Lifestyle Modifications and Nutritional Interventions in Aging-Associated Cognitive Decline and Alzheimer’s Disease

Bhatti, Gurjit Kaur; Reddy, Arubala P.; Reddy, P. Hemachandra; Bhatti, Jasvinder Singh

doi:10.3389/fnagi.2019.00369

Cited by 100 publications

(72 citation statements)

References 205 publications

(207 reference statements)

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“…The evidence is mounting that the environment has an essential role in the development of neurodegenerative diseases. It is now known that unhealthy lifestyles (including the excessive ingestion of food) combined or otherwise with specific predisposing genes are responsible for most cases of sporadic forms of AD and greatly contribute to sporadic forms of PD ( Bhatti et al, 2020 ; Popa-Wagner et al, 2020 ). However, the classic models of neurodegenerative diseases, based on genetic alterations, do not encompass all the characteristics of these complex diseases ( Ransohoff, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Animal Models of Metabolic Disorders in the Study of Neurodegenerative Diseases: An Overview

Krolow

Farias

et al. 2021

Front. Neurosci.

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The incidence of metabolic disorders, as well as of neurodegenerative diseases—mainly the sporadic forms of Alzheimer’s and Parkinson’s disease—are increasing worldwide. Notably, obesity, diabetes, and hypercholesterolemia have been indicated as early risk factors for sporadic forms of Alzheimer’s and Parkinson’s disease. These conditions share a range of molecular and cellular features, including protein aggregation, oxidative stress, neuroinflammation, and blood-brain barrier dysfunction, all of which contribute to neuronal death and cognitive impairment. Rodent models of obesity, diabetes, and hypercholesterolemia exhibit all the hallmarks of these degenerative diseases, and represent an interesting approach to the study of the phenotypic features and pathogenic mechanisms of neurodegenerative disorders. We review the main pathological aspects of Alzheimer’s and Parkinson’s disease as summarized in rodent models of obesity, diabetes, and hypercholesterolemia.

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Section: Introductionmentioning

confidence: 99%

Animal Models of Metabolic Disorders in the Study of Neurodegenerative Diseases: An Overview

Krolow

Farias

et al. 2021

Front. Neurosci.

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“…There are differences in clinical presentation and pathogenesis of mood disorders in older adults and nutritional neuroscience is an emerging branch indicating that nutrition is related to cognition, behavior, and emotions [ 18 ]. Therefore, diet may have clinical implications and is important for the effective treatment of mood disorders in the elderly.…”

Section: Discussionmentioning

confidence: 99%

Tryptophan Intake and Metabolism in Older Adults with Mood Disorders

et al. 2020

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The role of serotonin in the pathogenesis of depression is well-documented, while the involvement of other tryptophan (TRP) metabolites generated in the kynurenine pathway is less known. The aim of this study was to assess the intake and metabolism of TRP in elderly patients with mood disorders. Ninety subjects in three groups, 30 subjects each, were enrolled in this study: controls (healthy young adults, group I) and elderly individuals without (group II) or with (group III) symptoms of mild and moderate depression, as assessed by the Hamilton Depression Rating Scale (HAM-D) and further referred to as mood disorders. The average TRP intake was evaluated with the nutrition calculator. Urinary levels of TRP, 5-hydroxyindoleacetic acid (5-HIAA), L-kynurenine (KYN), kynurenic acid (KynA), xanthurenic acid (XA), and quinolinic acid (QA) were determined by liquid chromatography with tandem mass spectrometry and related to creatinine level. The average daily intake of TRP was significantly lower in group III than the remaining two groups, but group III was also characterized by higher urinary levels of KYN, KynA, XA, and QA as compared with younger adult individuals and elderly patients without mood disorders. Therefore, mild and moderate depression in the elderly may be associated with a lower intake of TRP and changes in its kynurenine metabolic pathway, which suggests a potential dietary TRP-based intervention in this group of patients.

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“…From current trends demographically, a significant rise in older people above 65 years of age in the world's population poses a significant risk of developing dementia [33]. Consumption of DHA food products has been shown from various studies to decrease neurodegeneration in dementia [15].…”

Section: Nutrition In Dementia and Multiple Sclerosismentioning

confidence: 99%