Lipid peroxidation and DNA damage in apnea patients with or without metabolic syndrome

Yardım-Akaydin, Sevgi; Caliskan-Can, Emel; Gökalp, Firat; Fırat, Hikmet; Şimşek, Bolkan

doi:10.1111/sbr.12012

Cited by 6 publications

(3 citation statements)

References 34 publications

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“…It is assumed that markers of oxidative stress may be increased due to repeated short cycles of intermittent hypoxia followed by reoxygenation, during which free radicals are formed causing oxidative damage to biomacromolecules and disrupting vascular homeostasis [ 37 ]. These processes may result in increased cardiovascular and cerebrovascular risk in individuals with sleep-disordered breathing [ 38 , 39 ]. Significantly increased levels of lipoperoxides in plasma were found in individuals with OSA compared to the control group.…”

Section: Resultsmentioning

confidence: 99%

The impact of sleep apnea syndrome on the altered lipid metabolism and the redox balance

et al. 2021

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Background Obstructive sleep apnea (OSA) is a disorder with a significant risk for cardiovascular diseases. Dyslipidemia and redox imbalance belong to potential mechanisms linking OSA with the development of vascular diseases. The main aim of this study was the evaluation of the presence of lipid abnormalities in OSA patients, focusing on small dense low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subfractions and determination of the redox imbalance by evaluating the marker of oxidative damage to plasma lipids - lipoperoxides. Methods The study included 15 male subjects with polysomnographically confirmed OSA and 16 male healthy controls. Plasma levels of total cholesterol, LDL and HDL and their subfractions, triacylglycerols and lipoperoxides were determined in all study individuals. Plasma LDL and HDL subfractions were separated by the Lipoprint system which is a polyacrylamide gel electrophoresis. Lipoperoxide levels were determined spectrophotometrically. Results OSA patients had significantly higher triacylglycerols, total cholesterol and LDL-cholesterol compared to healthy controls. HDL cholesterol was not significantly different. Of the LDL and HDL subfractions, OSA patients had significantly lower levels of atheroprotective LDL1 and large HDL subfractions and significantly higher levels of atherogenic small dense LDL3–7 and HDL8–10 subfractions. Lipoperoxide levels in patients with OSA were significantly elevated compared to healthy individuals. Conclusion The lipoprotein pro-atherogenic phenotype was found in individuals with OSA characterized by increased levels of atherogenic lipoprotein subfractions and reduced levels of atheroprotective subfractions. In addition, a plasma redox imbalance was found in patients with OSA compared to controls by detecting higher oxidative damage to lipids. Abnormalities in lipoprotein levels in patients with OSA, as well as the redox imbalance, could lead to an acceleration of the atherosclerotic process in predisposed individuals and thus represent a significant risk factor for vasular diseases.

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Section: Resultsmentioning

confidence: 99%

The impact of sleep apnea syndrome on the altered lipid metabolism and the redox balance

et al. 2021

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“…The adjusted values of 8-OHDG shown no difference between OSA groups. However, they were higher in every OSA group compared to controls (control 25.55 ± 3.76 vs. mild 31.72 ± 4.01 vs. moderate 32.06 ± 5.14 vs. severe 32.48 ± 4.26 nM/creatinine mM) [ 65 ].…”

Section: Resultsmentioning

confidence: 99%

Is the Oxidative Stress in Obstructive Sleep Apnea Associated with Cardiovascular Complications?—Systematic Review

Fiedorczuk

Stróżyński

Olszewska

2020

JCM

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Obstructive sleep apnea (OSA) is a prevalent, underdiagnosed disease and is considered an independent risk factor for cardiovascular disease. The exact mechanism of cardiovascular complications (CVC) development as a complication of OSA is not entirely understood. Oxidative stress is suspected to be the essential factor in initiating various comorbidities in OSA. Biomarkers of nonenzymatic lipid and protein peroxidation, DNA repair and antioxidant capabilities measured in serum, plasma and urine are frequently used to assess the presence of oxidative stress. We conducted a systematic review and quality assessment of available observational analytic studies to determine whether there is an association between oxidative stress and OSA in patients with prevalent CV disease compared to (a) patients with prevalent CV disease but no OSA, (b) patients with prevalent CV disease and less severe OSA and (c) patients with OSA and no overt CV disease. This systematic review demonstrated that, while oxidative stress is associated with OSA, there was no clear difference in the severity of oxidative stress between OSA patients with or without cardiovascular complications.

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“…Conversely, age (t = −2.06, p = 0.049), assay type (t = 2.31, p = 0.03) and publication year (t = 2.08, p = 0.048) were significantly associated with the SMD. In order to evaluate the relationship between effect size and disease severity we performed a meta-analysis in a sub-group of nine studies reporting MDA concentrations in groups with different disease severity [32,35,37,38,42,45,47,49,52]. The forest plot for MDA concentrations in mild and severe OSA patients is reported in Figure 8.…”

Section: Resultsmentioning

confidence: 99%

Circulating Malondialdehyde Concentrations in Obstructive Sleep Apnea (OSA): A Systematic Review and Meta-Analysis with Meta-Regression

Pau

Zinellu²,

Fois

et al. 2021

Antioxidants

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Oxidative stress induced by nocturnal intermittent hypoxia plays a significant pathophysiological role in obstructive sleep apnea (OSA). Malondialdehyde (MDA), one of the most commonly investigated markers of lipid peroxidation, might assist with the monitoring of oxidative balance in OSA. We conducted a systematic review and meta-analysis to evaluate the differences in circulating MDA concentrations between patients with OSA and non-OSA controls. A systematic search was conducted in the electronic databases Pubmed, Web of Science, Scopus and Google Scholar from inception to December 2020 by using the following terms: “malondialdehyde” or “MDA”; and “Obstructive Sleep Apnea Syndrome”, “OSAS” or “OSA”. We identified 26 studies in 1223 OSA patients and 716 controls. The pooled MDA concentrations were significantly higher in patients with OSA (standardized mean difference (SMD) 1.43 μmol/L, 95% confidence interval (CI) 1.03 to 1.83 μmol/L, p < 0.001). There was extreme heterogeneity between the studies (I2 = 92.3%, p < 0.001). In meta-regression analysis, the SMD was significantly associated with age, the assay type used and publication year. In our meta-analysis, MDA concentrations were significantly higher in OSA patients than in controls. This finding suggests that MDA, which is a marker of lipid peroxidation, is involved in the pathogenesis of OSA and provides insights for future studies investigating its potential clinical use.

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Lipid peroxidation and DNA damage in apnea patients with or without metabolic syndrome

Cited by 6 publications

References 34 publications

The impact of sleep apnea syndrome on the altered lipid metabolism and the redox balance

The impact of sleep apnea syndrome on the altered lipid metabolism and the redox balance

Is the Oxidative Stress in Obstructive Sleep Apnea Associated with Cardiovascular Complications?—Systematic Review

Circulating Malondialdehyde Concentrations in Obstructive Sleep Apnea (OSA): A Systematic Review and Meta-Analysis with Meta-Regression

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