Lidocaine and bupivacaine exert differential effects on whole blood coagulation

Tobias, M; Henry, C.; Augostides, Yianni G.T

doi:10.1016/s0952-8180(98)00132-9

Cited by 22 publications

(19 citation statements)

References 8 publications

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“…The anticoagulatory effects of heparin cause a prolongation of the coagulation time and of the clot formation time, which describe the kinetics of the coagulation process, and make the maximum amplitude as the place of the maximal firmness thinner up to the point of non-measurability of the sample. Besides heparin, many further substances may interfere with ROTEG results, including local anaesthetics or protamine [10][11][12]. Currently, the haemostatic potential of transfused blood products or reinfused autologous blood and their influence on the fibrinolytic system, respectively, have not been systematically evaluated.…”

Section: Principle Of Rotational Thrombelastographymentioning

confidence: 99%

Thrombelastography Today: Practicability and Analytical Power

Hänecke¹,

Klouche²

2007

Transfus Med Hemother

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Today, rotational thrombelastography as a further development of the classical thrombelastography is increasingly applied to assess haemostasis and to predict complications of coagulation. Due to the improved robustness of the method, RoTEM analyses are now also performed outside specialised coagulation laboratories and applied in emergency settings. Since coagulation testing, particularly when performed with different activators, is very sensitive to artifacts due to variations in the proportion to anticoagulants, temperature and concentration of activators, meticulous quality control is indispensable. For this reason, the German Federal Chamber of Physicians has issued rigorous validity ranges for the classic coagulation tests, such as the prothrombin time (PT/INR) or the activated partial thromboplastin time (aPTT) for variation coefficient acceptance, which are audited 4 times a year by external quality control circles. At present, no comparable quality assurance setup exists for whole blood coagulation testing. Thus, knowledge of the analytical limits, restrictions and caveats of this method is central for critical interpretation of the results and reliable clinical application. This review gives an outline of the practicability and accuracy of the RoTEM methodology and illustrates some pitfalls for the use in detecting and predicting disturbances of haemostasis in a case report.

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Section: Principle Of Rotational Thrombelastographymentioning

confidence: 99%

Thrombelastography Today: Practicability and Analytical Power

Hänecke¹,

Klouche²

2007

Transfus Med Hemother

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“…In contrast, Kohrs et al [15] reported that after incubation of whole blood with 2 µm bupivacaine thromboelastography reaction time and coagulation growth time increases significantly and maximal amplitude decreased. In another study it is demonstrated that bupivacaine in concentration of 0.125% and 0.25% significantly impairs coagulation in a concentrationdependent manner by thromboelastography [5] . The authors of this study mentioned that besides the known neuronal action of local anesthetics by blocking membrane ion channels, they may also stabilize the membrane of platelets, inhibiting both alpha-granule release, thromboxane A2 signaling and aggregation [5] .…”

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confidence: 94%

“…The method and the parameters of ROTEM have been described in detail previously by Akay et al [1] . The local anesthetic concentration was prepared to produce a final blood concentrations equal to 0.125% bupivacaine [4,5] . After incubating the test solution at 37° for 2 min, 300 µl citrated blood was re-calcified with 20 µl 0.…”

mentioning

confidence: 99%

Potential Antithrombotic Effects of Bupivacaine in Malignancies: An In Vitro Assesment Using Thromboelastography

Bilir¹,

Akay²,

Ceyhan³

et al. 2016

ijps

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“…However, to induce inhibition of platelet aggregation and coagulation in vitro required concentrations 10-fold to 100-fold greater than those used clinically. [4][5][6] LA modulate excessive inflammatory responses without significantly impairing host defense. 7 Therefore, by analogy, it is conceivable that LA abolish hypercoagulability induced by surgery without affecting physiologic aggregation and coagulation processes.…”

mentioning

confidence: 99%