Lipid peroxidation in lung of rat stressed by immobilization: Effects of vitamin E supplementation

S, Kovacheva; Ribarov, S. R.

doi:10.1007/bf00181877

Cited by 8 publications

(9 citation statements)

References 17 publications

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“…A daily i.p. injection of 100 mg/kg vitamin E for 7 days resulted in about a 3.5-fold increase in vitamin E content in the lungs (Kovacheva and Ribarov 1995), whereas the same regimen for 4 days decreased lipid peroxidation in the liver (Hidalgo et al 1988). In addition, a 5-day vitamin E i.v.…”

Section: Discussionmentioning

confidence: 96%

“…Accordingly, the placebo groups were injected with vehicle. This vitamin E regime was chosen because similar ones have previously increased vitamin E concentration in muscle (Van Der Meulen et al 1997) and lung (Kovacheva and Ribarov 1995) and inhibited lipid peroxidation in the lungs (Kovacheva and Ribarov 1995) and the liver (Hidalgo et al 1988). Furthermore, our rationale was to adopt a vitamin E administration regime in rats that approximates the doses most frequently used in human studies at the lower end of the supplementation period (i.e.…”

Section: Supplementationmentioning

confidence: 99%

“…with 100 mg/kg body mass of DL-a-tocopheryl acetate per day for 5 consecutive days prior to exercise or examination, respectively (Kovacheva and Ribarov 1995;Hidalgo et al 1988). Vitamin E was diluted in grain oil at a concentration of 4% (w/v).…”

Section: Supplementationmentioning

confidence: 99%

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Effect of 5-day vitamin E supplementation on muscle injury after downhill running in rats

et al. 2011

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Antioxidant supplementation has been suggested to prevent exercise-induced muscle injury, but the findings are inconsistent. The objective of this study was to investigate the potential protective role of vitamin E treatment against eccentric exercise-induced muscle injury by examining morphological and functional alterations in rat soleus muscle after downhill running as well as muscle injury markers in the blood. Sixty adult male Wistar rats were randomly assigned to vitamin E-treated or placebo-treated groups studied at rest, immediately post-exercise or 48 h post-exercise (n = 10 per group). Vitamin E was administered by daily intraperitoneal injections of 100 mg/kg body mass of DL: -α-tocopheryl acetate for five consecutive days prior to exercise, resulting in the doubling of its plasma concentration. Downhill running resulted in significant (P < 0.05) changes in all injury markers for the placebo-treated rats at 0 and 48 h post-exercise. However, significantly smaller soleus muscle single-twitch tension (P (t)) and unfused (40 Hz) tetanic force, and greater plasma creatine kinase (CK) and lactate dehydrogenase (LD) activities compared with the control were found only immediately post-exercise for the vitamin E-treated rats (P < 0.05). Maximal tetanic force (P (o)) did not decline significantly compared to sedentary controls at neither time points measured. The vitamin E-treated rats had significantly (P < 0.05) higher soleus muscle P (t) immediately post-exercise than the placebo-treated rats as well as lower plasma CK and LD activity 48 h post-exercise. However, there was no difference in P (o) decline between groups at either time points measured. Vitamin E-treated rats had less pronounced morphological alterations in muscle in the immediate and 48-h post-exercise period. In conclusion, the effect of short-term vitamin E supplementation against eccentric exercise-induced muscle injury did not appear to be physiologically significant, because vitamin E failed to prevent the decline in the functional measure of P (o) compared to the placebo conditions.

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Section: Discussionmentioning

confidence: 96%

Section: Supplementationmentioning

confidence: 99%

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Effect of 5-day vitamin E supplementation on muscle injury after downhill running in rats

et al. 2011

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“…The lungs and the pulmonary vasculature are potentially at high risk of injury mediated by oxygen-derived free radicals and lipid peroxidation free radicals (6). There are at least two reasons for this: i) the lung tissue contains unsaturated fatty acids, which are a substrate for lipid peroxidation, and ii) lungs are exposed to higher oxygen concentrations than any other organ in the body (6).…”

Section: Introductionmentioning

confidence: 99%

“…There are at least two reasons for this: i) the lung tissue contains unsaturated fatty acids, which are a substrate for lipid peroxidation, and ii) lungs are exposed to higher oxygen concentrations than any other organ in the body (6). Pulmonary antioxidant defenses are widely distributed and include both enzymatic and nonenzymatic systems.…”

Section: Introductionmentioning

confidence: 99%

Lipid peroxidation and total radical-trapping potential of the lungs of rats submitted to chronic and sub-chronic stress

Torres

Gamaro

et al. 2004

Braz J Med Biol Res

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Exposure to stress induces a cluster of physiological and behavioral changes in an effort to maintain the homeostasis of the organism. Long-term exposure to stress, however, has detrimental effects on several cell functions such as the impairment of antioxidant defenses leading to oxidative damage. Oxidative stress is a central feature of many diseases. The lungs are particularly susceptible to lesions by free radicals and pulmonary antioxidant defenses are extensively distributed and include both enzymatic and non-enzymatic systems. The aim of the present study was to determine lipid peroxidation and total radical-trapping potential (TRAP) changes in lungs of rats submitted to different models of chronic stress. Adult male Wistar rats weighing 180-230 g were submitted to different stressors (variable stress, N = 7) or repeated restraint stress for 15 (N = 10) or 40 days (N = 6) and compared to control groups (N = 10 each). Lipid peroxidation levels were assessed by thiobarbituric acid reactive substances (TBARS), and TRAP was measured by the decrease in luminescence using the 2-2'-azo-bis(2-amidinopropane)-luminol system. Chronic variable stress induced a 51% increase in oxidative stress in lungs (control group: 0.037 ± 0.002; variable stress: 0.056 ± 0.007, P < 0.01). No difference in TBARS was observed after chronic restraint stress, but a significant 57% increase in TRAP was presented by the group repeatedly restrained for 15 days (control group: 2.48 ± 0.42; stressed: 3.65 ± 0.16, P < 0.05). We conclude that different stressors induce different effects on the oxidative status of the organism.

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Lipid peroxidation in rat lung induced by neuroleptanalgesia and its components

Chinev

Bakalova

et al. 1998

European Journal of Anaesthesiology

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Lipid peroxidation in lung of rat stressed by immobilization: Effects of vitamin E supplementation

Cited by 8 publications

References 17 publications

Effect of 5-day vitamin E supplementation on muscle injury after downhill running in rats

Effect of 5-day vitamin E supplementation on muscle injury after downhill running in rats

Lipid peroxidation and total radical-trapping potential of the lungs of rats submitted to chronic and sub-chronic stress

Lipid peroxidation in rat lung induced by neuroleptanalgesia and its components

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