Life-threatening megaloblastic pancytopenia with normal mean cell volume: Case series

Sekhar, Jeevan; Stabler, Sally P.

doi:10.1016/j.ejim.2007.02.023

Cited by 11 publications

(7 citation statements)

References 5 publications

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“…15 MCV was found to be normal in 5.3% of the patients which is lower than another study. 14 TS was the commonest biopsy diagnosis in the study accounting for 49.5% of patients diagnosed as having megaloblastic anemia, which is similar to most other studies. 16,17 Endoscopic finding of scalloped duodenal folds was identified in 32.6% of TS.…”

Section: Discussionsupporting

confidence: 88%

The Value of Duodenal Biopsies in the Evaluation of Megaloblastic Anemia

2021

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Introduction Megaloblastic anemia is one of the common causes of anemia in India. Duodenal biopsies are routinely performed in the investigation of megaloblastic anemia. The present study was undertaken to analyze the value of duodenal biopsy in megaloblastic anemia and to correlate endoscopic findings with biopsy. As a secondary aim, the study has also analyzed the hematological profile and vitamin B12 and folate status of these patients. Materials and methods All the cases of megaloblastic anemia with bone marrow studies diagnosed at PSG Institute of Medical Sciences and Research during the two year period from January 2016 to December 2017 were retrieved. Clinical and laboratory findings (serum vitamin B12 and folate levels) and endoscopic findings were retrieved from hospital records of the patients. Duodenal biopsies of these patients reported in the histopathology department were retrieved and reviewed. Statistical analysis was done using SPSS software 20.0. Results There were 93 cases of megaloblastic anemia diagnosed on bone marrow biopsies. Tropical sprue was diagnosed in 49.5% of cases, followed by intraepithelial lymphocytosis (17.2%), peptic duodenitis (17.2%), and no significant pathology in 16% of cases. Pancytopenia was present in 54.8% of cases. Isolated vitamin B12 deficiency including low levels was present in 48.38% and folate deficiency was seen in 4.3% cases; 34.48% cases had both vitamin B12 and folate deficiency. Conclusion The incidence of tropical sprue in megaloblastic anemia is 49.5% in the study. Duodenal biopsy is valuable in the work up of megaloblastic anemia, irrespective of the endoscopic changes in identifying the etiology.

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Section: Discussionsupporting

confidence: 88%

The Value of Duodenal Biopsies in the Evaluation of Megaloblastic Anemia

2021

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“…For childbirth method and termination of pregnancy, Klein from Germany reported nine out of sixteen cases of gestational thrombocytopenia to have natural childbirth and five to have cesarean delivery. Sekhar reported six out of eight cases of gestational thrombocytopenia to have natural childbirth and two to have cesarean delivery [17]. In our case, the childbirth was natural.…”

Section: Discussionsupporting

confidence: 50%

“…In the case reported by Suarez (1951), only purpura and splenomegaly were observed and the patient was hospitalized with suspected aplastic anemia or allochemia and was diagnosed with megaloblastic anemia by bone marrow biopsy [10]. Sekhar reported three cases of pernicious anemia in non-pregnant women with normal MCV and different symptoms of dyspnea and hemoptysis, diabetes, gastritis, hepatitis C, ataxia, and numbness in the extremities, syncope or skin rashes diagnosed with severe vitamin B12 deficiency, bone marrow and pancytopenia [17]. Others have also reported megaloblastic anemia associated with other diseases in non-pregnant women [18]; megaloblastic anemia is not studied in pregnant women perhaps because of its rare prevalence.…”

Section: Discussionmentioning

confidence: 99%

A Case of Megaloblastic Anemia with Thrombocytopenia

Moghadam¹,

Gholami²

2016

OJOG

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Megaloblastic anemias are a group of hematologic disorders in which abnormal DNA synthesis causes blood and bone marrow disorders. This type of anemias occurs as a result of folic acid deficiency or impaired vitamin B12 absorption. The prevalence of this type of anemia is highly variable worldwide and megaloblastic anemia caused by lack of vitamin B12 (cyanocobalamin) is rare during pregnancy [1]. In this case report, we report follow-ups conducted for a pregnant 33-yearold woman, G2, P1, with a history of previous natural childbirth who attended Kamali Hospital due to labor pain associated with severe thrombocytopenia. Although this woman was injected 10 units of PLT and also vitamin B12 (cyanocobalamin), folic acid and corticosteroids in the course of treatment, her platelet level has not yet returned to normal levels after 6 months and she is still being treated.

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“…[12] Anisocytosis and poikilocytosis is higher in megaloblastic anemia. [16,19] We observed anisopoikilocytosis in most of cases in present study.…”

Section: Table3 Distribution Of Cases According To Age Group In Macrosupporting

confidence: 56%

Clinicopathological profile of anaemia cases in adults (20-60 years) attending a rural hospital

Pandure

Ghosh²

2017

AABS

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Background: Anemia is a worldwide problem with highest incidence in developing countries. India has the highest prevalence of nutritional anemia predominantly in women and children.Methods: An observational and analytical study was carried out for period of 12 months. We studied 261 adult patient for typing the anemia. We perform the hematology parameter by automated hematologyanalyzer,For confirmation PBS and bone marrow examination, serological test like serum iron profile , vit B12 and folic acid levels in blood is done Result: Total 261 cases of anemia included in the study. Microcytic hypochromic anemia were63.2 %of cases, macrocytic anemia cases were 36.77% of cases. Large number of iron deficiency anemia's were seen in female with reproductive age group and megaloblastic anemia seen with age 50-60 years of age in both sex. Conclusion:For the diagnosis of nutritional anemia haemogram by automated hematology parameter, PBS, serum iron profile , serum vit B12 and folic acid is required

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Life-threatening megaloblastic pancytopenia with normal mean cell volume: Case series

Cited by 11 publications

References 5 publications

The Value of Duodenal Biopsies in the Evaluation of Megaloblastic Anemia

The Value of Duodenal Biopsies in the Evaluation of Megaloblastic Anemia

A Case of Megaloblastic Anemia with Thrombocytopenia

Clinicopathological profile of anaemia cases in adults (20-60 years) attending a rural hospital

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