(−)-Linalool inhibits in vitro NO formation: Probable involvement in the antinociceptive activity of this monoterpene compound

Peana, Alessandra Tiziana; Marzocco, Stefania; Popolo, Ada; Pinto, António

doi:10.1016/j.lfs.2005.05.065

Cited by 138 publications

(93 citation statements)

References 28 publications

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“…Linalool similarly reduced NO, IL-6, and TNFproduction. Peana et al reported that linalool inhibited NO production, 25) but this was not associated with iNOS expression. In this study, KEO and linalool suppressed iNOS and COX-2 expression.…”

Section: Discussionmentioning

confidence: 97%

Kuromoji (Lindera umbellata) Essential Oil Inhibits LPS-Induced Inflammation in RAW 264.7 Cells

Maeda

Yamazaki

Katagata

2013

Bioscience, Biotechnology, and Biochemistry

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Kuromoji (Lindera umbellata) essential oil (KEO) has long been used in Japan as a traditional medicine. It contains linalool (C 10 H 18 O), a naturally occurring small terpenoid. For this study, we investigated the antiinflammatory effect of KEO in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Mouse macrophage-like RAW 264.7 cells were stimulated with LPS. Then they were treated with 25 or 50 g/mL of KEO for 24 h. KEO suppressed LPS-induced pro-inflammatory cytokine production such as that of nitric oxide (NO), interleukin-6 (IL-6), and tumor necrosis factor-(TNF-) in a dose-dependent manner. In addition, inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA expression and protein levels were suppressed by treatment with KEO cells. In addition, by treatment with 25 or 50 g/mL of linalool showed the same anti-inflammatory effect. The results suggest that KEO and linalool can be regarded as a natural resource for use in anti-inflammatory therapeutic products.

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Section: Discussionmentioning

confidence: 97%

Kuromoji (Lindera umbellata) Essential Oil Inhibits LPS-Induced Inflammation in RAW 264.7 Cells

Maeda

Yamazaki

Katagata

2013

Bioscience, Biotechnology, and Biochemistry

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“…32 Moreover, the anti-inflammatory activity of linalool can be mainly due to the inducible nitric oxide synthase (iNOS) activity that controls other inflammatory factors, such as nitric oxide (NO), prostaglandins (PG) and cyclooxygenase. 61 Linalyl acetate shows, instead, strong lipoxygenase inhibitory effects that are mediated through the lipoxygenase pathway associated to the inflammation. 62…”

Section: In-vitro Anti-inflammatory Properties Of the Nanofibersmentioning

confidence: 99%

Alginate–lavender nanofibers with antibacterial and anti-inflammatory activity to effectively promote burn healing

et al. 2016

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This is an Accepted Manuscript, which has been through the Royal Society of Chemistry peer review process and has been accepted for publication.Accepted Manuscripts are published online shortly after acceptance, before technical editing, formatting and proof reading. Using this free service, authors can make their results available to the community, in citable form, before we publish the edited article. We will replace this Accepted Manuscript with the edited and formatted Advance Article as soon as it is available.You can find more information about Accepted Manuscripts in the Information for Authors. One of the current challenges in wound care is the development of multifunctional dressings that can both protect the wound from external agents and promote the regeneration of the new tissue. Here, we show the combined use of two naturally derived compounds, sodium alginate and lavender essential oil, for the production of bioactive nanofibrous dressings by electrospinning, and their efficacy for the treatment of skin burns induced by midrange ultraviolet radiation (UVB). We demonstrate that the engineered dressings reduce the risk of microbial infection of the burn, since they stop the growth of Staphylococcus aureus. Furthermore, they are able to control and reduce the inflammatory response that is induced in human foreskin fibroblasts by lipopolysaccharides, and in rodents by UVB exposure. In particular, we report a remarkable reduction of pro-inflammatory cytokines when fibroblasts or animals are treated with the alginate-based nanofibers. The down-regulation of cytokines production and the absence of erythema on the skin of the treated animals confirm that the here described dressings are promising as advanced biomedical devices for burn management.

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“…Lavandula augustifolia essential oil (LEO) and its major components, (-)-linalool and linalyl acetate, also presented anti-inflammatory properties in rats (Peana et al 2002). In an in vitro study, (-)-linalool decreased the production and the release of nitric oxide (NO) without interference in the prostaglandins pathway (Peana et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil

Silva

Luft

Lunardelli

et al. 2015

An. Acad. Bras. Ciênc.

135

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Several studies have investigated the antinociceptive, immunomodulatory and anti-inflammatory properties of compounds found in the lavender essential oil (LEO), however to date, there is still lack of substantial data. The objective of this study was to assess the antioxidant, anti-inflammatory and antinociceptive effects of lavender essential oil. The 1,1-diphenyl-2-picrylhydrazyl radical decolorization assay was used for antioxidant activity evaluation. The anti-inflammatory activity was tested using two models of acute inflammation: carrageenan-induced pleurisy and croton oil-induced ear edema. The antinociceptive activity was tested using the pain model induced by formalin. LEO has antioxidant activity, which is dose-dependent response. The inflammatory response evoked by carrageenan and by croton oil was reduced through the pre-treatment of animals with LEO. In the pleurisy model, the drug used as positive control, dexamethasone, was more efficacious. However, in the ear swelling, the antiedematogenic effect of the oil was similar to that observed for dexamethasone. In the formalin test, LEO consistently inhibited spontaneous nociception and presented a similar effect to that of tramadol. The results of this study reveal (in vivo) the analgesic and anti-inflammatory activities of LEO and demonstrates its important therapeutic potential.

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(−)-Linalool inhibits in vitro NO formation: Probable involvement in the antinociceptive activity of this monoterpene compound

Cited by 138 publications

References 28 publications

Kuromoji (Lindera umbellata) Essential Oil Inhibits LPS-Induced Inflammation in RAW 264.7 Cells

Kuromoji (Lindera umbellata) Essential Oil Inhibits LPS-Induced Inflammation in RAW 264.7 Cells

Alginate–lavender nanofibers with antibacterial and anti-inflammatory activity to effectively promote burn healing

Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil

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