Lignans inhibit cell growth via regulation of Wnt/β-catenin signaling

Anti-leukemic activity of a four-plant mixture in a leukemic rat model

“…Furthermore, A. lappa contains arctigenin that is a phenyl propanoid dibenzyl butyrolactone lignan which has antioxidant, anti-inflammatory, and antitumor activities (Tamayo et al, 2000;Cho, Jang, Kim, & Kim, 2004;Awale et al, 2006;Zhao, Wang, & Liu, 2009). Arctigenin has been reported to inhibit the growth of leukocyte cancer cells (Matsumoto et al, 2006) and the proliferation of cancer cells by induction of apoptosis (Matsumoto et al, 2006) or by cell cycle arrest (Hausott, Greger, & Marian, 2003;Yoo et al, 2010;Jeong, Hong, Jeong, & Koo, 2011), nitric oxide synthase, interleukin-6 (Zhao et al, 2009), interleukin-2, interferon gamma gene expression in primary human T lymphocytes (Tsai et al, 2011), and TNF-a production in macrophages (Cho et al, 2004).…”

Chikusetsusaponin IVa methyl ester induces cell cycle arrest by the inhibition of nuclear translocation of β-catenin in HCT116 cells

“…To measure b-catenin/TCF transcriptional activity, we performed a luciferase reporter assay (reporter plasmids; TOP Flash, FOP Flash, and pRL-CMV) as described previously [12].…”

Pinoresinol Inhibits Proliferation and Induces Differentiation on Human HL60 Leukemia Cells

“…For instance, arctiin impaired the recovery of prostate cancer PC-3 cells by increasing the expression of the antiadhesion mucin MUC-1 and causing the detachment of the cells from the substrate (11). Arctiin, matairesinol, and arctigenin reduced the growth of human colon cancer SW480 cells through the inhibition of the Wnt/b-catenin signaling pathway (12). Matairesinol sensitized the androgen-dependent prostate cancer LNCaP cells to TRAILinduced apoptosis by reducing the Akt activity (13), in addition, 7-hydroxymatairesinol inhibited the growth of LNCaP tumor xenografts in athymic mice in vivo, increasing the apopotosis index and reducing the proliferation index of the tumor mass (14).…”