Lignin for white natural sunscreens

Lee, Sang Cheon; Tran, Thi Minh Thu; Choi, Joon Weon; Won, Keehoon

doi:10.1016/j.ijbiomac.2018.10.184

Cited by 117 publications

(62 citation statements)

References 32 publications

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“…Native lignin in lignocellulosic biomass undergoes structural changes and turns dark in color during separation processes, which are generally operated under harsh conditions such as high temperature and extreme pH values [9][10][11][12]. Recently, we extracted lignin under mild conditions (at room temperature with neutral solvents) and applied the obtained light-colored lignin to sunscreens [13]. Additionally, without isolating lignin from biomass, we introduced lignin-containing wood powders themselves as a natural sunscreen ingredient.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Application of Light-Colored Lignin Nanoparticles for Broad-Spectrum Sunscreens

et al. 2020

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Recently, natural sun blockers have been drawing considerable attention because synthetic UV filters could have adverse effects not only on humans but also on the environment. Even though lignin, the second most abundant renewable resource on earth, is a natural UV-absorbing polymer, its unfavorable dark color hampers its applications in sunscreens. In this work, we obtained light-colored lignin (CEL) from rice husks through cellulolytic enzyme treatment and subsequent solvent extraction under mild conditions and compared CEL to technical lignin from rice husks using the International Commission on Illumination L*a*b* (CIELAB) color space. Spherical nanoparticles of CEL (CEL-NP) were also prepared using a solvent shifting method and evaluated for broad-spectrum sunscreens. A moisturizing cream blended with CEL-NP exhibited higher sun protection factor (SPF) and UVA PF (protection factor) values than that with CEL. In addition, CEL-NP had synergistic effects when blended with an organic UV-filter sunscreen: CEL-NP enhanced the SPF and UVA PF values of the sunscreen greatly. However, there was no synergistic effect between CEL-NP and inorganic sunscreens. We expect nanoparticles of light-colored lignin to find high-value-added applications as a natural UV-blocking additive in sunscreens and cosmetics.

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Section: Introductionmentioning

confidence: 99%

Preparation and Application of Light-Colored Lignin Nanoparticles for Broad-Spectrum Sunscreens

et al. 2020

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“…Photoaging of the skin may be related to extrinsic factors such as ultraviolet ray in sunlight . Including UVB (290–320 nm) and UVA (320–400 nm) , UV accelerate skin aging and cause the culprit of diverse skin problems which contain the appearance of wrinkles, pigmentation and loss of elasticity of the skin . Compared to UVA, UVB generate serious biological harmful activities.…”

Section: Introductionmentioning

confidence: 99%

A Peptide YGDEY from Tilapia Gelatin Hydrolysates Inhibits UVB‐mediated Skin Photoaging by Regulating MMP‐1 and MMP‐9 Expression in HaCaT Cells

Xiao

Peng

Chen

et al. 2019

Photochem & Photobiology

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In this study, we investigated the protective effects of a peptide (YGDEY, Tyr‐Gly‐Asp‐Glu‐Tyr) isolated from tilapia skin gelatin hydrolysates (TGHs), against UVB‐induced photoaging in human keratinocytes (HaCaT) cells. Results showed that YGDEY significantly decreased levels of intracellular reactive oxygen species (ROS), increased antioxidant factors (Superoxide Dismutase, SOD and Glutathione, GSH) expression and maintained balance between GSH and GSSG in HaCaT cells. Comet assay shows that YGDEY can protect DNA from oxidative damage. Furthermore, it significantly inhibited MMP‐1 (collagenase) and MMP‐9 (gelatinase) expression and increased Type I procollagen production. In addition, the molecular docking study showed that YGDEY may form active sites with MMP‐1 and MMP‐9. Moreover, Western blot analysis was utilized to measure the protein levels of UVB‐induced mitogen‐activated protein kinase (MAPK) and nuclear factor‐kappa B (NF‐κB) signaling pathways. Therefore, these results suggested that YGDEY has a therapeutic effectiveness in prevention of UVB‐induced cellular damage, and it is a candidate worthy of being developed as a potential natural antioxidant and food additive.

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“…Lignin is the second most abundant renewable resource on earth, comprising a three-dimensional heterogenous and phenolic polymer network synthesized in the cell wall of higher plants. The term involves a variety of natural aromatic compounds obtained through the oxidative coupling of monomeric precursors [ 99 , 100 ]. The main monomers implicated in lignin structure, also known as monolignols, are coniferyl alcohol, sinapyl alcohol, and p -coumaryl alcohol ( Figure 2 ) [ 100 , 101 ].…”

Section: Natural Anti-cancer Agents For Skin Cancermentioning

confidence: 99%

“…Initially identified as an SIRT1 activator which regulates energy homeostasis and mitochondrial biogenesis within cells, it is now studied for its apoptosis promoting capacity by enhancing sensitivity to tumor Although it has not yet been converted into high-value products at large scales, lignin has shown to exhibit promising functions, including antioxidant, anti-microbial, and UV blocking. Additionally, as they do not cause cytotoxicity, lignin-based products could be applied for biomedical purposes [99]. In this context, lignin is a widely used bio-based UV-blocking material owing to its UV-absorbing phydroxyphenyl, guaiacyl, and syringyl phenylpropanoid units [99,102].…”

Section: Stilbenesmentioning

confidence: 99%

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Regenerative Wound Dressings for Skin Cancer

Pavel

Chircov

Rădulescu

et al. 2020

Cancers

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Skin cancer is considered the most prevalent cancer type globally, with a continuously increasing prevalence and mortality growth rate. Additionally, the high risk of recurrence makes skin cancer treatment among the most expensive of all cancers, with average costs estimated to double within 5 years. Although tumor excision is the most effective approach among the available strategies, surgical interventions could be disfiguring, requiring additional skin grafts for covering the defects. In this context, post-surgery management should involve the application of wound dressings for promoting skin regeneration and preventing tumor recurrence and microbial infections, which still represents a considerable clinical challenge. Therefore, this paper aims to provide an up-to-date overview regarding the current status of regenerative wound dressings for skin cancer therapy. Specifically, the recent discoveries in natural biocompounds as anti-cancer agents for skin cancer treatment and the most intensively studied biomaterials for bioactive wound dressing development will be described.

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Lignin for white natural sunscreens

Cited by 117 publications

References 32 publications

Preparation and Application of Light-Colored Lignin Nanoparticles for Broad-Spectrum Sunscreens

Preparation and Application of Light-Colored Lignin Nanoparticles for Broad-Spectrum Sunscreens

A Peptide YGDEY from Tilapia Gelatin Hydrolysates Inhibits UVB‐mediated Skin Photoaging by Regulating MMP‐1 and MMP‐9 Expression in HaCaT Cells

Regenerative Wound Dressings for Skin Cancer

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