Lipid-laden macro phages in bone marrow of leprosy patients

Abstract

Summary While conducting a study to observe bone marrow cytomorphological changes in multi bacillary leprosy, lipid laden macrophages as seen in sphingolipi doses were noted. The present study was planned to observe the occurrence and morphological characterization of these macrophages in various types of leprosy. Bone marrow records from 48 cases of paucibacillary and 72 cases of multibacill ary leprosy were analysed. The macrophages accounting at the most for 3·5% of marrow cells were observed in 5 cases of paucibacillary and 43 cases of multi bacillary leprosy with a maximum incidence being observed in patients with ENL (16/17). The lipid present in the cytoplasm of these cells could be derived from the lipid of the cell wall of My cobacterium leprae. To the best of our knowledge, these cells have not been reported in leprosy so fa r.

Evaluation of Changes in Haematological Profile of Cerebral Malaria Patients in Enugu State, Southeast, Nigeria

“…The pathogenesis of anaemia in malaria is multifactorial. A complex chain of pathogenetic processes involving mechanical destruction of parasitized RBCs, marrow suppression, ineffective erythropoiesis, and accelerated immune destruction of nonparasitized RBCs have been implicated [11]. Thrombocytopenia was a common observation in falciparum malaria with spontaneous recovery on treatment but in this study, it showed increased thrombocytes.…”