Levels of Zinc, Iron, and Copper in Patients with Pseudoexfoliative Cataract

Cumurcu, Tongabay; Mendil, Durali; Etikán, Ílker

doi:10.1177/112067210601600408

Cited by 28 publications

(20 citation statements)

References 26 publications

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“…An imbalance of MMPs and their inhibitors (TIMPs) is thought to be involved in the pathologic accumulation of PEX material due to insufficient matrix degradation. Another study by Yildirim et al evaluated the levels of zinc and copper in PEX lenses in comparison to normal lenses and demonstrated a significant decrease of zinc in the study group [9]. These results indicate a zinc deficiency in these patients which could lead to a malfunction of zinc-dependent enzymes against oxidative stress, such as superoxidase dismutase (SOD).…”

Section: Discussionmentioning

confidence: 96%

“…Cataractous lenses, on the other hand, with special reference to trace element content and PEX syndrome were initially examined by Lakomaa and Eklund [7] and recently by Yildirim et al [8]. Cumurcu et al also determined zinc, copper, and iron in patients with PEX syndrome [9]. All three studies used the atomic absorption spectrometry (AAS) method for the measurements.…”

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confidence: 99%

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Application of Anodic Stripping Voltammetry for Zinc, Copper, and Cadmium Quantification in the Aqueous Humor: Implications of Pseudoexfoliation Syndrome

Panteli

Kanellopoulou

Gartaganis

et al. 2009

Biol Trace Elem Res

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Anodic stripping voltammetric (ASV) procedure, using mercury film electrode, was optimized and applied to determine the concentrations of zinc, cadmium, and copper in the aqueous humor. Concentration levels as low as 1 ppb of the test metals was possible to be detected using short electrolysis times (120 s) and microquantities of aqueous humor (up to 35 μL). As a first application of the voltammetric analysis of trace metals in the aqueous humor, the role of the three selected trace elements in the pseudoexfoliation (PEX) syndrome was examined. Samples from aqueous humor were collected during cataract extraction from patients with and without PEX. The zinc and copper concentration levels in the aqueous humor did not show statistically significant difference in the study and control group. Cadmium was detected in a small number of samples, without however statistical differences between the two groups. ASV proved to be a highly precise and sensitive tool for the quantification of heavy metal ions in aqueous humor. Further studies may lead to useful conclusions for the role of zinc, copper, or cadmium in PEX syndrome.

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Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

Application of Anodic Stripping Voltammetry for Zinc, Copper, and Cadmium Quantification in the Aqueous Humor: Implications of Pseudoexfoliation Syndrome

Panteli

Kanellopoulou

Gartaganis

et al. 2009

Biol Trace Elem Res

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“…29,30 We have also found higher levels of copper and zinc in the aqueous humour in patients with PEX. 31 Reniewska et al have reported that posttranslational modification of proteins in PEX cataract and other conformational diseases, such as AD and amyloidoses, causes conformational changes and aggregation of these proteins in the tissues. 11 Our findings in the present study also support an association between PEX and AD.…”

Section: Discussionmentioning

confidence: 98%

Is There Any Relation Between Pseudoexfoliation Syndrome and Alzheimer’s Type Dementia?

Cumurcu

Dorak

Cumurcu

et al. 2013

Seminars in Ophthalmology

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“…This is correlated with cataractogenesis [53]. The level of copper generally increases with aging and in sex ratio females accumulate more amounts of copper in the diseased phenotype [54]. An increase in zinc ion concentration has also been reported in cataract samples [55] [49].…”

Section: Intrinsic Cell Biology: Mineral Metabolismmentioning

confidence: 91%

A Comprehensive Review of Molecular Biology and Genetics of Cataract

Wasnik¹,

Gandhi²,

Patil³

et al. 2021

Int. j. res. appl. sci. biotechnol.

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Cataract is one of the oldest diseases. Even in the 21st century, the disease is often neglected and treated as an insignificant threat. Although the facts and figures account for the opposite, it is found that globally cataract holds for more than 50% of blindness. Cataract is also one of the first five immediate focus areas of a global Initiative called 'Vision 2020', which intends to eradicate preventable blindness by 2020. The disease is termed as multifactorial; has various extrinsic environmental and intrinsic cell biology factors determining its progress. Over the years, enormous progress has been made towards cataract including the identification of its risk factors. Yet the current scientific knowledge is far from developing a proven preventive or pharmacological strategy for it. The surgical method has been the only way to cure cataract by far. In this paper, we tried to give a comprehensive bird eye view for the disease; we have (a) reviewed briefly the recent progress in delineating the molecular biology and risk factors of cataract (b) delved into genetics of the cataract and overviewed crucial gene families related to the disease identified through single-gene mutations and Genome-Wide Association Studies (GWAS).

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Levels of Zinc, Iron, and Copper in Patients with Pseudoexfoliative Cataract

Abstract: Zinc, iron, and especially copper may play a role in PEX syndrome.

Cited by 28 publications

References 26 publications

Application of Anodic Stripping Voltammetry for Zinc, Copper, and Cadmium Quantification in the Aqueous Humor: Implications of Pseudoexfoliation Syndrome

Application of Anodic Stripping Voltammetry for Zinc, Copper, and Cadmium Quantification in the Aqueous Humor: Implications of Pseudoexfoliation Syndrome

Is There Any Relation Between Pseudoexfoliation Syndrome and Alzheimer’s Type Dementia?

A Comprehensive Review of Molecular Biology and Genetics of Cataract

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