1989
DOI: 10.1097/00005344-198906000-00012
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Lidocaine Reduces Canine Infarct Size and Decreases Release of a Lipid Peroxidation Product

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Cited by 80 publications
(19 citation statements)
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“…Lidocaine reduced the infarct area and lipid degradation products in the treatment group. Similar to the current study, the study of Lesnefsky et al [23] did not show a decline in neutrophil infiltration. Conforming with those reports, the results of our study suggested that lidocaine inhibited the formation of oxygen radicals and protected the tissue from oxidative injury.…”
Section: Discussionsupporting
confidence: 90%
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“…Lidocaine reduced the infarct area and lipid degradation products in the treatment group. Similar to the current study, the study of Lesnefsky et al [23] did not show a decline in neutrophil infiltration. Conforming with those reports, the results of our study suggested that lidocaine inhibited the formation of oxygen radicals and protected the tissue from oxidative injury.…”
Section: Discussionsupporting
confidence: 90%
“…Lidocaine blocks superoxide anion production, which is a membrane function in neutrophils [22,23]. Lesnefsky et al [23] conducted a study on dogs and performed IR following ligation of left coronary artery, and delivered lidocaine to the treatment group. Lidocaine reduced the infarct area and lipid degradation products in the treatment group.…”
Section: Discussionmentioning
confidence: 99%
“…B. Dauer des Verschlusses). Während einige tierexperimentelle Untersuchungen einen protektiven Effekt von Lidocain auf das ischämische Myokard und eine Reduktion der Infarktgrö-ße zeigten [50,53], fanden andere weder eine signifikante Verminderung der Leukozytenakkumulation im Myokard noch eine Reduktion der Infarktgröße durch Lidocain (Plasmaspiegel ca.4 µg/ml) [56].…”
Section: Einfluss Von Lokalanästhetika Auf Myokardinfarkt Und Reperfuunclassified
“…A lidocaína não foi capaz de diminuir a disfunção ventricular aguda determinada pela agressão isquêmica, apesar da ausência de mortalidade dos animais do grupo I. Resultados discordantes foram obtidos NASSER et al 19 , LEE et al 20 , LESNEFSKY et al 21 e SUNAMORI et al 24 que demonstram redução do dano isquêmico com melhora do desempenho ventricular com a infusão da lidocaína. A avaliação da integridade celular obtida através da análise mitocondrial quantitativa visa a aferição da função metabólica e funcional do miócito.…”
Section: Comentáriosunclassified