Levels of serum leptin in patients with primary hand osteoarthritis

Abaunza, Renán Alberto Morales; Rojas, Ángela; Rojas, Cilia; Motta, Orfa; Atuesta, Javier; Álzate, Juan Pablo; Herrera, Federico Rondón

doi:10.1016/j.rcreue.2019.12.005

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…Obesity is known to increase the incidence and progression of OA (King et al, 2013). Multiple studies demonstrate increased adipokines including serum leptin levels associated with the disease (de Boer et al, 2012;Tootsi et al, 2016;Morales Abaunza et al, 2020). Leptin has been shown to upregulate proteolytic enzymes such as MMP-1 and MMP-3 in articular cartilage and correlates with their levels in the synovial fluid of OA patients, suggesting a potential for an enhanced catabolic effect on OA cartilage (Koskinen et al, 2011).…”

Section: Osteoarthritismentioning

confidence: 99%

Bone Angiogenesis and Vascular Niche Remodeling in Stress, Aging, and Diseases

Stucker

Chen

Watt

et al. 2020

Front. Cell Dev. Biol.

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The bone marrow (BM) vascular niche microenvironments harbor stem and progenitor cells of various lineages. Bone angiogenesis is distinct and involves tissue-specific signals. The nurturing vascular niches in the BM are complex and heterogenous consisting of distinct vascular and perivascular cell types that provide crucial signals for the maintenance of stem and progenitor cells. Growing evidence suggests that the BM niche is highly sensitive to stress. Aging, inflammation and other stress factors induce changes in BM niche cells and their crosstalk with tissue cells leading to perturbed hematopoiesis, bone angiogenesis and bone formation. Defining vascular niche remodeling under stress conditions will improve our understanding of the BM vascular niche and its role in homeostasis and disease. Therefore, this review provides an overview of the current understanding of the BM vascular niches for hematopoietic stem cells and their malfunction during aging, bone loss diseases, arthritis and metastasis.

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Section: Osteoarthritismentioning

confidence: 99%

Bone Angiogenesis and Vascular Niche Remodeling in Stress, Aging, and Diseases

Stucker

Chen

Watt

et al. 2020

Front. Cell Dev. Biol.

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“…Similar results were reported in the HANES III cross-sectional study in 2477 patients where no significant difference was recorded in serum leptin levels between asymptomatic, symptomatic, and no hand OA in both genders [ 55 ]. By contrast, Morales Abaunza et al reported a significant elevation of serum leptin levels in hand OA patients in comparison with healthy controls [ 56 ].…”

Section: Leptin and Osteoarthritismentioning

confidence: 99%

Leptin in Osteoarthritis and Rheumatoid Arthritis: Player or Bystander?

Eldjoudi

Cordero-Barreal

González-Rodríguez

et al. 2022

IJMS

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White adipose tissue (WAT) is a specialized tissue whose main function is lipid synthesis and triglyceride storage. It is now considered as an active organ secreting a plethora of hormones and cytokines namely adipokines. Discovered in 1994, leptin has emerged as a key molecule with pleiotropic functions. It is primarily recognized for its role in regulating energy homeostasis and food intake. Currently, further evidence suggests its potent role in reproduction, glucose metabolism, hematopoiesis, and interaction with the immune system. It is implicated in both innate and adaptive immunity, and it is reported to contribute, with other adipokines, in the cross-talking networks involved in the pathogenesis of chronic inflammation and immune-related diseases of the musculo-skeletal system such as osteoarthritis (OA) and rheumatoid arthritis (RA). In this review, we summarize the most recent findings concerning the involvement of leptin in immunity and inflammatory responses in OA and RA.

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Levels of serum leptin in patients with primary hand osteoarthritis

Cited by 2 publications

References 20 publications

Bone Angiogenesis and Vascular Niche Remodeling in Stress, Aging, and Diseases

Bone Angiogenesis and Vascular Niche Remodeling in Stress, Aging, and Diseases

Leptin in Osteoarthritis and Rheumatoid Arthritis: Player or Bystander?

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