Linear and Nonlinear Resonance Ejection of High Mass Ions with charge detection rectilinear ion trap mass spectrometer

Development of a High-Field “Brick” Mass Spectrometer with Extended Mass Range and Capable of Characterizing Native Proteins

“…A miniature digital ion trap, driven by a square wave, could analyze ions from 650 to 70,000 Th. − Great efforts have been made to develop particle ion trap mass spectrometers driven by a sinusoidal frequency scanning technique. For example, Peng and coworkers measured the cell and microparticle mass distribution by the use of a high-voltage rf amplifier. − Nie and coworkers described a miniature ion trap mass spectrometer that could measure polystyrene spheres, silica particles, and mice red blood cells . Chen and coworkers realized the detection of biological macromolecules such as IgG and IgA by using a high-voltage rf amplifier with an output of 800 V p‑p over a scanning frequency range from 300 to 100 kHz. , These studies utilized high-voltage op-amps (e.g., PA194 or PA94) as rf amplifiers to drive ion traps, which was beneficial for detecting the mass of a large particle or biological molecule.…”