Linseed hydrogel-mediated green synthesis of silver nanoparticles for antimicrobial and wound-dressing applications

Abstract

Polysaccharides are being extensively employed for the synthesis of silver nanoparticles (Ag NPs) having diverse morphology and applications. Herein, we present a novel and green synthesis of Ag NPs without using any physical reaction conditions. Linseed hydrogel (LSH) was used as a template to reduce Ag + to Ag 0 . AgNO 3 (10, 20, and 30 mmol) solutions were mixed with LSH suspension in deionized water and exposed to diffused sunlight. Reaction was monitored by noting the change in the color of reaction mixture up to 10 h. Ag NPs showed characteristic ultraviolet-visible (UV/Vis) absorptions from 410 to 437 nm in the case of sunlight and 397–410 nm in the case of temperature study. Transmission electron microscopy images revealed the formation of spherical Ag NPs in the range of 10–35 nm. Face-centered cubic array of Ag NPs was confirmed by characteristic diffraction peaks in powder X-ray diffraction spectrum. Ag NPs were stored in LSH thin films, and UV/Vis spectra recorded after 6 months indicated that Ag NPs retained their texture over the storage period. Significant antimicrobial activity was observed when microbial cultures (bacteria and fungi) were exposed to the synthesized Ag NPs. Wound-healing studies revealed that Ag NP–impregnated LSH thin films could have potential applications as an antimicrobial dressing in wound management procedures.

Natural product-based nanomedicines for wound healing purposes: therapeutic targets and drug delivery systems

“…74 The linseed hydrogel was another choice for the green synthesis of AgNPs, possessing the advantages of increasing the wound closure percentage and also the collagen content at the wound site. 60 Cassia auriculata L.-mediated AgNPs were effective on both incision and excision wound models in Wistar albino rats. Although the wound healing activity of Cas.…”

“…The most common metallic nanoparticles in biomedical and medicinal applications are silver-and gold-based nanostructures (nanoparticles, nanocomposites, and nanocoating), which have drawn the attention of researchers. Silver nanoparticles (AgNPs) and different silver salts have recently intrigued medical scientists in the fields of clinical and fundamental researches due to their excellent antibacterial and antimicrobial activities, 60 which could be attributed to their large surface area to volume ratio, and could be remarkably interesting due to growing microbial resistance against metal ions, antibiotics, and the development of resistant strains. 61 In addition to these characteristics, these nanoparticles possess the advantages of high chemical stability, antiviral, antifungal, and anti-inflammatory activities, and possibility to be incorporated into different composite structures, cosmetic products, food industry, and so on.…”

“…The administration of L. domesticum-mediated and linseed-mediated AgNPs to the animals increased the tensile strength of wound due to organization of collagen fibers. 60,73 Guar gum/AgNPs were other phytosynthesized medications possessing significant effect on the tensile strength and modulation of collagen deposition, in addition to regulation of keratinocytes and accelerating the essential re-epithelialization process. 94 In addition to the abovementioned nanostructures, green-synthesized AgNPs can be included into/or coated on the common dressings, electrospun nanofibers, and nanofibrous membranes.…”

Glucuronoxylan-mediated silver nanoparticles: green synthesis, antimicrobial and wound healing applications

“…16 Researchers have explored polysaccharides (i.e., non-toxic, biodegradable and economical reagents) 17,18 such as hydroxypropylcellulose, 19 dextran, 20 cellulose, 21 and chitosan 22 as reducing and stabilizing agents for the green synthesis of Ag NPs. Among polysaccharides, naturally occurring water swellable polysaccharides like arabinoxylans 23 and rhamnogalacturonan 24 are being explored nowadays for green synthesis of silver nanoparticles (Ag NPs) having diverse morphology and potential biological applications.…”

Green synthesis of polysaccharide-based inorganic nanoparticles and biomedical aspects

“…Thus, it was suggested that these particles have potential wound healing applications [112]. Other studies using hydrogel-mediated polysaccharide-based (e.g., linseed, chitosan, or Glucuronoxylan isolated from seeds of Mimosa pudica) AgNPs have also shown wound healing capabilities, mainly due to their antimicrobial characteristics and stimulation of the reepithelialization and granulation tissue formation [15,113].…”