Lignan and Neolignan Derivatives from Magnolia denudata

Quantitative and Pattern Recognition Analyses for the Quality Evaluation of Magnoliae Flos by HPLC

“…Thus, these bioactive marker compounds are very useful to pattern recognition analysis. The twenty one Magnoliae Flos authentic samples collected from China and Korea and nine Magnoliae 26 and (2R,3S,3aR)-3a-allyl-5-methoxy-3-methyl-2-piperonyl 2,3,3a,6-tetrahydro-6-oxobenzofuran. 26 Their purities were above 95% as determined by HPLC and LC-MS/MS analysis, and the standard compound structures were shown Fig.…”

New Cytotoxic Phenolic Derivatives from Matured Fruits ofMagnolia denudata

“…[1][2][3][4] However, the chemical constituents of the matured fruits of this plant material have not been studied. This paper reports the isolation of two new phenolic derivatives, named as denudalide (1) and denudaquinol (2), from the matured fruits of M. denudata, as well as a known neolignan (denudatin A, 3).…”

Machilin G and Four Neolignans from Young Fruits ofMagnolia denudataShow Various Degrees of Inhibitory Activity on Nitric Oxide (NO) Production

“…The chemical constituents of the bark, leaves, and flower buds of M. denudata have been investigated, and it has been established that M. denudata contains many terpenoids, lignans, and neolignans. [1][2][3][4] However, the chemical constituents of the fruits of this plant and their biological activities have not been studied in detail.…”

“…Compound 4 was identified by comparing its 1 H-and 13 C-NMR data with those reported in the literature as isolated from the flower buds of Magnolia fargesii by Chen et al 5) Fargesone B, a stereoisomer of 4 at the 1 0 position, was recently isolated from the flower buds of M. denudata by Li et al 3) However, 4 has not been isolated from M. denudata. Compound 5 was identified by comparing its 1 H-and 13 C-NMR data and the value of optical rotation with those reported in the literature as isolated from the bark of Machilus thunbergii by Shimomura et al 6) Fifteen kinds of lignans and neolignans, including machilin G (5) have been isolated as inhibitors of cholesterol acyltransferase from Schisandra chinensis, M. thunbergii, and M. denudata by Kwon et al 7) However, they did not clarify the source plant for compound 5 in their paper.…”