This paper presents a multi-sensing pixel capable of sensing ion concentration, temperature, moisture and light from the same spatial point. The presented pixel is composed of an ISFET chemical sensor, a light sensor, a moisture sensor and a temperature sensor, all implemented in standard CMOS technology in a compact pixel. All sensing modalities are acquired simultaneously and modulated onto a single waveform using multi-frequency PWM modulation, overcoming the associated transmission overhead. Furthermore, ISFET non-idealities such as trapped charge are compensated through a global DAC, balancing the input linear OTA, while the light sensor dark current is mitigated in-pixel by subtracting its influence using a reference photodiode. The proposed pixel occupies 50x50 µm 2 , and it is integrated as part of a 4x4 multi-sensing array, along with on-chip biasing, instrumentation and digital control. To the best of our knowledge, this architecture represents the first multisensing architecture capable of extracting four features from the same spatial point simultaneously, enabling ISFET-based platforms to sense both the chemical signal and the external conditions influencing its measurement.