Levonorgestrel Implants Enhanced the Suppression of Spermatogenesis by Testosterone Implants: Comparison between Chinese and Non-Chinese Men

Wang, Christina; Wang, Xin Hai; Nelson, Anita L.; Lee, Ka Kui; Cui, Yu; Tong, Jian; Berman, Nancy; Lumbreras, Leslie; Leung, A. F.; Hull, Laura; Desai, Sumit; Swerdloff, Ronald S.

doi:10.1210/jc.2005-1743

Cited by 46 publications

(27 citation statements)

References 27 publications

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“…Monthly injection of testosterone undecanoate in Chinese men did not cause headaches [9,35,45]. Headache was reported in 5% of men in a short term study using testosterone and Nestorone gel treatment for 20 days [33] however other studies which used combination of testosterone and progestin combinations did not report headache as a side effect [31,44,46,48,59]. Because non-specific headaches are common occurrence in healthy men, the issue whether hormonal contraception has any causal effect on headaches should be demonstrated in placebo controlled studies.…”

Section: Headachementioning

confidence: 99%

“…With the suppression of spermatogenesis, seminiferous tubule volume decreases resulting in reversible decreases in testicular volume [36,37]. Testis volume decreases usually by 4-5 ml [9,34,38]. This decrease in size of the testis is usually not reported by most men participating in contraceptive studies.…”

Section: Testis Volumementioning

confidence: 99%

“…The effect of testosterone on stimulating red cells is not due to increases in erythropoietin but rather simulation of erythropoesis by other mechanisms including suppression of hepcidin [43]. In most contraceptive clinical trials, hemoglobin and hematocrit showed significant increases but rarely are a cause for discontinuation because usually near physiological replacement doses of testosterone were used [6,31,35,[44][45][46][47]. Such increases in hematocrit and hemoglobin was not observed in a few studies [ 48,49] and also when testosterone was administered with an antiandrogen such as cyproterone acetate [50,51].…”

Section: Erythrocytosis Coagulation Factors and Thromboembolismmentioning

confidence: 99%

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Male hormonal contraception: Potential risks and benefits

Ilani

Swerdloff

Wang

2011

Rev Endocr Metab Disord

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An effective, safe, reversible, and acceptable method of contraception is an important component of reproductive health and provides the opportunity of shared responsibility for family planning for both partners. Female hormonal contraceptives have been proven to be safe, reversible, available and widely acceptable by different populations. In contrast, male hormonal contraception, despite significant progress showing contraceptive efficacy comparable to female hormonal methods during last three decades, has not yet led to an approved product. Safety of a pharmaceutical product is an appropriate concern but the majority of male hormonal contraceptive clinical trials have not reported significant short term safety concerns. While the absence of serious adverse effects is encouraging, the studies have been designed for efficacy endpoints not long term safety. In this review we summarize potential risks and benefits of putative male hormonal contraceptives on reproductive and non-reproductive organs. While the review covers what we believe will be the likely class of drugs used for male hormonal contraception a true assessment of long term risks and benefits cannot be achieved without an available product.

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Section: Headachementioning

confidence: 99%

Section: Testis Volumementioning

confidence: 99%

Section: Erythrocytosis Coagulation Factors and Thromboembolismmentioning

confidence: 99%

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Male hormonal contraception: Potential risks and benefits

Ilani

Swerdloff

Wang

2011

Rev Endocr Metab Disord

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“…[53][54][55] In Chinese men, injectable testosterone undecanoate (TU) alone or in combination with oral levonorgestrel (LNG) resulted in the relatively slow suppression of spermatogenesis. 56 Thus, this study provides an ideal model with hormone-induced suppression of spermatogenesis.…”

Section: Hormone-induced Suppression Model Of Spermatogenesismentioning

confidence: 99%

Proteomics of spermatogenesis: from protein lists to understanding the regulation of male fertility and infertility

Huang¹,

Sha²

2010

Asian J Androl

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Proteomic technologies have undergone significant development in recent years, which has led to extensive advances in protein research. Currently, proteomic approaches have been applied to many scientific areas, including basic research, various disease and malignant tumour diagnostics, biomarker discovery and other therapeutic applications. In addition, proteomics-driven research articles examining reproductive biology and medicine are becoming increasingly common. The key challenge for this field is to move from lists of identified proteins to obtaining biological information regarding protein function. The present article reviews the available scientific literature related to spermatogenesis. In addition, this study uses two-dimensional electrophoresis mass spectrometry (2DE-MS) and liquid chromatography (LC)-MS to construct a series of proteome profiles describing spermatogenesis. This large-scale identification of proteins provides a rich resource for elucidating the mechanisms underlying male fertility and infertility.

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“…In addition, there are ethnic differences in the response of sperm concentrations to male contraceptive regimens. For example, study volunteers in Asia exhibit rates of azoospermia in the 90 -100% range on testosterone-alone regimens, whereas Caucasian men have rates of azoospermia closer to 60% with the same treatment (142, [213][214]216). The explanation for this difference is unknown, although it is unlikely to be due to different rates of metabolic clearance of testosterone (122), and it complicates extrapolation of rates of suppression of sperm concentrations between populations.…”

Section: Male Hormonal Contraceptive Methodsmentioning

confidence: 99%