Levels of serum trace elements in ischemic stroke patients

Gönüllü, Hayriye; Karadaş, Sevdegül; Milanlıoğlu, Aysel; Gönüllü, Edip; Katı, Celal; Demır, Halit

doi:10.5835/jecm.omu.30.04.004

Cited by 4 publications

(1 citation statement)

References 23 publications

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“…In this regard, Gonullu et al Study, demonstrated that stroke and its subgroups associated with some risk factors such as HTN, DM, and also IHD, HLP [28]. Ahangar et al reported that hypertension had significantly associated with hemorrhagic stroke [29].…”

Section: The Role Of Mineral Serum Level In Risk Factor Of Stroke Bamentioning

confidence: 99%

The Role of Mineral Serum Level in Risk Factor of Stroke. Babol, North of Iran

Ahangar¹,

Khafri²,

Saadat³

et al. 2019

J Neurol Exp Neurosci

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Background: The relationship between stroke and mineral status is inconsistent. With regard to doubt in the role of mineral, this study was conducted. Material and Method: This cross-sectional study on 216 stroke patients who referred to the Ayatollah Rouhani Hospital of Babol over one-year period were conducted. Serum level of calcium (Ca), magnesium (Mg), Vitamin D (VD) were measured. Chi-square or Fisher exact test in spss 23 used. Result: Difference of hemorrhagic subtype was statistically significant in hypertensive patients (20(87%) ICH vs. 1(12.5%) SAH, p = 0.001). In thrombotic patients, 98 cases (89%) low VD vs. 12 cases (10.9%) normal VD, (p = 0.001) were seen. Also, low VD was more seen significantly in DM patients 72(90%) in compare to non-DM patients 96(72.7%), (p = 0.003). Of 120 cases (56.3%) who had HTN, 103 cases (85.8%) low VD vs. 17 cases (14.2%) normal VD, (p = 0.01), 68 cases (57.1%) hypo calcemic vs. 45 cases (37.8%) normal Ca serum level, (p < 0.0001) and 57 cases (49.1%) hypomagnesemia vs. 59 cases (50.9%) normal magnesium (p = 0.04) were seen. Difference in sex was statistically significant with hypomagnesemia (49 cases (53.8%) male vs. 38 cases (33.9%) female, p = 0.007). Hypomagnesemia were seen in 87 cases (40.8%) that 49 cases of this were hypo-calcemic (56.3%), (p = 0.03). Differences in magnesium with VD was statistically significant (170 cases (79.4%) low VD vs. 44 cases (20.6%) normal, p = 0.007). Conclusion: Low VD in thrombotic and diabetic patients, low Ca and VD in hypertensive patients and hypocalcemia were more seen in hypermagnesemic patients. Preventive policies such as screening of mineral serum level are suggested.

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Section: The Role Of Mineral Serum Level In Risk Factor Of Stroke Bamentioning

confidence: 99%

The Role of Mineral Serum Level in Risk Factor of Stroke. Babol, North of Iran

Ahangar¹,

Khafri²,

Saadat³

et al. 2019

J Neurol Exp Neurosci

View full text Add to dashboard Cite

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Serum Trace Element Profiles, Prolactin, and Cortisol in Transient Ischemic Attack Patients

Klimenko

Skalny

Turna

et al. 2015

Biol Trace Elem Res

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The primary aim of the present study was to assess the association between trace element status, brain damage biomarkers, cortisol, and prolactin levels in transient ischemic attack (TIA) patients. Ten male and 10 female TIA patients were involved in this study. Age, gender, and BMI-matched volunteers served as the respective control group. Serum samples were examined for complement components C4 and C3a, vascular endothelial growth factor (VEGF), S100B, NR2 antibodies (NR2Ab), total antioxidant status (TAS), cortisol, and prolactin. Trace element concentration in serum samples was assessed using inductively coupled plasma mass spectrometry at NexION 300D. The obtained data indicate that both male and female TIA patients were characterized by the increased C4 and prolactin concentrations. At the same time, serum VEGF levels were elevated in only men, whereas TAS values were decreased in women with TIA. Serum cortisol concentrations were significantly increased only in female TIA patients. Men and women with TIA were characterized by a 32 and 44 % decrease in serum Fe content. A two- and threefold increase in serum V content was observed in TIA females and males, respectively. Women with TIA had 60 % higher values of serum B, whereas male patients were characterized by a sevonfold increase in boron content in comparison to the control values. TIA also resulted in decreased serum Cu content in women and elevation of I, Li, Mn, Se, Zn, As, Pb, Ni, and Sr levels in men. Correlation analysis revealed a significant association between trace elements concentration and the studied parameters.

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