Abstract:The absorption and emission of light by biological systems is a dilemma for the research community which remains transfixed upon the bottom-up systems biology approach. Many health care professionals do not yet accept that photosensitivity is an essential aspect of the body's function.This article highlights that light is often required to activate enzymes and/or proteins in biological systems. Inadequate levels of exposure to light may be responsible, at least in part, for the uncoiled nature of proteins found in diabetes mellitus, Alzheimer's disease, and other conditions. Moreover the emission of light, the consequence of protein reactions with reactive substrates or of reactive oxygen species, is an often observed characteristic of pathologies and influences the visual perception of colour. It illustrates that a significant diagnostic principle exists by measuring the levels of light absorbed and/or the bioluminescence released from fluorescent pathologies.