Lifetime Prevalence of Major Depression and Its Effect on Treatment Outcome in Obese Type II Diabetic Patients

Marcus, Marsha D.; Wing, Rena R.; Guare, John; Blair, Elaine H.; Jawad, Abbas F.

doi:10.2337/diacare.15.2.253

Cited by 101 publications

(61 citation statements)

References 5 publications

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“…On the SCID-IV, we did not find a higher level of general psychiatric psychopathology among BED. This finding, based on a small number of BED subjects, was contrary to that of other investigators such as Marcus et al, 25 or Mussell et al 26 Wilfley and colleagues 10 did not find Axis I psychopathology to be significantly related to baseline eating disturbance in BED, although Axis II psychopathology was significantly related to more frequent binge eating and greater eating psychopathology; unfortunately we did not study Axis II psychopathology in our sample of subjects. The high prevalence of depression in both BED and NBE is consistent with previous findings of a high lifetime prevalence of major depressive disorder in the extremely obese (29 -51%).…”

Section: Discussioncontrasting

confidence: 56%

Binge eating disorder in extreme obesity

et al. 2002

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Section: Discussioncontrasting

confidence: 56%

Binge eating disorder in extreme obesity

et al. 2002

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“…A growing body of literature has established a strong association between depression and type 2 diabetes (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Although the published studies base their conclusions on relatively small sample sizes, the consistency of the relation leaves little doubt that depression and diabetes are closely linked.…”

mentioning

confidence: 83%

Unadjusted and Adjusted Prevalence of Diagnosed Depression in Type 2 Diabetes

2003

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OBJECTIVE -To estimate the prevalence of diagnosed depression in a large population of individuals with type 2 diabetes, compared to a matched control group, and to estimate the extent of depression that is independently associated with diabetes. RESEARCH DESIGN AND METHODS-We compared the prevalence of diagnosed depression in all 16,180 full-year health maintenance organization members in 1999 who had been diagnosed with type 2 diabetes and in 16,180 comparison members without diabetes matched for age and sex. We ascertained diagnoses from the Kaiser Permanente Northwest Region's electronic medical record. Using multiple logistic regression, we adjusted the prevalence estimates for the presence of cardiovascular disease, age, sex, and body weight.RESULTS -Depression was more common in individuals with type 2 diabetes than among matched control subjects (17.9 vs. 11.2%; P Ͻ 0.001). Women in both groups were nearly twice as likely to be depressed as men; however, the relative difference in depression prevalence between subjects with and without diabetes was greater in men. In the multivariate model for women, body weight was a much stronger predictor of depression than diabetes status.CONCLUSIONS -This study further documents the association between depression and diabetes, providing unadjusted population-based estimates in a large sample. Depression remained associated with diabetes after adjustment for several other possible causes. The association among diabetes, cardiovascular disease, depression, and obesity are multifaceted and differ for men and women. Diabetes Care 26:744 -749, 2003

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“…First, depressed individuals are less likely to be compliant with dietary and weight loss recommendations (7) and are more likely to be physically inactive and nonadherent with medications (3)(4)(5)(6). This can lead to worsening of obesity and insulin resistance, increasing the risk of developing type 2 diabetes.…”

Section: Multivariate Analyses Of Depressive Symptomsmentioning

confidence: 99%

Depressive Symptoms and the Risk of Type 2 Diabetes

et al. 2004

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OBJECTIVE -The goal of this study was to determine whether depressive symptoms predict type 2 diabetes. RESEARCH DESIGN AND METHODS-We analyzed data on depressive symptoms (including recent fatigue, sleep disturbance, feelings of hopelessness, loss of libido, and increased irritability) in a longitudinal, biracial cohort study of 11,615 initially nondiabetic adults aged 48 -67 years, who were subsequently followed for 6 years for the development of type 2 diabetes.RESULTS -At baseline, depressive symptoms were positively associated with BMI, fasting insulin, systolic blood pressure, caloric intake, physical inactivity, and current smoking (all P Ͻ 0.05). In prospective analyses, after adjusting for age, race, sex, and education, individuals in the highest quartile of depressive symptoms had a 63% increased risk of developing diabetes compared with those in the lowest quartile (relative hazard [RH] 1.63, 95% CI 1.31-2.02). This relation persisted after adjustment for stress-associated lifestyle factors (smoking, physical activity, caloric intake, and adiposity) (1.28, 1.02-1.60) and metabolic covariates (fasting insulin and glucose, lipids, blood pressure, and adiposity) (1.38, 1.10 -1.73).CONCLUSIONS -In this cohort, depressive symptoms predicted incident type 2 diabetes. This relation is only partially explained by demographic, metabolic, and lifestyle factors. Possible neuroendocrine mediators of the stress-obesity-diabetes relationship require further evaluation in prospective cohort studies that use an established tool to assess depression and incorporate neurohormonal measurements. Diabetes Care 27:429 -435, 2004T here has been a growing interest in depression as a novel risk factor for the development of type 2 diabetes as several studies have demonstrated that the presence of depressive symptoms is predictive of incident type 2 diabetes (1,2). Possible mechanisms include the influence of depressive symptoms on behaviors, such as physical activity, diet, and adherence to treatment recommendations (3-7), or their influence on the activity of the hypothalamic-pituitaryadrenal (HPA) axis and sympathetic nervous system (8 -13). Similar mechanisms have been proposed for parallel observations regarding depressive symptoms as predictors of coronary heart disease (14). Previous epidemiological studies of psychological risk factors as predictors of diabetes, however, have been limited by small sample sizes, limited physiological data, and reliance on self-report of diabetes measures (1,2).The Atherosclerosis Risk in Communities (ARIC) study is an attractive study in which to evaluate this relationship because data from standardized measurements are available on clinical outcomes, such as type 2 diabetes, and on depressive symptoms (as captured by a Vital Exhaustion Questionnaire) in a large, biracial, community-based cohort of middle-aged adults who were followed over a 6-year period. Therefore, we conducted a prospective analysis of depressive symptoms as predictors of type 2 diabetes in middleaged adults in ARIC....

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Lifetime Prevalence of Major Depression and Its Effect on Treatment Outcome in Obese Type II Diabetic Patients

Cited by 101 publications

References 5 publications

Binge eating disorder in extreme obesity

Binge eating disorder in extreme obesity

Unadjusted and Adjusted Prevalence of Diagnosed Depression in Type 2 Diabetes

Depressive Symptoms and the Risk of Type 2 Diabetes

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