Light‐Induced Chiral Iron Copper Selenide Nanoparticles Prevent β‐Amyloidopathy In Vivo

Zhang, Hongyu; Hao, Changlong; Qu, Aihua; Sun, Maozhong; Xu, Liguang; Xu, Chuanlai

doi:10.1002/ange.202002028

Cited by 14 publications

(4 citation statements)

References 62 publications

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“…NIR illumination of NPs modified with d‐Pen have the ability to reduce the neurotoxicity of A β 42 fibbers (Figure 44b). [ 373 ] Misfolding and aggregation of alpha‐synuclein ( α ‐syn) is closely associated with Parkinson's disease (PD). Figure 44c shows chiral manganese trioxide (Mn 2 O 3 ) nanoparticles (NPs) for enhanced PD treatment by non‐invasive electromagnetic fields (MF).…”

Section: Application Of Chiral Materialsmentioning

confidence: 99%

“…Reproduced with permission. [ 373 ] Copyright 2020, Wiley‐VCH. c) Schematic illustration of the treatment with chiral NPs for PD mice under MF, T1‐weighted MR images of Mn 2 O 3 NPs from a 3.0 T clinical MRI system.…”

Section: Application Of Chiral Materialsmentioning

confidence: 99%

“…b) Synthetic penicillamine-modified Fe x Cu 𝛾 Se nanoparticles alleviate potential neurotoxicity in a mouse model of AD with A𝛽42 concentrations in cerebrospinal fluid after 60 days of treatment. Reproduced with permission [373]. Copyright 2020, Wiley-VCH.…”

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confidence: 99%

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Chiral Materials: Progress, Applications, and Prospects

Niu

Zhao

Yan

et al. 2023

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Chirality is a universal phenomenon in molecular and biological systems, denoting an asymmetric configurational property where an object cannot be superimposed onto its mirror image by any kind of translation or rotation, which is ubiquitous on the scale from neutrinos to spiral galaxies. Chirality plays a very important role in the life system. Many biological molecules in the life body show chirality, such as the “codebook” of the earth's biological diversity‐DNA, nucleic acid, etc. Intriguingly, living organisms hierarchically consist of homochiral building blocks, for example, l‐amino acids and d‐sugars with unknown reason. When molecules with chirality interact with these chiral factors, only one conformation favors the positive development of life, that is, the chiral host environment can only selectively interact with chiral molecules of one of the conformations. The differences in chiral interactions are often manifested by chiral recognition, mutual matching, and interactions with chiral molecules, which means that the stereoselectivity of chiral molecules can produce changes in pharmacodynamics and pathology. Here, the latest investigations are summarized including the construction and applications of chiral materials based on natural small molecules as chiral source, natural biomacromolecules as chiral sources, and the material synthesized by design as a chiral source.

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Section: Application Of Chiral Materialsmentioning

confidence: 99%

Section: Application Of Chiral Materialsmentioning

confidence: 99%

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Chiral Materials: Progress, Applications, and Prospects

Niu

Zhao

Yan

et al. 2023

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“…[ 8 ] Further interaction between them could effectively regulate the misfolding and abnormal proteins during metabolism by CPL induction. [ 9 ] The key requirement for this action is the control of chiral morphology through ligands.…”

Section: Chiral Nanoprobe Construction and Their Biological Effectsmentioning

confidence: 99%

Chiral Nanoprobes and Their Biological Effects

Sun

Hao

et al. 2020

Chin. J. Chem.

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What is the most favorite and original chemistry developed in your research group? Chiral chemistry and bioanalysis. How do you get into this specific field? Could you please share some experiences with our readers? When I just joined Jiangnan University, I tried to assemble gold nanoparticles by PCR and find new optical signal for template nucleic acid analysis. Interestingly, we found the complexity of gold assemblies was related to the PCR cycles. Especially, the gold dimers showed strong circular dichroism (CD) absorption in visible range while CD absorption of biomolecules or organic chemicals appeared in UV range. From then on, we focused on chiral nanoparticles and their biological effects. How do you supervise your students? I spent a lot of time with my students. It's enjoyable to solve experimental problems together with my students. The effective communication is very important. We always have heated discussions at our weekly meetings. It helps us to prepare in advance for potential difficulties in research and find a suitable way to attain experimental aims. What is the most important personality for scientific research? Great passion, fortitude, perseverance, and carefulness. What's your hobbies? What's your favorite book(s)? I like playing badminton. My favorite book is Li Ao Complement Set. How do you keep balance between research and family? I live in Jiangnan U campus. It's convenient. You don't have to cook and spend much time on the way to office. There is no need to divide your life into family time and work time. We can wechat with family members at any time and any places.

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Ultrasmall Copper (I) Sulfide Nanoparticles Prevent Hepatitis B Virus Infection

et al. 2021

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Hepatitis Bv irus (HBV) poses as evere threat to public health and social development. Here,wesynthesized 4 AE 0.5 nm copper (I) sulfide (Cu 2 S) nanoparticles (NPs) with 46 mdeg chiroptical property at 530 nm to selectively cleavage HBV core antigen (HBcAg) and effectively blocked HBV assembly and prevented HBV infection both in vitro and in vivo under light at 808 nm. Experimental analysis showed that the chiral Cu 2 SNPs specific bound with the functional domain from phenylalanine 23 (F 23 )t ol eucine 30 (L 30 )f rom HBcAg primary sequence and the cutting site was between amino acid residues F 24 and proline 25 (P 25 ). Under excitation at 808 nm, the intracellular HBcAg concentration was reduced by 95 %, and in HBV transgenic mice,t he levels of HBV surface antigen (HBsAg) and HBV DNAwere decreased by 93 %a nd 86 %, respectively.T ogether,t hese results reveal the potential nanomedicine for HBV control and providef resh tools for viral infection.

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Light‐Induced Chiral Iron Copper Selenide Nanoparticles Prevent β‐Amyloidopathy In Vivo

Cited by 14 publications

References 62 publications

Chiral Materials: Progress, Applications, and Prospects

Chiral Materials: Progress, Applications, and Prospects

Chiral Nanoprobes and Their Biological Effects

Ultrasmall Copper (I) Sulfide Nanoparticles Prevent Hepatitis B Virus Infection

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