Lipid accumulation product in relation to 10-year cardiovascular disease incidence in Caucasian adults: The ATTICA study

Kyrou, Ioannis; Panagiotakos, Demosthenes B.; Kouli, Georgia Maria; Georgousopoulou, Ekavi; Chrysοhoou, Christina; Tsigos, Constantine; Tousoulis, Dimitrios; Pitsavos, Christos

doi:10.1016/j.atherosclerosis.2018.10.015

Cited by 57 publications

(37 citation statements)

References 44 publications

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“…V/S ratio was independently associated with both large and small vessel lesions in apparently healthy subjects in another previous study 16. LAP can surpass the BMI in the prediction of CVD risk as an index describing lipid excess accumulation calculated according to the fasting TG level and WC, and there is a positive association between LAP and long-term CVD incidence in CVD-free Caucasian adults 17…”

Section: Discussionmentioning

confidence: 79%

The Correlation between the Ratio of Visceral Fat Area to Subcutaneous Fat Area on Computed Tomography and Lipid Accumulation Product as Indexes of Cardiovascular Risk

Kwon

Han

2019

JOMES

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BackgroundVisceral obesity and cardiovascular disease are closely related. Research on relevant indexes of cardiovascular disease is particularly important. One of these indexes is lipid accumulation product (LAP). However, the relationship between LAP and the ratio of visceral fat area to subcutaneous fat area (V/S ratio) remains unclear.MethodsIndividuals who visited the university hospital health promotion center and underwent abdominal computed tomography (CT) were included in the study. We analyzed the V/S ratio obtained using CT with cardiovascular factors and indexes. Standardized coefficients were used to obtain uniform units of all independent variables, and the relationship between LAP and V/S ratio was determined using multiple logistic regression analysis.ResultsA positive correlation between the V/S ratio and LAP was observed even after adjustment for age, smoking history, alcohol drinking history, and exercise (P<0.001). The highest quartile of LAP was independently associated with abdominal obesity (odds ratio [OR], 1.160; 95% confidence interval [CI], 1.093–1.232) and visceral fat ≥100 cm2 (OR, 1.018; 95% CI, 1.010–1.026), but not with hypertension or diabetes.ConclusionLAP is closely related to the V/S ratio and can be used to predict the condition of visceral fat tissue.

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Section: Discussionmentioning

confidence: 79%

The Correlation between the Ratio of Visceral Fat Area to Subcutaneous Fat Area on Computed Tomography and Lipid Accumulation Product as Indexes of Cardiovascular Risk

Kwon

Han

2019

JOMES

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“…Moreover, subjects with fasting blood glucose >125 mg/dL or on antidiabetic treatment were classified as having diabetes. Selected circulating pro-inflammatory biomarkers were also measured, namely high sensitivity C-reactive protein (CRP), as well as tumour necrosis factor α (TNFα) and interleukin-6 (IL-6), following the specific protocols 20. Furthermore, resting arterial blood pressure (average of three recordings in the sitting position) was also measured at baseline, and individuals exhibiting an average blood pressure ≥140/90 mmHg or taking antihypertensive medication(s) were categorised as hypertensive.…”

Section: Methodsmentioning

confidence: 99%

Skeletal muscle mass in relation to 10 year cardiovascular disease incidence among middle aged and older adults: the ATTICA study

Tyrovolas

Panagiotakos²,

Georgousopoulou³

et al. 2019

J Epidemiol Community Health

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BackgroundSkeletal muscle mass (SMM) is inversely associated with cardiometabolic health and the ageing process. The aim of the present work was to evaluate the relation between SMM and 10 year cardiovascular disease (CVD) incidence, among CVD-free adults 45+ years old.MethodsATTICA is a prospective, population-based study that recruited 3042 adults without pre-existing CVD from the Greek general population (Caucasians; age ≥18 years; 1514 men). The 10 year study follow-up (2011–2012) captured the fatal/non-fatal CVD incidence in 2020 participants (50% men). The working sample consisted of 1019 participants, 45+ years old (men: n=534; women: n=485). A skeletal muscle mass index (SMI) was created to reflect SMM, using appendicular skeletal muscle mass (ASM) standardised by body mass index (BMI). ASM and SMI were calculated with specific indirect population formulas.ResultsThe 10 year CVD incidence increased significantly across the baseline SMI tertiles (p<0.001). Baseline SMM showed a significant inverse association with the 10 year CVD incidence (HR 0.06, 95% CI 0.005 to 0.78), even after adjusting for various confounders. Additionally, participants in the highest SMM tertile had 81% (95% CI 0.04 to 0.85) lower risk for a CVD event as compared with those in the lowest SMM tertile.ConclusionsThe presented findings support the importance of SMM evaluation in the prediction of long-term CVD risk among adults 45+ years old without pre-existing CVD. Preservation of SMM may contribute to CVD health.

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“…Simultaneously, the LAP is considered as an better index compared with BMI to recognize CVD risk as an index which describes lipid over-accumulation based on WC and fasting triglycerides (36). In this study, compared with BMI, VAI and LAP were more sensitive to re ect the change of lipid pattern in CKD patients.…”

Section: Resultsmentioning

confidence: 84%

What is the Impact of Sex on Cardiovascular Disease Risk Factors in Patients with Chronic Kidney Diseases in China: A Cross-sectional Study

Wang

Zhang

Luo

et al. 2020

Preprint

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Background: It is controversial about the sex differences in the association of chronic kidney diseases (CKD) and cardiovascular disease (CVD) risk. Thus, we examined CVD risk makers of CKD and non-CKD men and women in China, especially some “non-traditional” ones.Methods: This cross-sectional study used 7999 participants from the China Health and Nutrition Survey in 2009. This study examined the “traditional” risk factors and of CVD, such as lipoprotein cholesterol (LDL-C), total cholesterol (TC) and non-high density lipoprotein cholesterol(non-HDL-C).Also, the “non-traditional” risk factors of CVD were calculated, such as lipoprotein (a)(Lp(a)), white blood cell (WBC) count, visceral adiposity index (VAI) and lipid accumulation product (LAP).Results: Compared with men with CKD, higher levels of TC and LDL-C were observed in women with CKD. Furthermore, compared with men with CKD, the relative difference of WBC count was greater between women with CKD and their non-CKD ones. Meanwhile, the level of LAP and VAI of women with CKD were higher than men with CKD, which indicate the visceral obese. We also observed that the sex by CKD status interactions were statistically significant for TC, LDL-C, non-HDL-C, LAP, VAI and Lp(a) (all p <0.05). After adjusted the covariates, the sex differences effect on CVD risk factors among CKD patients couldn’t be eliminated as well. Conclusions: In CKD situation, women had greater lipid profiles and put on more visceral adiposity than men, which may indicate a higher CVD risk of women with CKD.

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Lipid accumulation product in relation to 10-year cardiovascular disease incidence in Caucasian adults: The ATTICA study

Cited by 57 publications

References 44 publications

The Correlation between the Ratio of Visceral Fat Area to Subcutaneous Fat Area on Computed Tomography and Lipid Accumulation Product as Indexes of Cardiovascular Risk

The Correlation between the Ratio of Visceral Fat Area to Subcutaneous Fat Area on Computed Tomography and Lipid Accumulation Product as Indexes of Cardiovascular Risk

Skeletal muscle mass in relation to 10 year cardiovascular disease incidence among middle aged and older adults: the ATTICA study

What is the Impact of Sex on Cardiovascular Disease Risk Factors in Patients with Chronic Kidney Diseases in China: A Cross-sectional Study

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