Lipid peroxidation and antioxidant enzyme activities in infertile men: correlation with semen parameter

Abdallah, Ferjani Ben; Dammak, Ines; Attia, Hamadi; Hentati, Basma; Keskes, Leila

doi:10.1002/jcla.20297

Cited by 62 publications

(58 citation statements)

References 29 publications

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“…It seems that lipid peroxidation of human spermatozoa may cause the loss of motility and that SOD may inhibit this lipid peroxidation. The findings from studies of Ben Abdallah et al and Kumar et al [41,42] are in contrast with our data. We also find a significant negative correlation between SOD activity and volume of human semen, but we did not find any information for and against these findings.…”

Section: Discussioncontrasting

confidence: 99%

Zinc and Iron Concentration and SOD Activity in Human Semen and Seminal Plasma

Marzec-Wróblewska

Kamiński

Łakota

et al. 2010

Biol Trace Elem Res

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The aim of the present study was to measure zinc (Zn) and iron (Fe) concentration in human semen and superoxide dismutase (SOD) activity in seminal plasma and correlate the results with sperm quality. Semen samples were obtained from men (N = 168) undergoing routine infertility evaluation. The study design included two groups based on the ejaculate parameters. Group I (n = 39) consisted of males with normal ejaculate (normozoospermia), and group II (n = 129) consisted of males with pathological spermiogram. Seminal Zn and Fe were measured in 162 samples (group I, n = 38; group II, n = 124) and SOD activity in 149 samples (group I, n = 37; group II, n = 112). Correlations were found between SOD activity and Fe and Zn concentration, and between Fe and Zn concentration. SOD activity was negatively associated with volume of semen and positively associated with rapid progressive motility, nonprogressive motility, and concentration. Negative correlation was stated between Fe concentration and normal morphology. Mean SOD activity in seminal plasma of semen from men of group I was higher than in seminal plasma of semen from men of group II. Fe concentration was higher in teratozoospermic males than in males with normal morphology of spermatozoa in group II. Our results suggest that Fe may influence spermatozoa morphology.

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Section: Discussioncontrasting

confidence: 99%

Zinc and Iron Concentration and SOD Activity in Human Semen and Seminal Plasma

Marzec-Wróblewska

Kamiński

Łakota

et al. 2010

Biol Trace Elem Res

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“…It is known that alterations in intracellular ROS could be associated with male idiopathic infertility [16]. These results are in agreement with data of our previous publications [18] and some other studies [4,27] also demonstrating that the increased malone-dialdehydelevel(evaluatedasTBARS)insemenwassignificantlyhigherinoligoasthenozoospermic and asthenozoospermic groups compared with normozoospermic group.…”

Section: Resultssupporting

confidence: 93%

Glutathione antioxidant protection system in ejaculated spermatozoa of infertile men with different forms of pathospermia

Фафула¹,

Onufrovych²,

Vorobets³

et al. 2017

Biol. Stud.

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The level of the products of lipid peroxidation measured as the thiobarbituric acid reactive substances (TBARS) and activity of enzymes of glutathione antioxidant protection system in spermatozoa were studied. It was shown that mean levels of TBARS in sperm cells of infertile men with oligozoo-, astenozoo-, oligoastenozoo-and leucocytospermia were 1.6-, 2.0-, 2.0-and 2.7-fold higher, respectively, compared with such levels in the fertile men. The glutathione peroxidase activity was decreased 2.2-fold in patients with oligozoospermia, 2.8-fold in patients with astenozoo-and oligoastenozoospermia and 3.8-fold in patients with leucocytospermia. It was found that glutathione reductase activity in patients with oligozoo-, astenozoo-, oligoastenozoo-and leucocytospermia were 2.3-, 1.6-, 1.7-and 3.3-fold lower than that in normozoospermic men, respectively. In addition, the glutathione transferase activity was decreased 1.8-2.1-fold in patients with oligozoo-, astenozoo-and oligoastenozoospermia and 5.0-fold in patients with leuco cytospermia in comparison with healthy donors. The most significant changes were observed in the infertile men with leucocytospermia. This manifestation could be explained by the fact that white blood cells stimulate the formation of reactive oxygen species, induction and development of oxidative stress in sperm cells.

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“…Indeed, antioxidant level in the blood correlated with sperm counts and motility (Shamsi et al, 2009(Shamsi et al, , 2010. To strengthen these, other literature reported the presence of malondialdehyde levels correlates well with motility and acrosome anomalies (Ben et al, 2009;Tavilani ,2005). Although decrease in motility did not necessarily imply DNA fragmentation in the sperm (Lin et al, 2008), the decline of large portions (over 10-20%) of motile sperms in the semen may indeed point to a decline in degrees of fertility.…”

Section: Discussionmentioning

confidence: 78%

Ketamine effects on the urogenital system—changes in the urinary bladder and sperm motility

Tan

Chan

Wai

et al. 2011

Microscopy Res & Technique

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Different doses of ketamine (10 mg/kg, 20 mg/kg, 30 mg/kg, 40 mg/kg, 50 mg/kg, and 60 mg/kg) were injected i.p. (I.P.), respectively, to male ICR mice to determine the optimal dosage for chronic administration. At and above 40 mg/kg I.P. injection, mice had almost no hindlimb movement during swimming test. Subsequently, 30 mg/kg was used as the dose for the study in the toxicity of long-term ketamine administration on urinary bladder and sperm motility. The treatment group were subdivided into two (n = 10 each group); one received daily ketamine treatment i.p. for 3 months and another group for 6 months. Corresponding number of mice in control groups (n = 5 each group) received saline injection instead of ketamine. Terminal dUTP nick and labeling (TUNEL) study and Sirius red staining were carried out on the sectioned slides of the urinary bladders to study the degree of apoptosis in both epithelium and muscular layers of the urinary bladder and the relative thickness of the muscular layers in this organ was also computed. Apoptosis in the bladder epithelium was observed initially in the 3-month ketamine treated mice and the number of apoptotic cells was significantly different (P < 0.05) between the 3-month and 6-month ketamine treated mice and the control. The relative thickness of muscular layers in the bladder wall also decreased significantly (P < 0.05) when the 6-month treated mice and the control were compared. Sirius red staining revealed increase of collagen in the urinary bladder of the treated mice, most evidently 6 months after ketamine treatment. In addition, the sperm motility was studied and there was a statistically significant difference between the control and ketamine treated groups in the percentages of sperms which were motile (P < 0.05). This suggested that the chronic administration of ketamine affected the genital system as well.

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Lipid peroxidation and antioxidant enzyme activities in infertile men: correlation with semen parameter

Cited by 62 publications

References 29 publications

Zinc and Iron Concentration and SOD Activity in Human Semen and Seminal Plasma

Zinc and Iron Concentration and SOD Activity in Human Semen and Seminal Plasma

Glutathione antioxidant protection system in ejaculated spermatozoa of infertile men with different forms of pathospermia

Ketamine effects on the urogenital system—changes in the urinary bladder and sperm motility

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