Light-activated extracellular matrix microcarriers with engineered MSCs loading for autoimmune psoriasis treatment

Lin, Xiang; Cai, Lijun; Nie, Min; Wu, Xiangyi; Liang, Guozheng; Shang, Luoran; Zhao, Yuanjin

doi:10.1016/j.cej.2023.144118

Chemical Engineering Journal

2023

DOI: 10.1016/j.cej.2023.144118

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Light-activated extracellular matrix microcarriers with engineered MSCs loading for autoimmune psoriasis treatment

Xiang Lin

Lijun Cai

Min Nie

et al.

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Cited by 6 publications

References 34 publications

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Magnetic Polymer Microcarriers for Cell Engineering Applications with Enzyme‐Free Cell Harvesting and Rapid Recovery in Large‐Scale Cell Culture

Liu,

Meng,

Yang

et al. 2023

Adv Funct Materials

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Stimulus‐responsive large‐scale cell culture microcarriers are promising biological materials for large‐scale cell production. Herein, multifunctional thermal and magnetic microcarriers (TMMs) made of poly(N‐isopropylacrylamide) (PNIPAM), polylysines (PLLs), gelatin methacryloyl (GelMA), poly(ethylene glycol) diacrylate (PEGDA), N,N‐methylenebis(acrylamide) (MBA), Fe3O4 and SiO2 are prepared to achieve large‐scale enzyme‐free cell harvesting and also can be used as cells stereogrowth scaffold to mimic cells suspension state to develop novel application, such as recombinant proteins produced. In TMMs, NIPAM and other materials are mixed and then underwent in situ radical polymerization by UV irradition with 2‐hydroxy‐2‐methylpropiophenone as initiator, in which GelMA provides cell adhesion sites and PLLs enable a positive microenvironment with SiO2 as filler. As enzyme‐free cell microcarriers, cell harvesting from TMMs by PNIPAM are achieved at 25 °C through vortex oscillation within 15 min and TMMs can be recycled at least for four times by magnetic recovery. Moreover, TMMs can be used as stereoculture scaffold to let cells in suspension as adherent state to improve gene transfection efficiency. Combined with magnetothermal effect, TMMs can further improve gene transfer to obtain industrialization of proteins expression. Therefore, TMMs are potential for the development of cell manufacturing and the expansion of cell stereogrowth application for recombinant proteins production.

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Magnetic Polymer Microcarriers for Cell Engineering Applications with Enzyme‐Free Cell Harvesting and Rapid Recovery in Large‐Scale Cell Culture

Liu,

Meng,

Yang

et al. 2023

Adv Funct Materials

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show abstract

Synergistic chemo-photodynamic therapy based on hollow mesoporous organosilica nanoparticles for reducing psoriasis-like inflammation

Fan,

Zhao,

Gan

et al. 2024

Chemical Engineering Journal

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Spatiotemporal delivery of microenvironment responsive hydrogel incorporated with stem cells-loaded porous microspheres for abdominal wall repair

Yang,

Wei,

Tao

et al. 2024

Chemical Engineering Journal

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Light-activated extracellular matrix microcarriers with engineered MSCs loading for autoimmune psoriasis treatment

Cited by 6 publications

References 34 publications

Magnetic Polymer Microcarriers for Cell Engineering Applications with Enzyme‐Free Cell Harvesting and Rapid Recovery in Large‐Scale Cell Culture

Magnetic Polymer Microcarriers for Cell Engineering Applications with Enzyme‐Free Cell Harvesting and Rapid Recovery in Large‐Scale Cell Culture

Synergistic chemo-photodynamic therapy based on hollow mesoporous organosilica nanoparticles for reducing psoriasis-like inflammation

Spatiotemporal delivery of microenvironment responsive hydrogel incorporated with stem cells-loaded porous microspheres for abdominal wall repair

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