Lever pressing for pups: Evidence for hormonal influence upon maternal behavior of mice

Hauser, Herbert; Gandelman, Ronald

doi:10.1016/0018-506x(85)90041-8

Cited by 74 publications

(74 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pups' increasing size and functional capacity coincides with a dramatic reduction in maternal behavior (Bridges et al 1972;Reisbick et al 1975;Stern and Mackinnon 1978), while young pups increase the frequency and quality of maternal behavior (Noirot 1964a(Noirot , b, 1965Stern and Mackinnon 1978) and activate dopaminergic reward circuits in the brain (Ferris et al 2005). However, maternal behavior and motivation do not covary in the postpartum dam (Hauser and Gandelman 1985;Mattson et al 2003). As dams prefer either young or old (age-matched) pups equally in a dual-choice CPP procedure (Wansaw and Morrell, unpublished observations), maternal motivation may be driven not by pups but by undetermined physiological or behavioral changes in the dam that subsequently affect her responsivity to pups across multiple developmental time points.…”

Section: Conditioned Place Preferencementioning

confidence: 99%

“…Pups, the second unconditioned stimulus used in the present study, can be uniquely and highly rewarding to the postpartum dam (Wilsoncroft 1969;Hauser and Gandelman 1985;Fleming et al 1994;Magnusson and Fleming 1995;Lee et al 2000;Wansaw et al 2003b;Ferris et al 2005). Early postpartum dams prefer chambers paired with pups over pup-sized neutral rubber objects after just 15 min of deprivation from their pups (Wansaw et al 2003b) and voluntarily stay in the nest for the longest periods of time Ader 1969, 1974;Ader and Grota 1970;Stern and Keer 2002); in contrast, late postpartum dams strongly prefer chambers paired with alternative nonpup stimuli, even after 12 h of pup deprivation, and leave their pups for increasingly longer intervals.…”

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Increasing the incentive salience of cocaine challenges preference for pup- over cocaine-associated stimuli during early postpartum: place preference and locomotor analyses in the lactating female rat

Seip

Morrell

2007

Psychopharmacology

View full text Add to dashboard Cite

Rationale/Objectives-Prior studies using a dual-choice conditioned place preference (CPP) procedure revealed that postpartum female rats (dams) strongly prefer chambers associated with pups over those associated with subcutaneously administered cocaine almost exclusively during early but not late postpartum (Mattson et al. 2001). The present study examines whether early postpartum dams retain strong pup-associated chamber preference when contrasted with a cocaine stimulus of greater incentive salience (intraperitoneal [IP] injections with brief conditioning sessions). Locomotor rate was measured during conditioning (stimuli-present) and test (stimulus-absent) sessions.Materials and methods-A three-chambered CPP apparatus was used to compare preferences for chambers associated with IP cocaine vs age-matched pups. Unconditioned stimuli were systematically assigned to the least-preferred chamber of separate groups of dams before conditioning. Control dams verified that unconditioned stimuli were necessary for CPP and stimulusassociated locomotion.Results-Compared with most late postpartum dams (60%), only 31% of early postpartum dams preferred the cocaine-associated chamber (P<0.05). Substantially more dams preferred the pupassociated chamber during early postpartum (27%) than late postpartum (5%; P<0.05). Locomotor sensitization emerged across cocaine-conditioning sessions in cocaine-preferring but not puppreferring dams (P<0.05). Locomotor rates were consistently lower in preferred vs nonpreferred chambers during test.Conclusions-After increasing cocaine's incentive salience, more early postpartum dams prefer the cocaine-associated chamber than previously reported (Mattson et al. 2001). However, pupassociated chamber preference was still higher in early vs late postpartum. Pup-and cocainepreferring dams expressed differences in the induction phase of locomotor sensitization across cocaine conditioning but expressed similar motoric patterns in their preferred chambers at test.

show abstract

Section: Conditioned Place Preferencementioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Increasing the incentive salience of cocaine challenges preference for pup- over cocaine-associated stimuli during early postpartum: place preference and locomotor analyses in the lactating female rat

Seip

Morrell

2007

Psychopharmacology

View full text Add to dashboard Cite

show abstract

“…In the mouse, the onset of maternal behavior is not strictly dependent on the high levels of estrogen produced during late pregnancy; nulliparous females demonstrate spontaneous maternal behavior (10)(11)(12)(13)(14), as do ovariectomized and aromatase knockout mice (14,15). However, there is evidence indicating a role for estrogen (14)(15)(16) and demonstrating the importance of ERa in the display of mouse maternal behavior (17,18).…”

mentioning

confidence: 94%

Bisphenol S (BPS) alters maternal behavior and brain in mice exposed during pregnancy/lactation and their daughters

Catanese

Vandenberg

2016

Endocrinology

View full text Add to dashboard Cite

Estrogenic endocrine disrupting chemicals have been shown to disrupt maternal behavior in rodents. We investigated the effects of an emerging xenoestrogen, bisphenol S (BPS), on maternal behavior and brain in CD-1 mice exposed during pregnancy and lactation (F0 generation) and in female offspring exposed during gestation and perinatal development (F1 generation). We observed different effects in F0 and F1 dams for a number of components of maternal behavior, including time on the nest, time spent on nest building, latency to retrieve pups, and latency to retrieve the entire litter. We also characterized expression of estrogen receptor a in the medial preoptic area (MPOA) and quantified tyrosine hydroxylase immunoreactive cells in the ventral tegmental area, 2 brain regions critical for maternal care. BPS-treated females in the F0 generation had a statistically significant increase in estrogen receptor a expression in the caudal subregion of the central MPOA in a dose-dependent manner. In contrast, there were no statistically significant effects of BPS on the MPOA in F1 dams or the ventral tegmental area in either generation. This work demonstrates that BPS affects maternal behavior and brain with outcomes depending on generation, dose, and postpartum period. Many studies examining effects of endocrine disrupting chemicals view the mother as a means by which offspring can be exposed during critical periods of development. Here, we demonstrate that pregnancy and lactation are vulnerable periods for the mother. We also show that developmental BPS exposure alters maternal behavior later in adulthood. Both findings have potential public health implications. (Endocrinology 158: 516-530, 2017)

show abstract

“…Conditioning techniques have been used to help distinguish between motivation and performance for many behaviors including feeding and drinking (Hodos 1961;Skinner 1938), drug taking (Weeks 1964), running (Kagan and Berkun 1954), copulation , maternal behavior (Hauser and Gandelman 1985;Lee et al 1999), as well as aggression (Connor 1974;Fish et al 2002). Such distinctions can be illuminating as in the stimulation of food-reinforced lever pressing by the anorectic drug amphetamine (Gonzalez and Goldberg 1977;Hoebel 1985;Foltin 2001), and the increased responding for access to an infusion of a moderate cocaine dose but overall suppression of cocaine intake by 5-HT 1B agonists (Parsons et al 1998).…”

mentioning

confidence: 99%

5-HT1B receptor inhibition of alcohol-heightened aggression in mice: comparison to drinking and running

et al. 2007

View full text Add to dashboard Cite

These results confirm the inhibitory effects of 5-HT(1B) receptor stimulation on aggressive performance and drinking. They also reveal an inhibition of voluntary wheel running, contrary to the stimulation of running in a novel, open arena. 5-HT(1B) receptor agonists may be particularly useful for the treatment of aggressive behavioral disorders, but their efficacy and potency appear to be sensitive to the intensity and context of the behavior.

show abstract

Lever pressing for pups: Evidence for hormonal influence upon maternal behavior of mice

Cited by 74 publications

References 19 publications

Increasing the incentive salience of cocaine challenges preference for pup- over cocaine-associated stimuli during early postpartum: place preference and locomotor analyses in the lactating female rat

Increasing the incentive salience of cocaine challenges preference for pup- over cocaine-associated stimuli during early postpartum: place preference and locomotor analyses in the lactating female rat

Bisphenol S (BPS) alters maternal behavior and brain in mice exposed during pregnancy/lactation and their daughters

5-HT1B receptor inhibition of alcohol-heightened aggression in mice: comparison to drinking and running

Contact Info

Product

Resources

About