Lidocain reduziert die Bildung eines Gewebeödemes in der ischämisch- reperfusionsgeschädigten Darmwand des Pferdes

Guschlbauer, M; Slapa, J; Huber, Korinna; Feige, Karsten

doi:10.21836/pem20100406

Cited by 5 publications

(1 citation statement)

References 7 publications

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“…Investigators in 1 study 21 found that lidocaine was able to decrease the release of adenosine, other ATP metabolites, and CK from heart muscle when administered during the hypoxic period, thereby increasing the contractile performance of cardiac muscle. Higher membrane stability of blood vessel endothelial cells was also assessed in a study 22 of morphological changes in IRinjured intestinal wall influenced by lidocaine. In vivo treatment of the distal portion of the jejunum with lidocaine resulted in less edema in all tissue layers, which supported the concept that alterations in membrane permeability could contribute to lidocaine effects.…”

Section: Discussionmentioning

confidence: 99%

Effects of in vivo lidocaine administration at the time of ischemia and reperfusion on in vitro contractility of equine jejunal smooth muscle

Guschlbauer

Feige²,

Geburek³

et al. 2011

ajvr

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Section: Discussionmentioning

confidence: 99%

Effects of in vivo lidocaine administration at the time of ischemia and reperfusion on in vitro contractility of equine jejunal smooth muscle

Guschlbauer

Feige²,

Geburek³

et al. 2011

ajvr

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Suspected lidocaine toxicity and the use of metoclopramide and neostigmine to treat post‐operative small intestinal ileus in a donkey

Loomes¹,

Loomes²

2022

Vet Record Case Reports

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A 17‐year‐old donkey underwent exploratory laparotomy to correct a caecal impaction via typhlotomy in combination with pelvic flexure enterotomy. Intravenous lidocaine (3 mg/kg/h; lidocaine 2% solution, BOVA Specials, London, UK) was administered throughout general anaesthesia following a loading dose (1.3 mg/kg, intravenously [IV]). The donkey recovered uneventfully. One hour after recovery, shortly after returning to the stable and commencement of lidocaine, the donkey showed ataxia, muscle fasciculations and tachycardia with progression to recumbency. Lidocaine toxicity was presumed, so the infusion was stopped and the donkey returned to standing. On Day 2 after surgery, post‐operative reflux was voluminous, so a metoclopramide infusion (0.04 mg/kg/h IV; metoclopramide 5 mg/ml injection, Siegfried Hameln, Hameln, Germany) was commenced. On Day 3, post‐operative reflux persisted, so a neostigmine infusion (0.008 mg/kg/h IV; neostigmine methylsulfate injection 2.5 mg/ml, Siegfried Hameln, Hameln, Germany) was also administered. Small intestinal motility improved by Day 5 and post‐operative reflux resolved by Day 6. Both infusions were stopped and food was re‐introduced. There was no further indication of gastrointestinal hypomotility and the donkey was discharged 11 days later.

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Lidocaine and structure-related mexiletine induce similar contractility-enhancing effects in ischaemia–reperfusion injured equine intestinal smooth muscle in vitro

Tappenbeck¹,

Hoppe²,

Hopster³

et al. 2013

The Veterinary Journal

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Lidocain reduziert die Bildung eines Gewebeödemes in der ischämisch- reperfusionsgeschädigten Darmwand des Pferdes

Cited by 5 publications

References 7 publications

Effects of in vivo lidocaine administration at the time of ischemia and reperfusion on in vitro contractility of equine jejunal smooth muscle

Effects of in vivo lidocaine administration at the time of ischemia and reperfusion on in vitro contractility of equine jejunal smooth muscle

Suspected lidocaine toxicity and the use of metoclopramide and neostigmine to treat post‐operative small intestinal ileus in a donkey

Lidocaine and structure-related mexiletine induce similar contractility-enhancing effects in ischaemia–reperfusion injured equine intestinal smooth muscle in vitro

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