Light-activated hybrid organic/inorganic antimicrobial coatings

Akarsu, Esin; Uslu, Ramazan

doi:10.1007/s10971-018-4714-y

Cited by 10 publications

(11 citation statements)

References 46 publications

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“…Very good results have been obtained by applying these antimicrobial and antiadhesive coatings on the medical supplies surfaces or on constructed surfaces that can be contaminated with pathogens [18]. There are four main strategies for obtaining antimicrobial surfaces: (i) the release of antimicrobial agents (depending on leaching of incorporated antimicrobial agents); (ii) mechanical damage of the membrane of the pathogens by contact (the cell membranes are disrupted by the contact with immobilized compounds); (iii) use of low-energy surfaces to inhibit the microbial adherence and biofilm development to the surface (immobilization of molecules such as polyethylene glycol and zwitterion that can inhibit cell wall protein adsorption); (iv) use of light-activated coatings (generation of the reactive oxygen species (ROS) such as singlet oxygen and hydroxyl radicals by photosensitizers that can degrade microbial pathogens, causing damage to their DNA or to cell membrane) [19].…”

Section: Introductionmentioning

confidence: 99%

Preliminary Study on Light-Activated Antimicrobial Agents as Photocatalytic Method for Protection of Surfaces with Increased Risk of Infections

et al. 2021

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Preventing and controlling the spread of multidrug-resistant (MDR) bacteria implicated in healthcare-associated infections is the greatest challenge of the health systems. In recent decades, research has shown the need for passive antibacterial protection of surfaces in order to reduce the microbial load and microbial biofilm development, frequently associated with transmission of infections. The aim of the present study is to analyze the efficiency of photocatalytic antimicrobial protection methods of surfaces using the new photocatalytic paint activated by light in the visible spectrum. The new composition is characterized by a wide range of analytical methods, such as UV-VIS spectroscopy, electron microscopy (SEM), X-ray powder diffraction (PXRD) or X-ray photoelectron spectroscopy (XPS). The photocatalytic activity in the UV-A was compared with the one in the visible light spectrum using an internal method developed on the basis of DIN 52980: 2008-10 standard and ISO 10678—2010 standard. Migration of metal ions in the composition was tested based on SR EN1186-3: 2003 standard. The new photocatalytic antimicrobial method uses a type of photocatalytic paint that is active in the visible spectral range and generates reactive oxygen species with inhibitory effect against all tested microbial strains.

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Section: Introductionmentioning

confidence: 99%

Preliminary Study on Light-Activated Antimicrobial Agents as Photocatalytic Method for Protection of Surfaces with Increased Risk of Infections

et al. 2021

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“…This can be achieved by overlapping the absorption spectrum of the photosensitizer with the emission spectrum of the light source. Figure 6 shows the absorption spectrum of Rose Bengal and the emission spectrum of a standard fluorescence lamp used to activate this photosensitizer embedded in an antimicrobial coating [ 293 ]. Knowing the total fluence rate in mW/cm 2 emitted by the lamp, it is possible to calculate the correction factor for the number of photons emitted by the lamp actually absorbed by the photosensitizer, by comparison with the photons absorbed when an ideal monochromatic light source emits at the lowest-energy peak of the photosensitizer absorption spectrum [ 291 ].…”

Section: Light Sources For Pddimentioning

confidence: 99%

“…An even more general example is the use of PDDI in environmental disinfection using a antimicrobial coating of Rose Bengal, which actually corresponds to the system illustrated in Fig. 6 [ 293 ]. There are vast opportunities to develop combinations of devices with photosensitizers in medical, veterinary, agricultural, food safety and environmental fields.…”

Section: Light Sources For Pddimentioning

confidence: 99%

Photodynamic disinfection and its role in controlling infectious diseases

Aroso

Schaberle

Arnaut

et al. 2021

Photochem Photobiol Sci

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Photodynamic therapy is witnessing a revival of its origins as a response to the rise of multi-drug resistant infections and the shortage of new classes of antibiotics. Photodynamic disinfection (PDDI) of microorganisms is making progresses in preclinical models and in clinical cases, and the perception of its role in the clinical armamentarium for the management of infectious diseases is changing. We review the positioning of PDDI from the perspective of its ability to respond to clinical needs. Emphasis is placed on the pipeline of photosensitizers that proved effective to inactivate biofilms, showed efficacy in animal models of infectious diseases or reached clinical trials. Novel opportunities resulting from the COVID-19 pandemic are briefly discussed. The molecular features of promising photosensitizers are emphasized and contrasted with those of photosensitizers used in the treatment of solid tumors. The development of photosensitizers has been accompanied by the fabrication of a variety of affordable and customizable light sources. We critically discuss the combination between photosensitizer and light source properties that may leverage PDDI and expand its applications to wider markets. The success of PDDI in the management of infectious diseases will ultimately depend on the efficacy of photosensitizers, affordability of the light sources, simplicity of the procedures, and availability of fast and efficient treatments. Graphic abstract

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“…All the tests satisfied the requirements for validity specified in JIS R 1752. Log reduction (11) was used to quantify the living microbes. Using a logarithmic scale, the ratio of the number of viable colonies after irradiation with the photosensitizer to the number of viable colonies in the control study (without PS) under the same treatment conditions was calculated.…”

Section: Generation Of 1 O 2 In the Rc Film By Irradiation With Visible Lightmentioning

confidence: 99%

“…In contrast to antibiotics, the mechanism by which species derived from reactions with 1 O 2 kill bacteria is completely unselective, and offers little room for evolutionary adaptation (5). To reduce the demands imposed by the continuous disinfection of environmental surfaces, films or structures containing photosensitizers (PSs)which can generate 1 O 2 when irradiated with visible light under aerobic conditions-have attracted considerable attention because they have the potential for continuous self-disinfection in everyday environments (6)(7)(8)(9)(10)(11). A photoexcited PS can follow one of two reaction pathways called Type I and Type II.…”

Section: Introductionmentioning

confidence: 99%

Penetration of Singlet Oxygen into Films with Oxygen Permeability Coefficient Close to that of Skin

Harada

Kataoka

Nakanosho

et al. 2021

Photochem & Photobiology

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Although its antiviral and antibacterial functions help prevent infection, singlet oxygen ( 1 O 2 )-which is generated by the action of light on an endogenous photosensitizer-is cytotoxic. In the present study, we investigated the ability of 1 O 2 -generated by the action of visible light on a photosensitizer-to penetrate skin. We used two polymer films with oxygen permeability coefficients similar to that of skin-i.e. cellulose acetate (CA) and ethyl cellulose (EC). Both films contained 1,3-diphenylisobenzofuran (DPBF), which was used as an 1 O 2 probe. 1 O 2 generated externally did not permeate the films by mere contact. Therefore, we conclude that the potential for 1 O 2 to penetrate the skin is very low, and films that generate 1 O 2 are safe and useful for preventing infections by contact. We also proved that 1 O 2 can move between the layers of integrated polymer films when they are joined together.

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Light-activated hybrid organic/inorganic antimicrobial coatings

Cited by 10 publications

References 46 publications

Preliminary Study on Light-Activated Antimicrobial Agents as Photocatalytic Method for Protection of Surfaces with Increased Risk of Infections

Preliminary Study on Light-Activated Antimicrobial Agents as Photocatalytic Method for Protection of Surfaces with Increased Risk of Infections

Photodynamic disinfection and its role in controlling infectious diseases

Penetration of Singlet Oxygen into Films with Oxygen Permeability Coefficient Close to that of Skin

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