Lifestyle and family history influence cancer prognosis in Brazilian individuals

Abstract

The aim of this research was to study prognostic parameters of CRC by analyzing clinical and pathological variables associated with cancer patients at a northeastern Brazilian Hospital. This was a retrospective study evaluating CRC-diagnosed patients across a 10-year period (1995-2005) at Dr. Luiz Antônio Hospital in Natal, RN, Brazil. Data were collected from patients' medical files. A total of 358 patients were included over the 10-year period. The average age at diagnosis was 58.8 years (S.D.=15.26), 48.3% of the patients were males and 51.7% were females. Alcohol consumption significantly increased the chance of dying (p<0.023) from colorectal cancer; this increased risk of death was approximately 71%, compared to 52.2% of the non-alcoholics. In addition, tobacco increased the chance of developing high TNM stage tumors (level III, IV; p<0.001). Another risk factor for increased mortality was a family history for colorectal cancer (p<0.002). Our analysis found that patients with an unhealthy lifestyle and/or family history of colorectal cancer were more likely to develop advanced stage colorectal cancer and to have a poor disease prognosis compared to patients with healthy lifestyle and/or sporadic colorectal cancer. These data suggest that a mass screening program should be implemented in northeastern Brazil in order to better prevent and treat colorectal cancer.

Neurokinin-2 receptor polymorphism predicts lymph node metastasis in colorectal cancer patients

“…In the present study, patients exposed to tobacco exhibited significantly more positive lymph nodes than those patients not exposed to tobacco; this result is consistent with the finding that tobacco exposure has a detrimental effect on CRC (20). In agreement with a previously published study (21), the present study also found that diagnostic stage was associated with the number of metastatic lymph nodes.…”

Impacto Da Distribuição De Número Desigual De Progênies Por Reprodutor Na Avaliação Genética De Animais, Em Ambientes Com Presença De Heterogeneidade De Variância Ambiental

“…Os valores de componentes de variância utilizados neste estudo foram baseados em Araújo et al (7) . Para simulação dos dados, foi utilizado o programa SAS (9) , utilizando-se o PROC INBREED para o cálculo da matriz de parentesco integrado no mesmo algoritmo ao modulo IML, sobre o qual foi realizada toda a simulação de dados anteriormente descrita.…”

“…Com informações de lactações em bubalinos, Araújo et al (7) verificaram médias e componentes de variância maiores para o nível de alta produção, porém com estimativas de herdabilidade menores e correlação genética entre os níveis de 0,58, caracterizando a presença de heterogeneidade de variância entre os rebanhos.…”

Alcohol intake and mortality among survivors of colorectal cancer: The Cancer Prevention Study II Nutrition Cohort

“…It is interesting to note that the majority of the previous studies examined prediagnosis or lifetime alcohol consumption, whereas only one study examined postdiagnosis alcohol consumption, which is more immediately translatable to cancer survivors but also may be more prone to bias. Furthermore, 3 studies included individuals with metastatic colorectal cancer, which may bias the study results because those patients are more likely to die during study follow‐up and are less likely to consume alcohol due to the severity of their disease.…”

“…6 To the best of our knowledge, whether alcohol intake has an impact on mortality among survivors of colorectal cancer is not clear. Nine cohort studies have examined alcohol consumption in relation to long-term, all-cause mortality after colorectal cancer diagnosis, [7][8][9][10][11][12][13][14][15] but only 4 of these studies examined colorectal cancer-specific mortality. 9,10,12,13 Findings from these 9 studies were inconsistent: some studies suggested that light/moderate alcohol consumption compared with no alcohol consumption may be associated with lower all-cause or colorectal cancer-specific mortality, 9,12,13 whereas other studies reported largely null results 8,11 or lower mortality only with red wine consumption.…”