Light‐Triggered Multifunctionality at Surfaces Mediated by Photolabile Protecting Groups

Abstract

Photoremovable protecting groups (PRPGs) are applied to organic surfaces, thin polymer films, and hydrogels to achieve light-based remote control of their (bio)chemical and physical properties. These can be localized (i.e. patterned), tunable by exposure dose, and generated on-demand. Using PRPGs with independent response to different wavelengths, multifunctional materials with a number of individually addressable functional states can be generated. Light-triggered polymerization, crosslinking, and degradation processes as well as release of attached molecules can be realized. Light-responsive surfaces and materials based on PRPGs open interesting possibilities for the next generation of instructive materials for cell culture and tissue regeneration.

Engineering von Proteinen an Oberflächen: Von komplementärer Charakterisierung zu Materialoberflächen mit maßgeschneiderten Funktionen

“…[132] Bisher wurden Glutathion und Biotin mit photospaltbaren Gruppen versehen, um die Wechselwirkung mit GST-markierten bzw. Im Allgemeinen basieren diese auf photospaltbaren Käfiggruppen wie Nitrobenzyl, 3,5-Dimethoxybenzoinester und Nitrodibenzofuran, die zunächst die Wechselwirkungen blockieren und später bei der Belichtung entfernt werden kçnnen, um die Aktivitätw iederherzustellen.…”

Targeted grafting of thermoresponsive polymers from a penetrative honeycomb structure for cell sheet engineering

“…[4][5][6] An attractive concept that may address this problem is to provide intelligent or responsive materials for particular environments. [8][9][10][11][12] Among all the biocompatible responsive polymers, poly(N-isopropylacrylamide) (pNIPAAm) has been mostly used due to its easy preparation and convenient modulation of the release and absorption of biomolecules and cells through its phase change at its lower critical solution temperature (LCST) of B32 1C, which is in a physiologically relevant range. [8][9][10][11][12] Among all the biocompatible responsive polymers, poly(N-isopropylacrylamide) (pNIPAAm) has been mostly used due to its easy preparation and convenient modulation of the release and absorption of biomolecules and cells through its phase change at its lower critical solution temperature (LCST) of B32 1C, which is in a physiologically relevant range.…”

A Polyurethane‐Based Positive Photoresist

“…Over the last few years, photoremovable protecting groups (PPGs) have been increasingly used for light‐mediated control of molecular architecture and derived properties in polymer coatings . PPGs or “cages” are chromophores that can be covalently attached to organic functional groups and subsequent cleaved by light exposure.…”