Lignan glucoside from Sinopodophyllum emodi and its cytotoxic activity

One‐step Separation and Purification of Three Lignans and One Flavonol from Sinopodophyllum emodi by Medium‐pressure Liquid Chromatography and High‐speed Counter‐current Chromatography

“…Sinopodophyllum emodi (Wall.) Ying, mainly distributed in the Himalayan region and the Americas, is a member of the genus Podophyllum of the Berberidaceae family and has a long history of medicinal use in China for the treatment of cathartics and anthelmintics (Sudo et al ., ; Zhao et al ., ; Zhao et al ., ). The major bioactive constituents of S .…”

“…Sinopodophyllum emodi (Wall.) Ying, mainly distributed in the Himalayan region and the Americas, is a member of the genus Podophyllum of the Berberidaceae family and has a long history of medicinal use in China for the treatment of cathartics and anthelmintics (Sudo et al, 1998;Zhao et al, 2001;Zhao et al, 2011). The major bioactive constituents of S. emodi are lignans and flavonols, such as 4 0 -demethyl podophyllotoxin, podophyllotoxin, deoxypodophyllotoxin, dehydropodophyllotoxin, 4-demethyl-podophyllotoxin, 3 0 , 4 0 -demethylene-podophyllotoxin, podophyllotoxin-7 0 -O-b-Dglucopyranoside, 4-demethyl podophyllotoxin-7 0 -O-b-Dglucopyranoside, quercetin and kaempferol (Sun et al, 2011), which have been used extensively as supplements for chemotherapeutic cancer and hypertension treatments (Zhang and Ou, 1995;Izadifar and Baik, 2008).…”

Genetic diversity and structure of the threatened species Sinopodophyllum hexandrum (Royle) Ying

“…However, previous studies have focused on determining the chemical components (Giri and Lakshmi, 2000;Zhao et al, 2011), biological properties (Chattopadhyay et al, 2004), micropropagation (Nadeem et al, 2000), and phylogenetic evolution (Li et al, 2011) of this species. To date, limited publications have characterized the genetic diversity of S. hexandrum, and only studies in populations from the Northwestern Himalayan region are available (Alam et al, 2008;Alam et al, 2009;Naik et al, 2010).…”

Prenylated flavonoids from the fruits of Sinopodophyllum emodi and their cytotoxic activities

“…In addition, drug resistance is also a major hindrance to effective treatment. [3][4][5][6][7][8][9] As part of a program to search for cytotoxic natural products, we previously reported the isolation, characterization and cytotoxic activity of aryltetralin lactone and tetrahydrofuranoid lignans and preparative isolation of prenylated avonoids, sino-avonoids A-B from S. emodi. The dried ripe fruit of Sinopodophyllum emodi (Wall.)…”

“…2 Chinese medicinal herbs have become a promising source of potential new drugs. [9][10][11] In a further examination of the fruits of this plant, thirteen new prenylated avonoids, sino-avonoids C-O (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13), were obtained together with eleven known analogues (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24). Ying (Berberidaceae) called "Xiaoyelian" in Chinese, is a wellknown traditional Tibetan medicine for the treatment of amenorrhea, dead fetus, and placental retention.…”