, in Maternal and Fetal Circulation

Serum Levels of Asymmetric Dimethylarginine, Vascular Endothelial Growth Factor, and Nitric Oxide Metabolite Levels in Preeclampsia Patients

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