Linking metal (Pb, Hg, Cd) industrial air pollution risk to blood metal levels and cardiovascular functioning and structure among children in Syracuse, NY

Hill, Dustin; Petroni, Michael; Larsen, David A.; Bendinskas, Kestutis; Heffernan, Kevin S.; Atallah-Yunes, Nader; Parsons, Patrick J.; Palmer, Christopher D.; MacKenzie, James A.; Collins, Mary B.; Gump, Brooks B.

doi:10.1016/j.envres.2020.110557

Cited by 26 publications

(16 citation statements)

References 40 publications

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“…Moreover, available tools for food assessment such as Food Frequency Questionnaire are of limited utility in dietary cadmium estimation, making the accurate evaluation of dietary factors (such as the individual amount or source of rice) more difficult [ 57 ]. Although occupational exposure, air pollution, contaminated water, living in industrial region, cosmetics, paint, and herbs have been identified as the potential sources of cadmium in the daily life [ 1 , 10 , 11 , 29 , 58 ], there were no differences in the relevant factors between BCL subclasses in our study, probably due to the exclusion of known occupational or accidental heavy metal poisoning at enrollment, the limitation of questionnaire-based investigation, and the advance of legislative regulations. Blood and urinary renal biomarkers were similar between BCL subclasses in our analysis, and hence longitudinal studies are required to clarify the impact of cadmium accumulation on renal biomarkers and outcomes, in which the novel renal biomarkers such as KIM-1, NAG and 8-OHdG could be utilized.…”

Section: Discussionmentioning

confidence: 99%

The Risk Factors of Blood Cadmium Elevation in Chronic Kidney Disease

Tsai

Hsu

Kung

et al. 2021

IJERPH

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Low-level cadmium exposure has adverse effects on chronic kidney disease (CKD); however, the risk factors for elevated blood cadmium levels (BCLs) have not been studied in CKD. We conducted a cross-sectional investigation in 200 CKD patients and stratified them by the tertiles of BCL to compare their demographic, environmental, and biochemical data. The factors associated with BCL were identified, and their effects were examined in subgroups. In the analyses, female sex, smoking, and CKD stage 5D were associated with high BCL, and statin was inversely correlated with BCL (odds ratio [95% confidence interval, CI], 6.858 [2.381–19.746], p < 0.001, 11.719 [2.843–48.296], p = 0.001, 30.333 [2.252–408.520], p = 0.010, and 0.326 [0.122–0.873], p = 0.026; deviations of BCL [nmol/L, 95% CI], 2.66 [1.33–4.00], p < 0.001, 3.68 [1.81–5.56], p < 0.001, 3.38 [0.95–5.82], p = 0.007, and −2.07 [−3.35–−0.78], p = 0.002). These factors were also independently correlated with BCL in subgroups, including non-dialysis CKD, hypertensive patients, non-smokers, and male patients. In conclusion, female sex, smoking, and CKD stage 5D were the major risk factors for elevated BCL; additionally, statins were negatively associated with BCL in CKD.

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Section: Discussionmentioning

confidence: 99%

The Risk Factors of Blood Cadmium Elevation in Chronic Kidney Disease

Tsai

Hsu

Kung

et al. 2021

IJERPH

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“…NADP was designed on the basis of the deprotected reaction of dithioacetal between NAÀ CHO and the corresponding thiol compounds triggered by Hg 2 + . During the catalysis of BF 3 • Et 2 O, the condensation reaction of NAÀ CHO and 1,3-dimercaptopropane in anhydrous CH 2 Cl 2 at room temperature yielded the sensor NADP, which was structurally characterized and validated with 1 H NMR, 13 C NMR, and HRMS spectroscopy (see Figures S5-S7 in the Supporting Information).…”

Section: Methodsmentioning

confidence: 99%

“…Due to the characteristic properties of Hg 2 + , it can combine with thiol groups in enzymes and proteins by passing through the biofilm. [11][12][13][14][15][16][17] Owing to the extremely hazardous properties of Hg 2 + , the U.S Environmental Protection Agency has explicitly stipulated that the maximum permissible level of mercury in drinking water should not exceed 2 ppb (10 nm). [18] Thus, considering its persistence in the environment and high toxicity in living organisms, [19][20][21][22][23][24][25][26] effective detection and disposal of Hg 2 + are of great significance for environmental protection and public health.…”

Section: Introductionmentioning

confidence: 99%

A Naphthalimide‐Based Fluorescent Probe for the Detection and Imaging of Mercury Ions in Living Cells

et al. 2021

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The selective and efficient monitoring of mercury (Hg 2 + ) contamination found in the environment and ecosystem has been carried out. Thus, a new 1,8-naphthalimide-based fluorescent probe NADP for the detection of Hg 2 + based on a fluorescence enhancement strategy has been designed and synthesized. The NADP probe can detect Hg 2 + with high selectivity and sensitivity and a low detection limit of 13 nm.The detection mechanism was based on a Hg 2 + -triggered deprotection reaction, resulting in a dramatic change in fluorescence from colorless to green at physiological pH. Most importantly, biological investigation has shown that the NADP probe can be successfully applied to the monitoring of Hg 2 + in living cells and zebrafish with low cytotoxicity.

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“…Approximately 80% of inhaled mercury is absorbed via the lungs and retained in the body (World Health Organization 1976). Although ingestion of contaminated food is a major source of Hg body levels (European Food Safety Authority (EFSA) 2012; European Food Safety Authority (EFSA) 2015), ground-level ambient air concentration of Hg is a significant predictor of body metal levels, also after controlling for covariates and other exposure variables (Hill 2020). Furthermore, in children living in industrial areas, a relatively high risk of exposure from hand-to-mouth intake is also possible (Abuduwailil et al, 2015).…”

Section: The Bioaccumulation Of Specific Metals In Exposed Childrenmentioning

confidence: 99%

“…Furthermore, the cement plant was the only significant anthropogenic source of Hg in the explored area. Finally, it has been suggested that air concentration of metals can be considered a predictor of body metal levels, independently from other exposure variables (Hill et al, 2020). The separate role of different ways of exposure to environmental metals, however, should be better examined by further investigations.…”

Section: Limitations Of the Studymentioning

confidence: 99%

Bioaccumulation of Toxic Metals in Children Exposed to Urban Pollution and to Cement Plant Emissions

Ciaula¹

2021

Expo Health

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Cement plants located in urban areas can increase health risk. Although children are particularly vulnerable, biomonitoring studies are lacking. Toenail concentration of 24 metals was measured in 366 children (6-10 years), who live and attend school in a city hosting a cement plant. Living addresses and schools were geocoded and attributed to exposed or control areas, according to modeled ground concentrations of PM 10 generated by the cement plant. Air levels of PM 10 and NO 2 were monitored. PM 10 levels were higher in the exposed, than in the control area. The highest mean PM 10 concentration was recorded close to the cement plant. Conversely, the highest NO 2 concentration was in the control area, where vehicular traffic and home heating were the prevalent sources of pollutants. Exposed children had higher concentrations of Nickel (Ni), Cadmium (Cd), Mercury (Hg), and Arsenic (As) than controls. These concentrations correlated each other, indicating a common source. Toenail Barium (Ba) concentration was higher in the control-than in the exposed area. The location of the attended school was a predictor of Cd, Hg, Ni, Ba concentrations, after adjusting for confounders. In conclusion, children living and attending school in an urban area exposed to cement plant emissions show a chronic bioaccumulation of toxic metals, and a significant exposure to PM 10 pollution. Cement plants located in populous urban areas seem therefore harmful, and primary prevention policies to protect children health are needed.

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Linking metal (Pb, Hg, Cd) industrial air pollution risk to blood metal levels and cardiovascular functioning and structure among children in Syracuse, NY

Cited by 26 publications

References 40 publications

The Risk Factors of Blood Cadmium Elevation in Chronic Kidney Disease

The Risk Factors of Blood Cadmium Elevation in Chronic Kidney Disease

A Naphthalimide‐Based Fluorescent Probe for the Detection and Imaging of Mercury Ions in Living Cells

Bioaccumulation of Toxic Metals in Children Exposed to Urban Pollution and to Cement Plant Emissions

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