Lichen Planopilaris Treated With a Peroxisome Proliferator–Activated Receptor γ Agonist

Mirmirani, Paradi; Karnik, Pratima

doi:10.1001/archdermatol.2009.283

Cited by 108 publications

(89 citation statements)

References 17 publications

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“…Based on these findings in mice, clinicians have successfully treated refractory lichen planopilaris using pioglitazone hydrochloride. 35 Although this is a potentially important development, confirmatory case reports and clinical trials are needed.…”

Section: Lymphocytic Alopeciamentioning

confidence: 99%

Primary cicatricial alopecia: diagnosis and treatment

Filbrandt

Rufaut

Jones

et al. 2013

CMAJ

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Review CMAJ• Inflammation that destroys the bulge of the outer root sheath destroys the hair follicle and leads to cicatricial alopecia.• Primary cicatricial alopecia is an inflammatory disorder of unknown cause that leads to irreversible hair loss.• The natural history is for the alopecia to extend slowly over the scalp and eventually burn out. The rate of extension and the final severity are extremely variable and difficult to predict.• A number of treatments are used empirically; however, they are not supported by data from clinical trials.

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Section: Lymphocytic Alopeciamentioning

confidence: 99%

Primary cicatricial alopecia: diagnosis and treatment

Filbrandt

Rufaut

Jones

et al. 2013

CMAJ

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“…31 This is especially pertinent given the emerging role of peroxisome proliferator-activator receptor (PPAR)-c in the aetiopathogenesis of scarring alopecias such as LPP. 72,73 Clinically, CCCA presents as a slow-growing area of alopecia involving the crown and/or vertex scalp regions 3,74 (Figs 4b and 7). The involved area appears smooth and shiny, with loss of follicular orifices.…”

Section: Central Centrifugal Cicatricial Alopeciamentioning

confidence: 99%

“…73 The aetiology of FFA remains unknown. Various hypotheses exist including environmental and genetic factors.…”

Section: Lichen Planopilaris and Frontal Fibrosing Alopeciamentioning

confidence: 99%

Hair and scalp disorders in women of African descent: an overview

2013

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“…From the 326 responders, 16 were excluded from analysis because of a history of alopecia areata, lupus, and/or other hair loss pattern that was consistent with either of these types of hair loss. The NAHRS central hair loss scale was used to grade central hair loss in all responders.…”

Section: Demographic Data and Clinical Findingsmentioning

confidence: 99%

Medical and Environmental Risk Factors for the Development of Central Centrifugal Cicatricial Alopecia

Kyei

Bergfeld²,

Piliang³

et al. 2011

Arch Dermatol

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To investigate medical and environmental risk factors for central centrifugal cicatricial alopecia (CCCA), the most common type of scarring alopecia in African American women.Design: A population study involving a quantitative cross-sectional survey of risk factors for CCCA. Survey results are then correlated with a clinical evaluation for CCCA using a standardized, previously published central scalp alopecia photographic scale.Setting: Two African American churches and a health fair for African American women in Cleveland, Ohio.Participants: A total of 326 African American women who participated in the hair study.Main Outcome Measures: Prevalence of CCCA in the general African American population and risk factors associated with CCCA.Results: Of the 326 responders, 28% received a grade of 2 or higher using a standardized, previously pub-lished central scalp alopecia photographic scale, a score consistent with clinically evident central hair loss. Advanced central hair loss with clinical signs of scarring (grade Ն3) was seen in 59% of these respondents and was interpreted as clinically consistent with CCCA. Diabetes mellitus type 2 was significantly higher in those with CCCA (P=.01), as were bacterial scalp infections (P=.045) and hair styles associated with traction (eg, from braids and weaves) (P =.02). Conclusions:Our survey results suggest that there is a high prevalence of central hair loss among African American women. Hair styles causing traction as well as inflammation in the form of bacterial infection may be contributing to the development of CCCA. The increase in diabetes mellitus type 2 among those with CCCA is in line with the recent theory that cicatricial alopecia may be a manifestation of metabolic dysregulation.

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Lichen Planopilaris Treated With a Peroxisome Proliferator–Activated Receptor γ Agonist

Cited by 108 publications

References 17 publications

Primary cicatricial alopecia: diagnosis and treatment

Primary cicatricial alopecia: diagnosis and treatment

Hair and scalp disorders in women of African descent: an overview

Medical and Environmental Risk Factors for the Development of Central Centrifugal Cicatricial Alopecia

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