Linkage mapping of <i>MMP1</i> to cattle chromosome 15

We report the identification of a single major chromosomal region controlling natural killer (NK) cell-like activity in rainbow trout (Oncorhynchus mykiss). A genetic map based on 484 AFLP and 39 microsatellite genotypes from 106 doubled haploid fish was constructed. These fish were produced by androgenesis from a hybrid of two clonal lines divergent in NK-like activity. NK-like activities for 75 of the doubled haploids were quantified by an in vitro chromium release assay utilizing (51)Cr-labeled YAC-1 target cells. Composite interval mapping revealed a single major quantitative trait locus (QTL) associated with NK-like activity in this rainbow trout model. Genetic mapping revealed this QTL to also be unlinked to: fragmented MHC class I and MHC class II regions, the leukocyte receptor cluster, the natural killer cell enhancement factor ( NKEF) gene, the RAG-1 gene, and two QTL associated with resistance to infectious pancreatic necrosis virus in rainbow trout. Collectively, these results extend the utility of rainbow trout as an immunological model and are consistent with the idea that a single chromosomal region homologous to the natural killer cell complex (NKC) located on syntenic portions of mouse chromosome (Chr) 6, human Chr 12, and rat Chr 4 may exist in a lower vertebrate model.

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A single major chromosomal region controls natural killer cell-like activity in rainbow trout

Zimmerman

Evenhuis

Thorgaard

et al. 2004

Immunogenetics

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Extension of a set of microsatellite markers for more precise identification of chum salmon Oncorhynchus keta walbaum

et al. 2011

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Quantitative Trait Loci × Maternal Cytoplasmic Environment Interaction for Development Rate in Oncorhynchus mykiss

et al. 2007

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Effects of maternal cytoplasmic environment (MCE) on development rate in rainbow trout were evaluated within a quantitative trait loci (QTL) analysis framework. Previous research had identified QTL for development rate in doubled haploid (DH) progeny produced from a cross between the Oregon State University (OSU) and the Swanson (SW) River rainbow trout clonal lines. In this study, progeny for QTL mapping were produced from a cross between the OSU and Clearwater (CW) River clonal lines. Doubled haploids were produced from the OSU 3 CW F 1 by androgenesis using eggs from different females (or MCEs); with androgenesis, the maternal nuclear genome was destroyed by irradiation and diploidy was restored by blocking the first embryonic cleavage by heat shock. All embryos were incubated at the same temperature and development rate quantified as time to hatch. Using a linkage map constructed primarily with AFLP markers, QTL mapping was performed, including MCE covariates and QTL 3 MCE effects in models for testing. The major QTL for development rate in the OSU3SW cross overlaps with the major QTL found in this OSU 3 CW cross; effects at this locus were the same across MCEs. Both MCE and QTL 3 MCE effects contribute to variability in development rate, but QTL 3 MCE were minor and detected only at smalleffect QTL.

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Linkage mapping of MMP1 to cattle chromosome 15

Cited by 3 publications

References 10 publications

A single major chromosomal region controls natural killer cell-like activity in rainbow trout

A single major chromosomal region controls natural killer cell-like activity in rainbow trout

Extension of a set of microsatellite markers for more precise identification of chum salmon Oncorhynchus keta walbaum

Quantitative Trait Loci × Maternal Cytoplasmic Environment Interaction for Development Rate in Oncorhynchus mykiss

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