Lignans from Saururus chinensis exhibit anti-inflammatory activity by influencing the Nrf2/HO-1 activation pathway

Jung, Yeon Woo; Lee, Bo Mi; Ha, Manh Tuan; Tran, Manh Hung; Kim, Jeong Ah; Lee, Suhyun; Lee, Jeong Hyung; Woo, Mi Hee

doi:10.1007/s12272-018-1093-4

Cited by 15 publications

(9 citation statements)

References 35 publications

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“…During CSC growth as multicellular spheres, constitutive NF-κB signaling was shown to be activated along with upregulation of NF-κB-dependent genes [49]. As the NF-κB signal is important for BCSCs and S. chinensis extracts showed significant anti-inflammatory effects [1,50], we examined the expression level and localization of the p65 subunit. Machilin D inhibited mammosphere formation through the NF-κB signaling pathway ( Figure 6).…”

Section: Discussionmentioning

confidence: 99%

“…Saururus chinensis is a medicinal perennial herbaceous plant that is mainly distributed in moist and wet locations in Japan, southern Korea, North America and China, and has been used in traditional medicine and resources to treat several diseases [1][2][3]. In cancer chemotherapy, synthetic anticancer agents are effective, but the repeated use of these agents in a complex tumor microenvironment often results in drug resistance [4].…”

Section: Introductionmentioning

confidence: 99%

“…Bioactive chemicals from S. chinensis have received increased attention as an alternative source of materials for cancer therapy. Several compounds, such as lignans, diterpenes, alkaloids, tannins, flavonoids, steroids, and lipids, isolated from S. chinensis possess a wide array of pharmacological and biochemical activities [5,6], such as antioxidant [7], antidiabetic [8], anti-inflammatory [1] and anticancer [9] activities.…”

Section: Introductionmentioning

confidence: 99%

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Machilin D, a Lignin Derived from Saururus chinensis, Suppresses Breast Cancer Stem Cells and Inhibits NF-κB Signaling

et al. 2020

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Cancer stem cells are responsible for breast cancer initiation, metastasis, and relapse. Targeting breast cancer stem cells (BCSCs) using phytochemicals is a good strategy for the treatment of cancer. A silica gel, a reversed-phase C18 column (ODS), a Sephadex LH-20 gel, thin layer chromatography, and high-performance liquid chromatography (HPLC) were used for compound isolation from Saururus chinensis extracts. The isolated compound was identified as machilin D by mass spectrometry and nuclear magnetic resonance (NMR). Machilin D inhibited the growth and mammosphere formation of breast cancer cells and inhibited tumor growth in a xenograft mouse model. Machilin D reduced the proportions of CD44+/CD24- and aldehyde dehydrogenase 1 (ALDH1)-positive cells. Furthermore, this compound reduced the nuclear localization of the NF-κB protein and decreased the IL-6 and IL-8 secretion in mammospheres. These results suggest that machilin D blocks IL-6 and IL-8 signaling and induces CSC death and thus may be a potential agent targeting BCSCs.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Machilin D, a Lignin Derived from Saururus chinensis, Suppresses Breast Cancer Stem Cells and Inhibits NF-κB Signaling

et al. 2020

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“…Different types of compounds were identified from Saururus species, including lignans, aristolactams, flavonoids, anthraquinones, and furanoditerpenes 9 . A number of structurally diverse lignans and neolignans were reported, some of which have exhibited a broad spectrum of biological activities including inhibitory activities against NF‐κB, HIV‐1 protease, arginase II, and hypoxia‐inducible factor 1 (HIF1) , cardiovascular effects, and cytotoxic activity 10,11 …”

Section: Introductionmentioning

confidence: 99%

“…9 A number of structurally diverse lignans and neolignans were reported, some of which have exhibited a broad spectrum of biological activities including inhibitory activities against NF-κB, HIV-1 protease, arginase II, and hypoxia-inducible factor 1 (HIF1), cardiovascular effects, and cytotoxic activity. 10,11 Previous studies demonstrated that S chinensis had potential benefits for the treatment of metabolic diseases such as hyperlipidemia 12 and hyperglycemia, 13,14 but the exact active constituents are not understood. MNSB is a dineolignan first isolated in 1983 from S chinensis.…”

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Manassantin B attenuates obesity by inhibiting adipogenesis and lipogenesis in an AMPK dependent manner

Cai

et al. 2021

FASEB j.

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Comparative pharmacokinetic study of six lignans in normal and diabetic rats after oral administration ofSaururus chinensisextract by LC–MS/MS

Chen

Luo

Liu

et al. 2021

Biomedical Chromatography

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Saururus chinensis (SC) possesses significant anti-diabetic activity and lignans were its major bioactive compounds. In this study, a rapid and sensitive ultra-highperformance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was established for simultaneous quantification of six lignans, namely (-)-(7R,8R)-machilin D (1), verrucesin (2), rel-(7S,8S,7 0 R,8 0 R)-3,3 0 ,4,4 0 ,5,5 0hexamethoxy-7.O.7 0 ,8.8 0 -lignan (3), manassantin A (4), manassantin B (5), and saucerneol F (6) in rat's plasma. It was validated with acceptable linearity (r ≥ 0.9922), accuracy (80.42-95.17%), precision (RSD ≤ 12.08%), and extraction recovery (80.36-93.45%). The method was successfully applied to the comparative pharmacokinetic study of the six lignans in normal and diabetic rats after oral administration of SC extract. Results showed that the areas under the plasma concentration-time curve (AUC 0 ! t and AUC 0 ! ∞ ) of (-)-(7R,8R)-machilin D, rel-(7S,-8S,7 0 R,8 0 R)-3,3 0 ,4,4 0 ,5,5 0 -hexamethoxy-7.O.7 0 ,8.8 0 -lignan, manassantin B, and saucerneol F in diabetic rats were significantly increased, and the plasma clearance (CL) of (-)-(7R,8R)-machilin D in diabetic rats was significantly decreased. However, the AUC 0 ! t and AUC 0 ! ∞ of verrucesin were significantly decreased, and its CL was significantly increased in diabetic rats compared with those in normal rats. These results indicated that there were remarkable differences in the pharmacokinetic parameters between the normal and diabetic rats. The pharmacokinetic studies might be beneficial for the clinical use of SC as hypoglycemic agent. K E Y W O R D S diabetic rats, ignan, pharmacokinetics, Saururus chinensis, UHPLC-MS/MS 1 | INTRODUCTION Saururus chinensis (SC; San Bai Cao in Chinese) has been widely used as a folk medicine in the treatment of edema, beriberi, jaundice, leucorrhea, urinary tract infections, hypertension, hepatitis diseases, and tumors in China, Japan, and South Korea (Meng et al., 2016; Wang et al., 2015). Previous pharmacological studies have shown that SC extract possesses significant anti-diabetic activity through inhibiting alpha-glucosidase activity (Hwang et al., 2007), activating peroxisome proliferator-activated receptor gamma (Hwang et al., 2002), and improving insulin resistance (Guo et al., 2010). In addition, SC extract can inhibit ADP-induced platelet aggregation (He et al., 1992). Phytochemical research studies indicated that SC contains various chemical constituents, such as lignans, flavonoids,

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Lignans from Saururus chinensis exhibit anti-inflammatory activity by influencing the Nrf2/HO-1 activation pathway

Cited by 15 publications

References 35 publications

Machilin D, a Lignin Derived from Saururus chinensis, Suppresses Breast Cancer Stem Cells and Inhibits NF-κB Signaling

Machilin D, a Lignin Derived from Saururus chinensis, Suppresses Breast Cancer Stem Cells and Inhibits NF-κB Signaling

Manassantin B attenuates obesity by inhibiting adipogenesis and lipogenesis in an AMPK dependent manner

Comparative pharmacokinetic study of six lignans in normal and diabetic rats after oral administration ofSaururus chinensisextract by LC–MS/MS

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